Inefficacious drugs against covid-19: analysis of sales, tweets, and search engines / Medicamentos ineficazes contra covid-19: análise de vendas, tweets e mecanismos de busca

ABSTRACT OBJECTIVE Assess the correlation between the sales of two drugs with no proven efficacy against covid-19, ivermectin and chloroquine, and other relevant variables, such as Google® searches, number of tweets related to these drugs, number of cases and deaths resulting from covid-19. METHODS The methodology adopted in this study has four stages: data collection, data processing, exploratory data analysis, and correlation analysis. Spearman's method was used to obtain cross-correlations between each pair of variables. RESULTS The results show similar behaviors between variables. Peaks occurred in the same or near periods. The exploratory data analysis showed shortage of chloroquine in the period corresponding to the beginning of advertising for the application of these drugs against covid-19. Both drugs showed a high and statistically significant correlation with the other variables. Also, some of them showed a higher correlation with drug sales when we employed a one-month lag. In the case of chloroquine, this was observed for the number of deaths. In the case of ivermectin, this was observed for the number of tweets, cases, and deaths. CONCLUSIONS The results contribute to decision making in crisis management by governments, industries, and stores. In times of crisis, as observed during the covid-19 pandemic, some variables can help sales forecasting, especially Google® and tweets, which provide a real-time analysis of the situation. Monitoring social media platforms and search engines would allow the determination of drug use by the population and better prediction of potential peaks in the demand for these drugs.

RESUMO OBJETIVO Investigar a correlação entre as vendas de dois medicamentos sem eficácia comprovada no tratamento de covid-19, ivermectina e cloroquina, e outras variáveis relevantes: pesquisas no Google®, número de tweets relacionados aos medicamentos, casos e óbitos decorrentes da covid-19. MÉTODOS A metodologia adotada neste estudo se divide em quatro partes: coleta de dados; processamento dos dados; análise exploratória; e análise de correlação. Foi utilizado o método de Spearman para obter as correlações cruzadas entre cada par de variáveis. RESULTADOS Os resultados mostram similaridade entre os comportamentos das variáveis. Os picos ocorreram em períodos iguais ou próximos. A análise exploratória dos dados apontou que houve falta de cloroquina no período correspondente ao início das divulgações sobre a aplicação desses medicamentos para o tratamento da covid-19. Ambos os medicamentos apresentaram correlação alta e estatisticamente significativa com as demais variáveis analisadas. Também foi observado que algumas delas apresentaram maior correlação com as vendas de medicamentos quando assumiram defasagem temporal de um mês. No caso da cloroquina, isso ocorreu com a variável óbitos. No caso da ivermectina, ocorreu com as variáveis número de tweets, casos e óbitos. CONCLUSÕES Os resultados observados contribuem para a tomada de decisão durante a gestão de crises por parte de governo, indústrias e comércios. Em momentos de crises, como observado durante a pandemia, as variáveis mostraram que são capazes de auxiliar na previsão de vendas, em especial o Google® e os tweets, que proporcionam uma análise em tempo real da situação. Acompanhar as redes sociais e mecanismos de busca permitiria detecção de uso pela população e melhor previsão de potenciais picos de demanda desses medicamentos.

Perspectives of Teachers at Medical Colleges Across India regarding the Competency based Medical Education Curriculum – A Qualitative, Manual, Theoretical Thematic Content Analysis

Background: Competency-based medical education (CBME) curriculum has been implemented in India since 2019 with a goal to create an “Indian Medical Graduate” (IMG) possessing requisite knowledge, skills, attitudes, values, and responsiveness. Objectives: To explore teachers’ perceptions across India at medical colleges on the newly implemented competency-based medical education curriculum. Methods: This was a qualitative cross?sectional study conducted among teachers working at medical colleges across India, between February and April 2022 (n = 192). The data collection was done using Google forms online survey platform on teachers’ perception regarding CBME, its specific components, and perceived bottlenecks. We analyzed this qualitative data using manual, theoretical thematic content analysis following the steps endorsed in Braun and Clarke’s six-phase framework. Results: The majority of the teachers (64.1%) have positively responded to the CBME curriculum’s implementation. However, it came with a caution that the curriculum should continuously evolve and adapt to regional demands. The foundation course, early clinical exposure, and the family adoption program were the specific components of CBME curriculum over which the teachers raised concerns. The need for additional teachers in each department (department-specific teacher or faculty per hundred students ratio to be worked out) and the need for enabling faculty preparedness through adequate training was highlighted. Concerns were also raised regarding implementing CBME with teachers without a medical background (especially in preclinical departments). Conclusion: It is the need of the hour for the curriculum to incorporate a systematic feedback mechanism built into the system, though which such critical appraisals can be meaning collated and acted upon, to ultimately evolve, thereby creating an “Indian Medical Graduate” for the needs of todays’ society.

