ABSTRACT
AIM: To analyze and discuss individual combination of femtosecond laser keratectomy excimer laser treatment of myopia clinical effect, thus providing the basis for clinical treatment. ●METHODS:A total of 320 cases (509 eyes) with myopia were divided into the observation group and the control group according to the patient surgery program from Jan. 2010 to Jan. 2015 in the hospital. The observation group were treated with femtosecond laser combined with individual excimer laser keratectomy ( ORK ) treatment. The control group were treated with ORK mechanical knife treatment system valve. ●RESULTS: ln patients with low and moderate myopia, the average visual acuity of observation group and control group were 5.11±0.09 and 5.10±0.08 postoperative 6mo. The average visual acuity of observation group and control group were 5. 09±0. 05 and 5. 08±0. 05 postoperative 6mo in patients with high myopia. After treatment, the visual acuity was improved, and there was no significant difference between the two groups ( P > 0. 05 ). After treatment, the observation group corneal aspherical coefficients Q were significantly lower than the control group (P ● CONCLUSION: Femtosecond laser combined with individual excimer laser keratectomy for myopia has significant clinical effect and good surgical effectiveness. Also, it′s better to maintain the aspheric shape of the cornea improved the visual quality.
ABSTRACT
To evaluate the effect of topical corticosteroid and nonsteroidal antiinflammatory agents on corneal stromal wound healing after excimer laser keratectomy, each eye of 75 rabbit was ablated by excimer laser and the animals were divided into five groups (15 rabbits in each group). That is, group I of 0.1% dexamethasone, group II of 0.1 % fluorometholone, group III of 0.03 % flurbiprofen, group IV of 0.1 % dexamethasone and 0.03 % flurbiprofen and control group of balanced salt solution. All treatment regiments were instilled four times daily after keratectomy. The animals of each group were killed at 1 week, 1month and 3months after surgery to examine the thickness of newly formed collagen, the keratocyte density and the fine structural alteration in keratocytes and stroma. The results were as follows; 1. The thickness of the new stroma was maximum in control group and minimum in group IV, and significantly different not only between the control and each experimental group but also between experimental groups except between group I and IV (p<0.05). 2. The keratocyte count was maximum in control group and minimum in group IV and the difference was significant between the control group and each experimental groups, but among experimental groups there was significant difference between I and III and between III and IV only. 3. Under transmission electron microscope at 12 weeks, the keratocyte activity and microscopic structural change were markedly subsided in each experimental group but sustainod in control. Basod on these observations, the topically applied steroid and nonsteroidal antiinflammatory drug can modulate the stromal wound healing process after excimer laser keratectomy and the effect, which can be evaluated by the quantitative analysis of the morphologic changes, is the most prominent in Dexamethasone treated group.
Subject(s)
Animals , Rabbits , Anti-Inflammatory Agents, Non-Steroidal , Collagen , Dexamethasone , Fluorometholone , Flurbiprofen , Lasers, Excimer , Steroids , Wound HealingABSTRACT
Epidermal growth factor(EGF), which exists as a constant component of human fluid, was known to stimulate the proliferation and migration of corneal epithelial cells. We investigated the effect of EGF on cornea epithelial wound healing after excimer laser keratectomy. The corneal wound healing was evaluated at every 6 hours on 30 rabbit eyes (5 group) exposed to different EGF concentrations during the organ culture. The results obtained are as follows: The area of epithelial defect was significantly smaller in the EGF treated groups as compared with the control group. However, there was no statistical difference in the area of epithelial defect among the different concentrations of the EGF treated group. The rates of the wound healing in the EGF treated groups seem to be faster than the control group, however, it was statistically insignificant. At 6 and 12 hours after the culture, the rates of wound healing of all the EGF treated group were significantly faster than thouse of the control group. Therefore, the exogenous EGF was found to be effective on the experimental cornea epithelial wound healing after excimer laser keratectomy, showing its maximal effect at 12 hours after treatment.