ABSTRACT
Odontogenic tumours encompass a diverse group of uncommon tumours that are frequently aggressive in their biological behaviour. They comprise 2.4% of all the lesions biopsied in the dental office. Odontogenic tumours have for years been recognized for presenting clinical & histopathological challenges arising from epithelial, ectomesenchymal and/or mesenchymal elements of tooth forming tissues. Understanding of the most common and rare odontogenic tumours will be of great use in their study and clinical management. Histological patterns and sub-patterns are characteristic of particular tumours, hence serve as a proverbial beacon to arrive at a confirmatory histopathological diagnosis. The molecular mechanisms of Epithelial Mesenchymal Interaction have long been studied as a basis for these versatile tumour patterns. Morphogenesis and cell differentiation in the developing tooth are controlled by a series of reciprocal interactions between the epithelial and mesenchymal tissues. In these rare neoplasms, there is lack of information about ectomesenchymal interactions which is involved in the pathogenesis of these tumours. Our paper aims to assess the validity of tumour pattern as a unique prognostic parameter for odontogenic tumours.
ABSTRACT
Este artigo apresenta uma revisão bibliográfica sobre a genética da formação dos dentes. São aqui abordadas as principais moléculas envolvidas na interação epitélio-mesênquima, responsável pela formação da estrutura dental. O objetivo é contribuir para um melhor entendimento da cascata genética envolvida na formação do dente, bem como auxiliar na prática odontológica, procurando despertar a atenção do profissional para o conhecimento científico e facilitar assim a identificação de possíveis problemas, como as más oclusões, suas causas e conseqüências.
Through a review of the literature, this article discusses the genetic mechanisms that control tooth morphogenesis. Emphasis is placed upon the structure and function of some key molecules that participate in interactions between its epithelial-mesenchimal components. In this paper we will understand the mechanisms that control tooth morphogenesis and the dentistry should pay special attention to possible consequences of tooth number anomalies.