Research progress in epigenetic toxicity of diesel exhausts / 环境与职业医学

Diesel exhaust (DE) can enter the organism body and cause multiple organ damage. DE contains particles that can be suspended in the air for a long time. Epigenetic regulation is a post transcriptional regulation change that does not involve DNA sequence changes. Many evidences showed that DE can affect the normal physiological functions of multiple organs and systems through epigenetic changes, thus regulating the occurrence and development of multiple diseases. This paper reviewed the research progress of DNA methylation and non-coding RNA in the biological harmful effects of DE. This will provide a basis for the safety evaluation, health risk assessment, and management of DE.

Análisis de la mezcla de alcoholes en motor diésel

Debido a que el futuro del petróleo es incierto, en la búsqueda de los combustibles alternativos se ha encontrado que el alcohol es un fuerte candidato como combustible; los alcoholes inferiores más representativos son el metanol y el etanol, los cuales han demostrado en general baja miscibilidad, por lo que pueden generar una separación de fases al ser mezclados después de un cierto tiempo. La única manera de emplearlos en un motor diésel es mezclándolos con biodiésel o con surfactantes. Por el contrario, los alcoholes superiores tienen características más adecuadas para ser mezclados o empleados en el motor diésel. Por su parte, los éteres son una buena opción cuando se trate de combustión piloto en que se considere emplear combustibles gaseosos como el biogás o el syngas en motor diésel dual. En esta investigación se exploran las alternativas que existen para mejorar las características del alcohol, por ejemplo, mezclarlo con biodiésel, biogás, agua o nanopartículas, y también se analizan las emisiones que se producen con las mezclas generadas. El objetivo es indagar las diferencias entre los alcoholes inferiores y los alcoholes superiores de cadena larga, así como las mezclas que se pueden generar para mejorar el rendimiento del motor. Los resultados afirman que los alcoholes de cadena larga tienen mejores propiedades físico-químicas que los alcoholes de cadena corta; el butanol es el único combustible que puede ser transportado y almacenado en las mismas redes de tuberías actuales de los productos petroleros existentes. También se cuenta con la opción de usar el alcohol como combustible piloto en un motor diésel dual; esto puede servir para aplicar una enorme variedad de combustibles tanto líquidos como gaseosos, lo cual hace que las opciones en su aplicación se incrementen. Como conclusión, se recomienda explorar nuevas mezclas analizando sus sinergias con varios combustibles alternativos. La posibilidad de realizar el diesterol-BED genera resultados muy alentadores, por lo que se recomienda seguir haciendo análisis sobre esa línea para encontrar la mezcla óptima.

As the future of oil is uncertain and in the search for alternative fuels, it has been found that alcohol is a strong candidate as a fuel. The most representative lower alcohols are methanol and ethanol, which have generally demonstrated low miscibility so that they can generate phase separation when mixed after a certain period of time. The only way to use them in a diesel engine is to mix them with biodiesel or surfactants. By contrast, higher alcohols have more suitable characteristics to be mixed or used in the diesel engine. In the case of ethers they are a good option when it comes to pilot combustion considering using gaseous fuels such as biogas or syngas in dual diesel engine. This research explores the alternatives that exist to improve the characteristics of alcohol as it can be mixed with biodiesel, biogas, water or nanoparticles and also analyzes the emissions that are generated with the mixtures. The aim of this research is to explore the differences between lower alcohols and long chain upper alcohols, as well as the mixtures that can be generated to improve engine performance. The results of this research claim that long-chain alcohols have better physico-chemical properties than short-chain alcohols, butanol being the only fuel that can be transported and stored in the same current pipeline networks of existing oil products. There is also the option to use alcohol as a pilot fuel in a dual diesel engine. The latter can be used to apply a huge variety of both liquid and gaseous fuels, this makes the options in its application increase. As a conclusion of this work, it is recommended to explore new mixtures analyzing their synergies with various alternative fuels. The possibility of performing diesterol-BED generates very encouraging results, therefore it is recommended to continue to perform analyses on that line to find the optimal mixture.

