ABSTRACT
Eosinophilic pustular folliculitis (EPF) is an inflammatory disease characterized by pruritic follicular papulopustules of unknown etiology. EPF is clinically characterized by annular configurations on the face, trunk, and extremities. EPF rarely affects the palms and soles where hair follicles are absent. Histopathologically, a number of eosinophils infiltrate around and into hair follicles. A 44-year-old man visited us with pruritic plaques on the face, crusted patches and pustules on the both palms and soles. Histopathologic findings of the pustule on the palms and soles showed spongiosis and intraepidermal vesicular formations containing numerous eosinophils, with dermal perivascular infiltrates consisting of eosinophils and lymphocytes. Histopathologic findings of facial lesion showed dense eosinophils and lymphocytes around hair follicles. Another patient who 28-year-old man visited us with pruritic papules and pustules on the face, trunk, and soles. Histopathologic findings of the pustules on the sole and face were similar with those of the preceding patient. The diagnosis of EPF with palmoplantar involvement was made. The patients were treated with oral dapsone, resulting in a significant improvement in skin lesions. Herein we report two cases of EPF manifested on the face and palmoplantar areas.
Subject(s)
Adult , Humans , Dapsone , Diagnosis , Eosinophils , Extremities , Folliculitis , Hair Follicle , Lymphocytes , SkinABSTRACT
No abstract available.
Subject(s)
Eosinophilia , Eosinophils , Folliculitis , Skin Diseases, Vesiculobullous , TacrolimusABSTRACT
BACKGROUND: Eosinophilic pustular folliculitis (EPF) is characterized by erythematous patches of follicular papules and pustules that mainly involve the face. Although various treatments have been attempted for EPF, including systemic and topical steroids, dapsone and indomethacin, there is no consensus on the first choice for treatment. OBJECTIVE: The purpose of this study was to evaluate the clinical efficacy and safety of naproxen treatment for EPF patients. METHODS: We retrospectively reviewed the clinical records of 16 biopsy-proven EPF patients who were treated with naproxen. Initial dose of oral naproxen was 500 mg to 1,000 mg. Therapeutic effects were evaluated by 3 grades: NR (no response), PR (partial remission, >50% improvement), CR (complete remission). RESULTS: Of the 16 EPF patients, 11 patients (69%) showed either complete remission (50%) or partial remission (19%). The median time to response for good responders (CR+PR) was 1.5 weeks. Two patients (13%) had mild gastrointestinal side effects, such as indigestion, but the symptoms disappeared soon after use of a gastrointestinal protectant. CONCLUSION: Oral naproxen may be an effective and safe treatment modality for EPF.
Subject(s)
Humans , Consensus , Dapsone , Dyspepsia , Eosinophilia , Eosinophils , Folliculitis , Indomethacin , Naproxen , Retrospective Studies , Skin Diseases, Vesiculobullous , SteroidsABSTRACT
Eosinophilic pustular folliculitis (EPF) is characterized by recurrent crops of pruritic, erythematous plaques studded with follicular papules and pustules that often form annular configurations. The distribution is usually asymmetric. A 27-year-old Korean man had atypical clinical findings with a butterfly rash-like symmetric erythema on the face without any papules or pustules and brownish patches with follicular papules on the back, which was diagnosed as EPF by histopathologic findings.
Subject(s)
Adult , Humans , Butterflies , Eosinophils , Erythema , Exanthema , FolliculitisABSTRACT
Recently, a new classification of eosinophilic folliculitis (EF) was made as follows: classic eosinophilic pustular folliculitis (EPF; Ofuji's disease), HIV associated EF, pediatric EF, fungal EF and miscellaneous group. A 10-year-old boy presented with a 2-week history of pruritic, erythematous papules with a plaque on his left cheek. A biopsy specimen revealed folliculitis with predominant eosinophilic infiltrates. Clinicohistopathologically, the most compatible diagnosis was eosinophilic pustular folliculitis and subsequently, dapsone was administered for 2 weeks but the lesion showed insufficient improvement, and the original confluent papules changed to a KOH-positive, arciform scaly lesion. A serial section from the paraffin block of the first biopsy, which had been histopathologically negative for fungal hyphae in the first, revealed hyphae in a single follicular canal in only one section out of 100 sections examined. This is believed to be the first reported case of fungal eosinophilic folliculitis in Korea.
Subject(s)
Child , Humans , Male , Biopsy , Cheek , Classification , Dapsone , Diagnosis , Eosinophils , Folliculitis , HIV , Hyphae , Korea , ParaffinABSTRACT
Eosinophilic pustular folliculitis (EPF) is a rare dermatosis of unknown cause. It is characterized by recurrent crops of sterile, pruritic, follicular papulopustules on the face, trunk, and extremities. Although various treatments have been attempted for EPF, including systemic corticosteroid dapsone, cetrizine, UVB phototherapy, as well as cyclosporin, no uniformly effective treatment has been found. We describe a 20-year-old man with long standing EPF which was resistant to various treatments, but who responded dramatically to indomethacin.
