ABSTRACT
It is possible to define the premenstrual syndrome (PMS) as the cycle occurrence of psychological and somatic symptoms in the luteal phase of the menstrual cycle that disappear at, or soon after, the onset of menstruation. Some skin disease, such as estrogen dermatitis and autoimmune progesterone dermatitis, has been related to a premenstrual flare. The clinical picture is varied with pruritus, either generalized or localized or as urticaria and eczematous skin eruption. The hallmark of estrogen dermatitis is the cyclic premenstrual flare. A 39-year-old female patient presented with a perioidic of skin lesions on both hands and leg. The skin eruption commenced in the second half of the menstrual cycle, worsened through the luteal phase but the lesion almost disappeared during menstruation. An intradermal skin test to estrone showed positive results. However, a skin test with medroxyprogeterone acetate (Depo-Provera(r)) was negative. After systemic steroid and antihistamine therapy, the lesions were found to be significantly improved.
Subject(s)
Adult , Female , Humans , Autoimmune Diseases , Dermatitis , Erythema Multiforme , Estrogens , Estrone , Hand , Leg , Luteal Phase , Menstrual Cycle , Menstruation , Premenstrual Syndrome , Progesterone , Pruritus , Skin , Skin Diseases , Skin Tests , UrticariaABSTRACT
Estrogen dermatitis is a rare cutaneous disorder characterized by recurrent cyclic eruptions during the luteal phase of the menstrual cycle. The clinical manifestations include pruritus, urticaria, vesicles, papules and eczematous eruptions. A 22-year-old female patient presented with a skin lesion on the back of 6 years periodic duration. She had been recurrently suffering from pruritic eruptions that appear during the luteal phase of the menstrual cycle and resolve after menses. An intradermal skin test to estrogen showed a positive result, but showed negative results to progesterone. After antiestrogen tamoxifen therapy, the lesions were found to have significantly improved.