Na busca por combustíveis alternativos porque o futuro do petróleo é incerto, verificou-se que o álcool é um forte candidato como combustível, onde os álcoois inferiores mais representativos são o metanol e o etanol, que, em geral, demonstraram baixa miscibilidade, de modo que podem gerar separação de fase quando misturadas após um determinado período de tempo, a única forma de as utilizar num motor diesel é misturá-las com biodiesel ou tensioactivos, pelo contrário, os álcoois superiores têm características mais adequadas para serem misturados ou utilizados no motor diesel, no caso dos éteres, são uma boa opção quando se trata de combustão piloto, considerando a utilização de combustíveis gasosos, como biogás ou gás de síntese em motores a diesel duplos, esta pesquisa explora as várias alternativas que existem para melhorar as características do álcool, pois pode ser misturado com biodiesel, biogás, água ou nanopartículas e também analisa as emissões que são geradas com as misturas geradas, O objetivo desta pesquisa é explorar as diferenças entre álcoois inferiores e álcoois superiores de cadeia longa, bem como as misturas que podem ser geradas para melhorar o desempenho do motor. Os resultados desta pesquisa afirmam que os álcoois de cadeia longa têm melhores propriedades físico-químicas do que os álcoois de cadeia curta, sendo o butanol o único combustível que pode ser transportado e armazenado nas mesmas redes de gasodutos atuais que os produtos petrolíferos existentes, há também a opção de usar álcool como combustível piloto em um motor diesel duplo, Este último pode ser usado para aplicar uma enorme variedade de combustíveis líquidos e gasosos, o que aumenta as opções em sua aplicação. Como conclusão deste trabalho recomenda-se explorar novas misturas analisando suas sinergias com vários combustíveis alternativos, a possibilidade de realizar diesterol-BED gera resultados muito encorajadores, portanto, recomenda-se continuar a realizar análises nessa linha para encontrar a mistura ideal.

EXHAUST EMISSION ANALYSIS OF CI ENGINE USING VARIOUS BLENDS OF PPO-DIESEL

Plastic pyrolysis oil blended with diesel was tested in a single cylinder diesel engine in an experimental study. Waste plastic is used to make plastic pyrolysis oil. Various blends of PPO-DIESEL are tested for engine exhaust emission at various loads in this study. Nitrogen oxide (NOx), carbon monoxide (CO), carbon dioxide (CO2), and hydro carbon (HC) are all measured in engine exhaust emissions. According to the results, D80PPO20 blend is best compared to other fuels for NOx, CO in all blends has no difference at full load, D60PPO40 blend is best compared to other fuels for CO2, and D80PPO20 blend is best compared to other fuels for HC. PPO-DIESEL blends can be used without modification in CI engines.

Control study of the intelligent calculation method and the traditional calculation method in risk assessments of hospitalization / 中华危重病急救医学

Objective:To explore the accuracy of intelligent calculation (IC) method for risk assessment of hospitalization for patients, aiming to build a more advantageous risk assessment system.Methods:The "Search Engine" program was developed based on hospital information system (HIS) of the Fifth Center Hospital in Tianjin, which automatically captured patient information and generated nutritional risk screening 2002 (NRS 2002) score, Caprini thrombosis risk assessment model and Padua thrombosis risk assessment model for venous thromboembolism (VTE), the CHA 2DS 2-VASc for predicting stroke risk stratification in atrial fibrillation and the HAS-BLED for predicting bleeding risk in anticoagulated patients with atrial fibrillation. A randomized controlled trial was conducted. According to the applicable conditions of each risk assessment, 100 risk scores from "Search Engine" program belonged to each risk assessment were randomly selected, defined as the IC group. Manual scoring with the data of the same case at the same time, defined as the traditional calculation (TC) group, compared the consistency of the scores and the difference in time-consuming between the two groups. Results:The Bland-Altman plots showed that the 95% limits of agreement (95% LoA) of NRS 2002 score, Caprini score, Padua score, CHA 2DS 2-VASc score and HAS-BLED score was -0.46 to 0.41, -0.49 to 0.52, -0.50 to 0.41, -0.67 to 0.60, -0.44 to 0.43, respectively, all P > 0.05. In this study, the Bland-Altman plot showed that 95%, 96%, 97%, 97%, 95% plots fell within the 95% LoA in NRS 2002 score, Caprini score, Padua score, wwCHA 2DS 2-VASc score and HAS-BLED score by the two methods, respectively. The all plots of 95% LoA were within the clinically acceptable range (-0.5 to 0.5 scores). The time-consuming of NRS 2002 score, Caprini score, Padua score, CHA 2DS 2-VASc score and HAS-BLED score in IC group were significantly shorter than those in TC group [0.72 (0.71, 0.73) seconds vs. 361.02 (322.41, 361.02) seconds, 0.72 (0.72, 0.73) seconds vs. 196.68 (179.99, 291.20) seconds, 0.72 (0.72, 0.73) seconds vs. 105.75 (92.32, 114.70) seconds, 0.72 (0.71, 0.72) seconds vs. 72.66 (56.24, 84.20) seconds, 0.72 (0.71, 0.72) seconds vs. 51.30 (38.88, 57.15) seconds, respectively, all P < 0.001]. Conclusion:For the above five risk assessments, the TC method and IC method has good consistency in scores, and the IC method is faster, which has good application prospect for clinical application.

