ABSTRACT
OBJECTIVE:To observe the efficacy and safety of different administration of dexamethasone in the treatment of se-cretory otitis media. METHODS:Data of 92 patients with secretory otitis media was retrospectively collected and divided into ob-servation group(43 cases)and control group(49 cases)by different administration. Observation group received 5 mg Dexametha-sone injection by injection in the eustachian tube in the assisted by video laryngoscope,once every 2 day. Control group received 5 mg Dexamethasone injection by injection in the eustachian tube,once every 2 day. 7-day was regarded as 1 treatment course. 1 more course for uncured patients,and no more than 4 courses. Clinical efficacy,and tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),IL-10 levels before and after treatment,and 1-year cumulative recurrence rate after cured and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was signifi-cantly higher than control group,1-year cumulative recurrence rate after cured was significantly lower than control group,the dif-ferences were statistically significant(P0.05). After treatment,TNF-α and IL-6 level in 2 groups were significantly lower than before, and observation group was lower than control group,the differences were statistically significant(P0.05). And there was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:The efficacy of dexamethasone by injection in the eustachian tube in the assisted by electron-nasopharyngolaryngoscopy is superior to auripuncture administration,it can reduce re-currence rate,with good safety.
ABSTRACT
Objective To study the causes and clinical features associated with hoarseness in children.Meth-ods The data of 4 668 children suffering from hoarseness were analyzed with electronic-nasopharyngolaryngosco-py retrospectively.ResuIts The top 6 common causes of hoarseness were chronic laryngitis (1 817 cases,38.9%), vocal cord nodules (1 494 cases,32.0%),vocal hypertrophy (560 cases,12.0%),the paralysis of vocal cord (373 cases,8.0%),congenital sulcus vocalis (149 cases,3.2%)and recurrent respiratory papilloma disease (140 cases,3. 0%).These six diseases were common in children with hoarseness with 4 533 out of 4668 (97.1%);of the chil-dren were 2 to 10 years old as the largest age group (65.8%,3 072/4 668)and the ratio of male and female was 2. 48:1.The top six diseases were statistically distributed in different age groups (P<0.01).ConcIusion The main causes of hoarseness were different in different age groups.The children aged 2 to 10 years old made up the largest group (3 072/4 668),showing the greatest incidence of hoarseness in children .The incidence for male patients was higher than female and the chronic laryngitis was the top disease.Hoarseness in children was different from that of adults so that to understand the characteristics of this disorder in children will be beneficial to the proper diagnosis and effective treatment.