ABSTRACT
Chinese materia medica is mostly taken orally. The permeability of a drug’s biofilm (e.g. cell membrane) reflects its ability of absorption and transportation in the body. It is of guiding significance to evaluate the membrane permeability of the active components of Chinese materia medica by using appropriate drug permeation model, so as to clarify, the oral absorption and transport mechanism of active ingredients, pharmacodynamic substance basis and dosage form design. The evaluation method of oral drug membrane permeability, as well as the application of various methods in Chinese medicine was summarized for reference in this review.
ABSTRACT
Although the basic theory of "Xuanfa Sujiang" has been generally accepted by Chinese medicine practitioners, it is still controversial that traditional Chinese medicine (TCM) theory is combined with modern biology and interpreted by modern science. Based on relevant classical theories, prescriptions, pharmacological substance basis and biological mechanism, we put forward the following points in this paper: The effect and function of "Feiqi" governing organ movement depends on the difference about subtype or expression of adrenergic receptors on the post ganglionic fibers dominated autonomic effector. Coincidentally, TCM theory selected different types of natural effective molecules, such as phenylethylamine and its derivatived alkaloid, to achieve a good sympathetic regulation, and just meet the different needs of clinical treatment; The β-AR/cAMP/PKA signaling pathway is the core pathways for positive regulation; The concept of the "Zhijie" is closely related to the balance of myosin light chain phosphorylation and dephosphorylation levels; Prescription compatibility can effectively enhance the crosstalk between adrenergic receptor-related multiple signal pathways, and reflect the advantages of TCM for complex diseases treatment by multi-ingredients and multi-targets.
ABSTRACT
To review the background and advance of a strategy of bioethnopharmaceutical analytical pharmacology(BAP).BAP is an idea for elucidating absorbed bioactive compound(ABC)in traditional Chinese medicine(TCM)formula or herbal remedy.It is also a mode of active comparison between absorbed compounds and the parent formula including determination of ABC in blood,the ABC dosage identical to its content in formula,and the active comparison of ABC and the parent formula.The ABC of Guan-Xin-Er-Hao formula elucidated by BAP strategy has been reviewed and the significance of BAP strategy will be further discussed.