Taxa de publicação de resumos da área de Endodontia apresentados na Sociedade Brasileira de Pesquisa Odontológica entre 2013 e 2016 / Full-length publication rates of endodontic abstracts presented at the Brazilian Society of Oral Research meetings between 2013 and 2016

O conceito de Odontologia baseada em evidências requer a produção e publicação de pesquisas de alta qualidade em periódicos internacionais criteriosos. Objetivo: O presente estudo teve como objetivo avaliar as taxas de publicação de resumos endodônticos apresentados na reunião da SBPqO nos anos de 2013, 2014, 2015 e 2016. Material e Métodos: O fator de impacto e a classificação Qualis dos periódicos, e o tempo decorrido entre o congresso e a publicação completa também foram avaliados. Em seguida, foram classificados em seis categorias: pesquisa básica endodôntica, revisão de temas endodônticos, estudos clínicos, ensaios clínicos randomizados, pesquisa básica tecnológica ou relatos de caso. Uma pesquisa em bancos de dados eletrônicos usando o mecanismo Medline (PubMed) foi realizada de janeiro de 2018 a julho de 2018, para identificar publicações escritas em inglês com texto completo dos resumos endodônticos previamente selecionados. A identificação da publicação em texto completo dos resumos foi inicialmente realizada utilizando o sobre- nome do primeiro autor e as principais palavras-chave do título do resumo. Após a verificação do artigo em texto completo, informações adicionais foram registradas, tais como: tempo decorrido até a publicação; nome, fator de impacto e classificação Qualis da revista; e o tipo de estudo. Resultados: Após a leitura do conteúdo da reunião, 1.238 resumos (10,2%) foram considerados de interesse endodôntico e, em seguida, foi realizada uma busca eletrônica no banco de dados. Conclusão: Um grande número de resumos endodônticos não foi publicado como um manuscrito completo. Estudos clínicos e ensaios clínicos randomizados representaram uma pequena parte das publicações (AU).

Evidence-based dentistry consists in the clinical application of concepts based on researches pub- lished as scientific papers in indexed periodicals. Objective: This study aimed to evaluate the publication rates of endodontic abstracts presented in the meeting of SBPqO in the years of 2013, 2014, 2015 and 2016. Materials and Methods: Endodontic abstracts presented between 2013 and 2016 were included. Then, they were classified into six categories: endodontic basic research, review endodontic topics, clinical studies, randomized clinical trials, technological basic research or case reports. An electronic database search using the Medline (PubMed) engine was performed from January 2018 to July 2018 to identify full-text English-written publications of the endodontic abstracts previously selected. The identification of full-text publication of the abstracts was initially performed using the first authors last name and the main keywords from the title of the abstract. Following full-text article verification, additional information was recorded such as: elapsed time until publication; name, impact factor and Qualis classification of the journal; and type of study. Results: After reading the content of the meeting, 1,238 abstracts (10.2%) were considered to be of endodontic interest, and then an electronic database search was performed. Conclusion: A large number of endodontic abstracts were not published as a full-length manuscript. Clinical studies and randomized clinical trials represented the small part of the publications (AU).

Optimización para los motores de búsqueda (SEO) y la garantía de posicionamiento en los buscadores / Search engine optimization (SEO) and search engine positioning guarantee

RESUMEN Una gran parte de la búsqueda y consumo de información digital hoy depende de los motores de búsqueda. Muchos usuarios lo utilizan como el primer paso o punto de acceso para comenzar su consulta de información. Por ello, la optimización y al mismo tiempo la visibilidad en estos buscadores, pasa a ser asunto de prioridad para elaboradores o productores de recursos de información. La optimización para los motores de búsqueda (SEO, por sus siglas en inglés) se refiere al proceso por el cual una página web obtiene y mantiene posiciones notables en las páginas de resultados naturales de los buscadores, también llamados resultados orgánicos o algorítmicos. Este trabajo aborda la importancia que esto reviste para lograr una mejor visualización de la información que se genera en las revistas médicas y en el mundo de la documentación en general.

