A case report of Olanzapine induced DRESS Syndrome

DRESS syndrome (Drug reaction with eosinophilia and systemic symptoms) is defined as a drug-induced complex of symptoms consisting of fever, rash, lymphadenopathy, eosinophilia and a wide range of mild to severe systemic presentations. Here we report a case of a 24-year-old female who developed a severe generalized Anasarca, skin erythema, facial puffiness, reddish discoloration over the body, fever, eosinophilia, leukocytosis and hepatitis 30 days after ingestion of olanzapine. Considering the occurrence of fever, eosinophilia, enlarged lymph nodes, typical skin rash and internal organ involvement, a ‘’ Probable diagnosis “of DRESS syndrome was made using the RegiSCAR Criteria. DRESS induced by psychotropic medications have been scarcely reported. Extensive reporting and educating clinicians as well as patients regarding DRESS will lead to decreased morbidity as well as mortality. Further research is warranted in elucidating its pathogenesis with the aim of designing personalized treatment plans

Drug‐induced hypersensitivity syndrome / 中国小儿急救医学

Drug‐induced hypersensitivity syndrome is also known as drug reaction with eosinophilia and systemic symptoms which is a rare and serious adverse drug reaction. The clinical manifestations include skin eruption,hematologic abnormalities,lymphadenopathy,and internal organ involvement ( liver,kidney, lung) . Its pathogenesis is still unclear and is considered to be related to a variety of factors,including drug‐specific immune responses,viral reactivation and inheritance. Prompt withdrawal of suspicious drugs is the key to treatment,and the use of systemic corticosteroids and intravenous immunoglobulins remains contro‐versial.

A Case of Allergic Fungal Sinusitis / 대한이비인후과학회지

Allergic fungal sinusitis (AFS) has been clinicopathologically defined as a noninvasive form of fungal infection. AFS was first reported in 1983. The first case of AFS was associated with Aspergillus, but recently other fungal organisms have been implicated. AFS should be suspected in any atopic patients with refractory nasal polyps. Sinus computed tomograms and magnetic resonance imaging findings can be quite distinctive, but definite diagnosis requires histopathologic examination which shows characteristic allergic mucin. Current recommendations for therapy include conservative but complete exenteration of all allergic mucin. Adjunctive systemic steroids are often helpful. The authors present a case of allergic fungal sinusitis for the first time in Korea. The patient had nasal polyp and showed hypersitivity to fungus in RAST, elevation of total IgE, peripheral eosinophilia. On histopathologic examination, typical allergic mucin including Charcot-Leyden crystals, eosinophils and fungal hyphae were found.