ABSTRACT
Objective To explore the associations between microsatellites in gonadal receptor genes and dysfunctional attitudes in adolescent with major depressive disorder(MDD).Methods Polymerase chain reaction(PCR),capillary electrophoresis and genetic scanning were performed in testing the length of microsatellites in first-onset adolescent depressive patients.Dysfunctional attitudes scale(DAS) was used in rating the dysfunctional cognition of adolescent depressive sample.These results were tested by correlative analysis and comparison analysis.Results 1.There existed significantly negative correlation between microsatellite′s length in estrogen receptor ?(ER?) gene and total score of DAS in female adolescent patients with first-onset depressive disorder.2.DAS′ total score of shorter alleles′ group was significantly higher than that of longer alleles′ group on female′ estrogen receptor ?(ER?) Gene.Conclusion The microsatellite′s length of ER? and ER? gene may have associations with dysfunctional attitudes of female adolescent with MDD.
ABSTRACT
Objective To observe the effect of preventive acupuncture and moxibustion at Guanyuan(CV 4)on abnormal activity in early climacteric rats.Methods Using four-month-old female SD rats as young control group,the 24 ten-month-old SD female rats screened by vaginal smear were randomized into 4 groups.The climacteric models by natural aging were established.The changes of estrogen receptor(ER-?)and heat shock protein-70(HSP-70)expressions resulted from the effect of preventive acupuncture and preventive moxibustion were observed.Results The expression of ER-? decreased gradually in the uterus of natural climacteric rats(P