ABSTRACT A great part of the search and consumption of digital information today depends on search engines. Many users use it as the first step or access point to begin their information inquiry. For this reason, optimization and, at the same time, visibility in these search engines, becomes a matter of priority for developers or producers of information resources. Search engine optimization (SEO) refers to the process by which a web page obtains and maintains notable positions on the pages of natural search engine results, also called organic or algorithmic results. This work comprises the importance of this to achieve a better visualization of the information generated in medical journals and in the documentation world in general.

Google Trends correlation and sensitivity for outbreaks of dengue and yellow fever in the state of São Paulo / Correlação e sensibilidade do Google Trends para surtos de dengue e febre amarela no estado de São Paulo

ABSTRACT Objective To assess Google Trends accuracy for epidemiological surveillance of dengue and yellow fever, and to compare the incidence of these diseases with the popularity of its terms in the state of São Paulo. Methods Retrospective cohort. Google Trends survey results were compared to the actual incidence of diseases, obtained from Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac", in São Paulo, Brazil, in periods between 2017 and 2019. The correlation was calculated by Pearson's coefficient and cross-correlation function. The accuracy was analyzed by sensitivity and specificity values. Results There was a statistically significant correlation between the variables studied for both diseases, Pearson coefficient of 0.91 for dengue and 0.86 for yellow fever. Correlation with up to 4 weeks of anticipation for time series was identified. Sensitivity was 87% and 90%, and specificity 69% and 78% for dengue and yellow fever, respectively. Conclusion The incidence of dengue and yellow fever in the State of São Paulo showed a strong correlation with the popularity of its terms measured by Google Trends in weekly periods. Google Trends tool provided early warning, with high sensitivity, for the detection of outbreaks of these diseases.

RESUMO Objetivo Avaliar a acurácia do Google Trends para vigilância epidemiológica de dengue e febre amarela e comparar a incidência dessas doenças com a popularidade de seus termos no estado de São Paulo. Métodos Coorte retrospectiva. Os resultados da pesquisa Google Trends foram comparados com a incidência real de doenças, obtida do Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac", do estado de São Paulo, nos períodos entre 2017 e 2019. A correlação foi calculada pelo coeficiente de Pearson e pela função de correlação cruzada. A acurácia foi analisada por valores de sensibilidade e especificidade. Resultados Houve correlação estatisticamente significante entre as variáveis estudadas para ambas as doenças, com coeficiente de Pearson de 0,91 para dengue e 0,86 para febre amarela. Foi identificada correlação com até 4 semanas de antecipação para séries temporais. A sensibilidade foi de 87% e 90% e a especificidade de 69% e 78% para dengue e febre amarela, respectivamente. Conclusão A incidência de dengue e febre amarela no estado de São Paulo apresentou forte correlação com a popularidade de seus termos medidos pelo Google Trends em períodos semanais. A ferramenta Google Trends forneceu alerta precoce, com alta sensibilidade, para a detecção de surtos dessas doenças.

Analysis of the diagnosis maneuver of lateral semicircular canal benign positional paroxysmal vertigo and observation of the otolith movement using physical engine / 解剖学报

Objective To analysis the diagnosis maneuvers of lateral semicircular canal benign positional paroxysmal vertigo (BPPV) and to explore the diagnostic mechanism. Methods The three-dimensional BPPV labyrinth model was established based on the physical engine. The otolith in different positions of the lateral semicircular canal was set up. The otolith movement in different positions during the horizontal roll test was analyzed, and the induced nystagmus could be inferred. Results Horizontal roll test nystagmus manifestations were diverse, including bilateral ageotropic nystagmus, which could be judged as otolith in ampullary and crista, and weak side of nystagmus was the affected side; bilateral geotropic nystagmus could be judged as otolith in the long arm of the lateral semicircular canal, and strong side of nystagmuss was the affected side; Ageotropic nystagmus in one side and geotropic nystagmus in another side, considering otolith in ampullary of long arm. The horizontal roll test may restore otolith to utricle and reduce the sensitivity of the diagnostic tests. The result of 10 repetitions were consistent. Conclusion Sixty degree horizontal roll test effectively corrects the defects of 90 degree horizontal roll test. The analysis of diagnostic tests based on the physical engine is of great significance for us to understand the diagnostic mechanism of BPPV in the lateral semicircular canal and to improve and innovate diagnostic maneuver.

