ABSTRACT
Objective: To better understand the effect of propofol on the spinal cord levels, and investigate whether there are different effects of propofol between nociceptive input and non-nociceptive input. Method: All Sprague-Dawley rats were spinally transected, the effect of propofol (2mg/kg, Ⅳ) on C response to the firing of electromyography, and the discharges of dorsal horn neurons were observed. Result: Propofol can produce a profound inhibition on C response,early discharges,late discharges and spontaneous discharges. Compared with early discharges, the extent of inhibition of late discharges increased but the lasting time was shorten. Conclusion: Propofol can suppress the transmission of nociceptive and non-nociceptive stimulus in spinal cord with stronger inhibition on nociceptive input,and the shorter lasting time. It is indicated that the loss of sense and pain results from the effect of propofol on the spinal cord.