Subject(s)
Humans , Young Adult , Cyclosporine , Dapsone , Eosinophils , Extremities , Folliculitis , Indomethacin , Phototherapy , Skin DiseasesABSTRACT
Eosinophilic pustular folliculitis is a rare skin disease and characterized with recurrent sterile pustules, peripheral eosinophilia. The pathogenesis of this disease is not clear yet, but immunologic factors are assumed to be important. The treatment of this skin disorder includes systemic glucocorticoids, dapsone, NSAIDs etc. We herein report a case of eosinophilic pustular folliculitis treated with dapsone for promoting futher research of this rare disease.
ABSTRACT
Eosinophilic pustular folliculitis(EPF) may be classified into 3 clinical types; classic(Ofuji's disease), HIV-associated, and infantile form. Compared with classical type, HIV-associated eosinophilic folliculitis(HIV-associated EF) reveals the distinctive features, such as scattered erythematous urticarial papules on the trunk, head, neck, and proximal aspect of the extremities. We herein report a case of HIV-associated EF occuring in a 48-year-old man who had severe pruritic, multiple, erythematous, follicular and non follicular papules and nodules on the scalp, face, neck, and anterior chest. Biopsy specimen revealed folliculitis with a predominant eosinophilic infiltrate. To our knowledge, this is the second case of HIV-associated EF in Korea.
Subject(s)
Humans , Middle Aged , Biopsy , Eosinophils , Extremities , Folliculitis , Head , Korea , Neck , Scalp , ThoraxABSTRACT
Eosinophilic pustular folliculitis(EPF) is characterized by recurrent crops of pruritic follicular papules and pustules that occur mainly on the face, trunk, and extremities of young men. EPF in infancy is a rare disorder which reveals the distinctive clinical features consisting of self-limited recurrent papules, pustules, and vesicles appearing in corps, involving mainly or exclusively the scalp. We describe two patients with EPF in infancy. Both patients had self-limited recurrent crops of papules and pustules affecting the scalp only.
Subject(s)
Humans , Male , Eosinophils , Extremities , Folliculitis , ScalpABSTRACT
We report a case of eosinophilic pustular folliculitis in a 6-month-old male infant who had pruritic, tiny, erythematous papulopustules on his scalp and eosinophilia in the peripheral blood. Histopathologic examination revealed an acute follicu1ar and perifollicular inflammatory infiltrate with abundant eosinophils. The patient responded to systemic and topical corticosteroid and dapsone.
Subject(s)
Humans , Infant , Male , Dapsone , Eosinophilia , Eosinophils , Folliculitis , ScalpABSTRACT
Eosinophilic pustular folliculitis(EPF) is characterized by recurrent crops of pruritic follicular papules and pustules that occur mainly on the face, trunk, and extremities. Histologically, the major distinguishing feature is abundant eosinophils that invade sebaceous glands and outer root sheaths of hair follicles. We herein report a typical case of eosinophilic pustular folliculitis for promoting research of this rare disease.
Subject(s)
Eosinophils , Extremities , Folliculitis , Hair Follicle , Rare Diseases , Sebaceous GlandsABSTRACT
Eosinophilic pustular folliculitis(EPF) is characterized by recurrent crops of pruritic follicular papules and pustules that occur mainly on the face. The histological feature is the infiltration of eosinophils into the follicular epidermis and adjacent dermis. Extrafollicular lesions with involvement of palms and soles are not uncommon. Herein, we report a case of EPF with palmoplantar lesions in a 40 year-old woman. Palmoplantar lesions started 2 years ago and the initial clinical impression was palmoplantar pustulosis. For 6 months prior to visit, she had suffered from recurrent skin lesions on the face. A skin biosy taken from the lesion on the face revealed a dense infiltration of eosinophils into the follicles and a skin biopsy obtained from the lesion on palm demonstrated an intraepidermal vesicles filled with red blood cells and eosinophils.