Evaluation of glide path preparation and shaping ability of two nickel-titanium engine driven systems in moderate curved root canals / 上海交通大学学报（医学版）

Objective:To evaluate the clinical application effect of two nickel-titanium engine driven systems on moderate curved root canals. Methods:Ninety mesial root canals with moderate curvature of extracted human first mandibular permanent molar were randomly divided into three groups: M3 PRO Group, MTwo group and K group. The glide path was firstly prepared by using #10/04 file in M3 PRO group and MTwo group and #10 file in K group respectively.Then the preparation of root canals up to #25 was performed according to the instruction manual in each different group using standardized technique. All data including time required in glide path preparation, shaping preparation, total root canals preparation and changes of working length in root canal were recorded and analyzed statistically by using Analysis of Variance (ANOVA) and LSD-t tests (P<0.05). Results:Root canal glide path preparation time: MTwo group showed significantly less preparation time while M3 PRO group exhibited significantly the longest preparation time. There was significant difference between MTwo group and M3 PRO group (P=0.001). Root canal shaping preparation time: M3 PRO group showed significantly less preparation time while K group exhibited significantly the longest preparation time. Both MTwo group and M3 PRO group showed significantly less preparation time than K group (P=0.004, P=0.001), but there was no significant difference between MTwo group and M3 PRO group (P=0.573). Total root canal preparation time: MTwo group showed the shortest time while K group exhibited the longest time. There were significant differences between MTwo group, M3 PRO group and K group (P=0.004, P=0.033), but no significant difference between MTwo group and M3 PRO group (P=0.451). Changes of root canal working length: There were significant differences among the three groups (P=0.037, P=0.037, P=0.000). M3 PRO group showed a minimal change while K group exhibited significant changes. Conclusion:MTwo nickel-titanium engine driven system with #10/04 file preform a high efficiency in glide path preparation, whilst M3 PRO nickel-titanium engine driven system show less changes in working length. Under the circumstances where the total time required for root canal preparation is not significant, M3 PRO nickel-titanium engine driven system is more suitable for root canal preparation in moderate curved root canals.

Research on the Construction of TCM Health Intervention Knowledge Base of Female / 世界科学技术-中医药现代化

Objective: To fulfill the TCM (traditional Chinese medicine) health management needs of female through constructing the intervention knowledge base, explore the long-term development mechanism of intervention knowledge base. Methods: The structure of female TCM Health Intervention Knowledge was designed base according to the characteristics of TCM health status of females. The inferential mechanism by studying the relation between the female health status and the diet therapy scheme was explored based on syndrome differentiation. A Long-term development mechanism of TCM health intervention knowledge database was designed based on big data and effect feedback mechanism. Results: The classification standard of the TCM Health Intervention Knowledge base of female includes the state of the viscera functions, qi and blood, yin and yang, and pathogenic properties of the body under the illness and health condition. The dietary therapy formula inference engine can provide food material according to the region, natures, function of tonifying, evil eliminating, to match the female health status, and constantly adjusting and improving the Intervention plan according to the feedback. Conclusion: The study proves the construction plan of TCM Health Intervention Knowledge base of female is able to meet the needs of female TCM health management intervention, and the method of constantly adjusting and improving the intervention plan according to the feedback helps to realize the precise recommendation and long-term development of intervention knowledge base.

Change of occupational stress from 1996 to 2012 among train engine drivers / 中华预防医学杂志

