ABSTRACT
In order to determine whether the cAMP is a central madiator and participates in the mechanism of the ET-induced fever, in the following experiments, we have compared the cAMP levels in csf, plasma to the cAMP levels in tissues of hypothalamus, brain-stem and brain-cortex during the ET-induced fever. The results obtained demonstrate: the cAMP Ievels in tissues of hypothalamus and in csf are increased markedly during the fever Compared with the normal control. These changes of the cAMP levels are paralleled and correlated apparently with the body temperature. However, there isn't any obvious change of the cAMP levels in the tissues of brain-stem, brain-cortex and in plasma during the fever. This demonstrats that the cAMP increased in csf may indirectly reflect cAMP level in hypothalamus during the fever in rabbits and the main source of cAMP increased in csf may be synthesized and released by hypothalamus.