Subject(s)
Adult , Female , Humans , Biopsy , Dermis , Eosinophils , Epidermis , Erythrocytes , Folliculitis , SkinABSTRACT
BACKGROUND: Eosinophilic pustular folliculitis (EPF) is a rare chronic disease of unknown cause with pruritic papulopustular lesions and a prominent eosinophilic infiltrate. OBJECTIVE: The purpose of this study was aimed at evaluating the clinical and histopathological features of EPF. METHODS: The hospital charts and histopathologic slides of 8 patients with EPF diagnosed at Asan Medical Center from 1989 to 1998 were reviewed. We also reviewed the previously published reports of 10 patients with EPF in Korea. RESULTS: Nine male and nine female patients were enrolled in this study. The mean age at diagnosis of EPF was 26 years in men and 27 years in women. All the patients complained of mild to severe pruritus. EPF was presented with follicular papules or pustules, except 2 patients, who presented with erythematous plaques free of papules or pustules. All the patients showed the typical histopathological findings of EPF. Laboratory investigation showed hypereosinophilia in 73% of patients (11/15). The levels of blood eosinophils tended to decrease as cutaneous lesions resolved. EPF was improved with dapsone in 12 patients and the rest were treated with topical or systemic steroid or antihistamines. CONCLUSION: EPF may be more common in Korea than can be suspected. Because EPF showed characteristic histopathological findings and EPF responds well to dapsone, the knowledge with this disease may be important to diagnose and treat it.
Subject(s)
Female , Humans , Male , Chronic Disease , Dapsone , Diagnosis , Eosinophils , Folliculitis , Histamine Antagonists , Korea , PruritusABSTRACT
Eosinophilic pustular folliculitis(EPF) is a rare inflammatory follicular disorder of unknown etiology. EPF is characterized by recurrent clusters of pruritic, follicular, sterile papules and pustules on the seborrheic area of young men. Compared with classical adult type, infantile EPF reveals the distinctive clinical features, such as constant involvement of the scalp, self-healing recurrent crops, and the possibility of lasting until 3 years of age. We describe two patients with infantile EPF. Both patients commonly had recurrent crops of papules and pustules affecting the scalp only. Bacterial and fungal cultures were negative, and one patient showed an eosinophilia. Biopsy specimens revealed folliculitis with a predominant eosinophilic infiltrate. Clinical response to oral antihistamines and topical corticosteroids was noted, but the lesions have been recurrent during the long-term follow-up period of 1 year.
Subject(s)
Adult , Humans , Male , Adrenal Cortex Hormones , Biopsy , Eosinophilia , Eosinophils , Folliculitis , Follow-Up Studies , Histamine Antagonists , ScalpABSTRACT
Eosinophilic pustular folliculitis (EPF) or Ofuji's disease is a cutaneous inflammatory follicular disorder of unknown etiology. It usually affects adults and is clinically characterized by recurrent crops of sterile and pruritic papulopustules grouped in an annular or polycyclic pattern involving preferably the seborrheic areas. Histopathologic examination reveals eosinophilic follicular abscesses. We report a case of eosinophilic pustular folliculitis in a 21-year-old man who showed pruritic erythematous plaques with follicular papules and pustules on the face, back, upper arms, and thigh. Laboratory test showed blood eosinophilia and histopathologic study revealed numerous eosinophilic infiltration in and around the hair follicle. The patient relatively responded well to dapsone and topical steroid.
Subject(s)
Adult , Humans , Young Adult , Abscess , Arm , Dapsone , Eosinophilia , Eosinophils , Folliculitis , Hair Follicle , ThighABSTRACT
We report a case of follicular mucinosis which oecurred in a 28-year old female. She had an adult fist-sized erythemlatous indurated infiltrative plaque with an ill-defined border on the left cheek area. Histopatholcigical findings, including mucin stains, showed characteristic reticular degeneration and cystic spece formation in hair follicles and sebaceous glands with mucinous degeneration and infiltration of abundant eosinophiles. The present case should be differentiated from plaque type eosinophilic pustular folliculitis clinically and histologically.
Subject(s)
Adult , Female , Humans , Cheek , Coloring Agents , Eosinophils , Folliculitis , Hair Follicle , Mucinosis, Follicular , Mucins , Sebaceous GlandsABSTRACT
We report a case of eosinophilic pustular folliculitis in a 42-year-old woman who had atypical clinical findings with moderately pruritic erythematous follicular papules and pustules on the face and neck. Histopathologically miny eosinophils and neutrophils infiltrated around the follicles, within the follicles and around tbe vessels. The follicular walls showed spongiosis. The differential count of eosinophils in seram was 1.9%. The patient responded well to systemic steroid and dapsone.
Subject(s)
Adult , Female , Humans , Dapsone , Eosinophils , Folliculitis , Neck , NeutrophilsABSTRACT
We present three cases of eosinophilic pustular folliculitis without eosinophilia in a 19-year-old female, a 27-year-old male, and a 51-year-old male. Multiple erythematous plaques with papules and pustules were observed on the face in two patients and on the face, trunk, and extremities in the third patient. Histopathologic findings showed hair follicles and the sebaceous glands infiltrated with mixed inflammatory cells composed of eosinophils and neutrophils, characteristic of eosinophilic pustular follicultitis. However, peripheral blood eosinophilia was not present in any of our three cases.