Objective@#To analyze the change of level of occupational stress between 1996 and 2012 among train engine drivers.@*Methods@#the cross-section investigation was conducted by using cluster sampling method, subjects included 1 116 and 1 002 passenger train engine drivers and freight train engine drivers respectively in 1996 and in 2012;occupational stressors, strains, personalities, buffering factors and individual factors were investigated by using Occupational Stress Instruments. Unconditional logistic regression analyses were performed to estimate the associations between job stressors, personalities, buffering factors and individual factors and strains. Multivariate OR(95%CI) were derived from the logistic regression models.@*Results@#From 1996 to 2012, for the passenger train engine drivers the scores of role ambiguity (17.67±5.30 vs.14.11±4.66) increased 25.32%, mental load (10.41±3.56 vs. 16.29±2.08) and physical environment (3.61±2.18 vs. 7.03±1.65) scores decreased 36.10% and 48.64% respectively, sleep disorders (18.04±9.20 vs. 13.35±4.00) and negative affectivity (2.76±1.86 vs. 2.14±1.86) scores increased 33.14% and 28.97% respectively, the differences were statistical significant (P<0.001) . For the freight train engine drivers the scores of sleep disorders (20.33±8.17 vs. 12.47±4.12) and negative affectivity (2.95±1.70 vs. 1.87±1.81) scores increased 57.75% and 60.03% respectively, positive affectivity (2.17±1.60 vs. 2.91±1.50) score decreased 25.43%, the differences were statistical significant (P<0.001) . In general, scores varies in factors related to occupational stress among freight train engine drivers were larger than those among passenger train engine drivers. The risk factor of job dissatisfaction among passenger train drivers in 1996 was insufficient superior support (OR=3.77, 95%CI: 2.23-6.37) , the risk factors in 2012 were insufficient superior support (OR=3.35, 95%CI:1.56-7.17) , poor physical environment (OR=3.61, 95%CI: 1.91-6.80), and fewer positive affectivity (OR=3.47, 95%CI: 1.75-6.82). The risk factor of job dissatisfaction among freight train drivers in 1996 and in 2012 were insufficient superior support (OR (95%CI) were 3.11 (2.31-4.19), 2.59 (1.84-3.65) , respectively).@*Conclusion@#The level of occupational stress among train engine drivers in 2012 was larger than that in 1996, the level of occupational stress among freight train drivers was larger than passenger train drivers, the interventions aimed at reducing occupational stress in the Chinese train engine drivers should take into account promotion for design of job organization and contents and organization management style.

Association of etheno-DNA adduct and DNA methylation level among workers exposed to diesel engine exhaust / 中华预防医学杂志

Objective@#To investigate the association between etheno-DNA adduct and the promoter of DNA methylation levels of cyclin dependent kinase inhibitor 2A (P16), Ras association domain family 1 (RASSF1A) and O-6-methylguanine-DNA methyltransferase (MGMT) in workers with occupational exposure to diesel engine exhaust (DEE).@*Methods@#We recruited 124 diesel engine testing workers as DEE exposure group and 112 water pump operator in the same area as control group in Henan province in 2012 using cluster sampling. The demographic data were obtained by questionnaire survey; urine after work and venous blood samples were collected from each subject. The urinary etheno-DNA adducts were detected using UPLC-MS/MS, including 1,N6-etheno-2'-deoxyadenosine (εdA) and 3,N4-etheno-2'-deoxycytidine(εdC). The DNA methylation levels of P16, RASSF1A, and MGMT were evaluated using bisulfite-pyrosequencing assay. The percentage of methylation was expressed as the 5-methylcytosine (5mC) over the sum of cytosines (%5mC). Spearman correlation and multiple linear regression were applied to analyze the association between etheno-DNA adducts and DNA methylation of P16, RASSF1A, and MGMT.@*Results@#The median (P25-P75) of urinary εdA level was 230.00 (98.04-470.91) pmol/g creatinine in DEE exposure group, and 102.10 (49.95-194.48) creatinine in control group. The level of εdA was higher in DEE exposure group than control group (P<0.001). DNA methylation levels of P16, RASSF1A and MGMT were 2.04±0.41, 2.19 (1.94-2.51), 2.22 (1.94-2.46)%5mC in exposure group, and 2.19±0.40, 2.41 (2.11-2.67), 2.44 (2.15-2.91)%5mC in control group. DNA methylation levels were lower in exposure group (P values were 0.005, 0.002 and 0.001, respectively). Spearman correlation analysis showed that DNA methylation levels of P16, RASSF1A, and MGMT were negative associated with urinary εdA level (r values were -0.155, -0.137, and -0.198, respectively, P<0.05). No significant correlation was observed between the εdC level and any measured DNA methylation levels (P>0.05) . Multiple linear regression confirmed the negative correlation between εdA and DNA methylation levels of P16, RASSF1A, and MGMT in non-smoking group (β (95%CI) was -0.068 (-0.132--0.003), -0.082 (-0.159--0.004) and -0.048 (-0.090--0.007), P values were 0.039, 0.039 and 0.024, respectively). Moreover, εdC was negative associated with DNA methylation level of MGMT in non-smoking group (β (95%CI) was -0.094 (-0.179--0.008), P=0.032).@*Conclusion@#DEE exposure could induce the increased of εdA and decreased of DNA methylation levels of P16, RASSF1A and MGMT.

