ABSTRACT
Objective: To collect the clinical symptoms of novel coronavirus pneumonia, explore and analyze the clauses and prescriptions related to the clinical symptoms of 2019 novel coronavirus pneumonia in “Treatise on differentiation and treatment of epidemic febrile disease”, in order to provide a reference for clinical treatments of the disease. Methods: Searching literature from the databases CNKI and PubMed by entering “novel coronavirus” (in Chinese) and “2019 Novel Coronavirus” as key words, classifying typical symptoms depending on their reported frequencies of occurrence, comparing with related pathogenesis in “Treatise on differentiation and treatment of epidemic febrile disease”, and analyzing clauses and prescriptions combined with the sixth version of “New coronavirus pneumonia diagnosis and treatment scheme”. Results: We optimized 20 literatures published in Chinese or English for the review, in which, a total of 647 clinical cases were reported. Based on that, 28 typical symptoms were summarized, including respiratory symptoms, such as fever and cough; Gastrointestinal symptoms, such as poor appetite, nausea, vomiting, diarrhea; Other symptoms, such as myalgia, fatigue, and so forth. Among them, fever (558 cases), cough (395 cases), and fatigue (257 cases) were the top three clinical symptoms. By analysis, we optimized 15 clauses, 18 prescriptions, and 46 traditional Chinese medicines from “Treatise on differentiation and treatment of epidemic febrile disease”, including two clauses in the upper energizer, nine in the middle energizer, and four in the lower energizer; A total of seven prescriptions for treating dampness-heat, five for cold-dampness, and six for warm-heat diseases; as well as Chinese medicines Pinellia ternata (mentioned for six times), Cinnamomi Ramulus (five times), Tetrapanacis Medulla (five times), Poria cocos (four times), Talcum (four times), Coptis chinensis (four times) and Coicis Semen (four times), etc. P. ternata, Cinnamomi Ramulus, C. chinensis, Scutellaria baicalensis, and Zingiberis Rhizoma were selected to treat dampness-heat diseases, in order to “pungency opening and bitter discharging”; P. cocos, Tetrapanacis Medulla, Talcum, and Coicis Semen were selected for “eliminating dampness with bland medicinal”; Almond, Amomum kravanh, and Magnolia officinalis were used to “regulating qi movement”; Anemarrhenae Rhizoma, Gypsum Fibrosum, and Forsythiae Fructus were used to treat warm-hot diseases for “purging fire and removing toxin”. The formula of Sanren Decoction, Yiyizhuye Powder can be used for people in the stage of medical observation period; Sanren Decoction, Yiyizhuye Powder, Xingrenyiyi Decoction, Wuling Powder, Baihujiaguizhi Decoction, and Lingjiangzhugui Decoction for treating mild cases; Huangqin Huashi Tang, Xingren Huashi Decoction, and Fulingpi Decoction for severe cases; Jiaomei Decoction, Jianweiwumei Pill, Sini Decoction, and Taohua Porridge for critical patients, and Maidong Maren Decoction, Wuzhi Yin, and Niuru Yin for convalescents. Conclusion: The prescriptions of “Treatise on differentiation and treatment of epidemic febrile disease” can provide reference for the clinical treatments of 2019 novel coronavirus pneumonia.
ABSTRACT
OBJECTIVE To discuss about the influence of the monograph Treatise on Pestilence(Wenyilun) dealing with infectious disease on traditional Chinese medicine(TCM).It was the first time alternatively to describe about infectious disease in etiology,pathogenesis and treatment by TCM way. METHODS In etiology,it was described Zaqi(a special pathogenic factor) to cause infectious epidemic disease,not by general six pathogenic factors.It was similar with modern medicine in etiology.In pathology,it was analyzed and differentiated the developing of an epidemic febrile disease treatment with Qi and Xue.In treatment,it used elimination treatment method including diaphoresis,inducing emesis,and purgation therapy. RESULTS Since then a new science of epidemic febrile disease of TCM was gradually formed. CONCLUSIONS This new theory has deeply influenced in the analysis and differentiation and treatment of epidemic febrile disease.Now theory on epidemis febrile disease of TCM is becoming a systemic and comprehensive doctrine about infectious disease treatment in modern Chinese medicine.
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Objective To observe the change regularity of IL-1?, IL-6, IL-10 and explore the mechanism of Yingfen syndrome (YS) in epidemic febrile diseases. Methods One hundred and four cases were divided into acute leukemia (AL) group and non-acute leukemia (NAL) group according to different diseases. According to syndrome differentiation of TCM, AL group was classified to 10 cases for Weifen syndrome (WS), 12 cases for Qifen syndrome (QS), and 20 cases for YS. NAL group was classified to 20 cases for WS, 24 cases for QS and 18 cases for YS. Fifteen healthy persons were selected for comparison. The levels of IL-1?, IL-6 and IL-10 in YS, WS and QS of various diseases were observed. Results In YS period, IL-1? and IL-6 increased continuously, while IL-10 decreased markedly, compared with healthy people (P 0.05), while on difference in IL-6, IL-10 between different diseases (P