Construction of Nutrient Content Retrieval Oriented Search Engine for Chinese Recipes / 医学信息学杂志

The paper takes common food materials that contain 5 nutrients of calcium,phosphorus,potassium,sodium and magnesium in the Chinese Dietary Reference Intakes (2013) as authoritative reference data,combines the data of finished dishes obtained from the Internet,and calculates the data by making use of the search engine,database storage and other computer technologies,in order to obtain the list of finished dishes containing certain nutrients,achieve the calculation from nutrients to finished dishes,and provide solutions to the guidance for targeted nutrient supplement diet of residents.

Architecture Design of Medical Geographic Mapping Engine Based on Integrated Platform + Geographic Information System (GIS) / 医学信息学杂志

The paper introduces the study status of domestic and foreign geographic mapping,analyzes the new demands of medical geographic mapping system,studies the medical geographic mapping engine with the function of converting medical data to medical geographic data,and specifically designs the system architecture of the engine,including working mechanism,structure and content,and interlayer function call strategies,etc.

Review on the Construction Methods of Ontology-based Medical Knowledge Base / 医学信息学杂志

Around the ontology construction,diagnosis rule construction,ontology inference mechanism and so on in the process of ontology-based construction of medical knowledge base,the paper states respectively the involved key technologies and methods in each link,lists the examples of the construction of the domain knowledge base through relevant technologies,explores the best method of constructing the medical domain knowledge base.

Methods Using Social Media and Search Queries to Predict Infectious Disease Outbreaks / 대한의료정보학회지

OBJECTIVES: For earlier detection of infectious disease outbreaks, a digital syndromic surveillance system based on search queries or social media should be utilized. By using real-time data sources, a digital syndromic surveillance system can overcome the limitation of time-delay in traditional surveillance systems. Here, we introduce an approach to develop such a digital surveillance system. METHODS: We first explain how the statistics data of infectious diseases, such as influenza and Middle East Respiratory Syndrome (MERS) in Korea, can be collected for reference data. Then we also explain how search engine queries can be retrieved from Google Trends. Finally, we describe the implementation of the prediction model using lagged correlation, which can be calculated by the statistical packages, i.e., SPSS (Statistical Package for the Social Sciences). RESULTS: Lag correlation analyses demonstrated that search engine data/Twitter have a significant temporal relationship with influenza and MERS data. Therefore, the proposed digital surveillance system can be used to predict infectious disease outbreaks earlier. CONCLUSIONS: This prediction method could be the core engine for implementing a (near-) real-time digital surveillance system. A digital surveillance system that uses Internet resources has enormous potential to monitor disease outbreaks in the early phase.

Research and design of mobile medical service platform based on cloud computing / 中国医学装备

Objective:To design a mobile health service platform based on cloud computing so as to reform the current medical problems including serious waste of medical resources, low level of information sharing and poor feel of medical treatment and so on.Methods: On the basic of analyzing cloud computing and relative theories, a solution of mobile medical cloud based on Google App Engine(GAE) was proposed.Results: A mobile medical health service platform including overall business process and deployment of development environment based on GAE has been designed and the traditional medical service mode has been converted.Conclusion: The exploration and attempt that constructe mobile medical health service platform by combining cloud computing with medical services can promote the conversion of medical mode and provide a effective solution for meeting the requirements of medical service quality and service efficiency for the masses.

A comparative study on the user satisfaction between two different piezoelectric engines

PURPOSE: The aim of this study is to compare the performance of two piezoelectric engine systems by surveying satisfaction from dental clinicians. MATERIALS AND METHODS: Two piezoelectric systems were evaluated: TRAUS XUS10 (Saeshin), PIEZOSURGERY touch (Mectron). For this study, 20 dentists responded to the 11 questionnaires in which 5 point Likert-type scale was used. The two devices were operated for 10 seconds and measured 5 times to compare the maximum noise values. In heat emission test, the handpiece was operated for 3 minutes and heat was measured at three positions each. RESULTS: TRAUS XUS10 had higher satisfaction level on motor noise (P < 0.05). About function key and handpiece heat generation, PIEZOSURGERY touch showed higher satisfaction (P < 0.05) than TRAUS XUS10. The maximum noise level for each of the devices was confirmed to be 56.6 dB for the TRAUS XUS10 and 56.0 dB for PIEZOSURGERY touch. The two piezoelectric engines satisfied the safety standards with an operation temperature below 41℃ after having been operated for 3 minutes. CONCLUSION: Except for the function key and handpiece heat emission, TRAUS XUS10 has comparable performance with PIEZOSURGERY touch.