Exophytic and fungating papillary thyroid carcinoma: A rare and complex presentation of a well-differentiated malignancy

@#Papillary thyroid carcinoma is the most common well-differentiated thyroid malignancy accounting for more than 80 to 90% of all thyroid tumors. It has an overall excellent prognosis owing to advances in screening via imaging and ultrasound-guided fine-needle aspiration biopsy, which have facilitated early detection, diagnosis, and surgical treatment followed by adjuvant radioactive iodine therapy. Exceptionally rare cases of papillary thyroid tumors may present with enormous growth due to delayed consultation and, thus, late diagnosis, posing a challenge to definitive management, quality of life, overall survival, and prognosis. We report a case of a 35-year-old woman who presented with a 4-year history of a bleeding exophytic and fungating anterior neck mass. Computed tomography showed a fungating mass arising from the left thyroid lobe that measured 14.1 x 14.0 x 11.1 cm with areas of necrosis and hemorrhage, left internal jugular vein thrombus formation, and compression of the left internal carotid artery. The mass causes a displacement of the trachea to the right side and multiple bilateral cervical lymphadenopathies. The patient was fully aware, and she consented to undergo wide excision, total thyroidectomy, neck dissection, and pectoralis major muscle flap reconstruction. However, she went into arrest intraoperatively attributed to massive pulmonary embolism. Papillary thyroid cancer is well known for its excellent prognosis. However, outcomes may not be favorable and can even be fatal in advanced and extensive cases. Although fungating papillary cancers are rare, they remain more common in the developing countries, where early detection and access to healthcare remains limited. They also represent a big challenge to surgeons. Even if the outcome was not good, we opted to report this case as there were many learning points. If only patients with good and excellent outcomes are reported in the literature, it will overestimate the treatment success of these complex cases.

Surgical management of plexiform ameloblastoma presenting as exophytic growth ­ A rare entity

Ameloblastoma is locally aggressive neoplasm of odontogenic origin comprising about 1% among tumours and cysts that usually occurs in the vicinity of the mandibular molars or ramus of the mandible. Predominantly occurring in third to fifth decade, with no gender propensity. Inadequate treatment may lead to recurrence in certain cases. Even though benign in growth, they are locally aggressive and can occasionally metastasize. Of them, a unique exophytic presentation of plexiform ameloblastoma in a 22-year-old male patient is documented as follows.

Tratamiento quirúrgico del carcinoma epidermoide de un 40 % del labio inferior. Reporte de caso / Surgical treatment of squamous cell carcinoma of 40 % of the lower lip. Case report

RESUMEN Fundamento: La técnica del tonel de Schuchardt, está indicada cuando el defecto en el labio compromete del 30-75 % del labio, de localización central y paramedial que afecta bermellón y piel; en este caso se usó el colgajo para reconstruir una lesión tumoral más lateral. La técnica aparece descrita para extraer el tonel de espesor parcial, sin embargo, teniendo en cuenta el margen oncológico recomendado en este caso la excéresis abarcó todo el espesor del labio. Objetivo: Presentar un caso de un paciente con un carcinoma epidermoide del 40 % en el labio inferior intervenido en el Hospital General Camilo Cienfuegos. Presentación del caso: Paciente masculino de 43 años de edad tratado durante un año por queilitis actínica, portador de una lesión exofítica, infiltrante que ocupaba el 40 % del labio inferior. Se estableció como impresión diagnóstica un carcinoma epidermoide y se decidió el tratamiento quirúrgico. Atendiendo a las características individuales del paciente y a las de la lesión, se eligió la técnica del tonel descrita por Schuchardt. Conclusiones: Las lesiones malignas de los labios pueden incidir enmascaradas por el cuadro clínico de lesiones premalignas como la queilitis actínica por lo que es importante mantener un seguimiento estrecho de estos casos. Al aplicar el método clínico puede decidirse la intervención quirúrgica con diagnóstico presuntivo de carcinoma epidermoide, deben respetarse entonces los márgenes oncológicos recomendados. La técnica del tonel inicialmente descrita para pérdidas de tejidos mediales y paramediales del labio, de espesor parcial puede emplearse en defectos de localización más lateral y de espesor total con resultados satisfactorios.

ABSTRACT Background: The barrel of Schuchardt technique, is indicated when the defect in the lip compromises 30-75 % of it, from central to paramedial location which affects both, vermilion and skin; in this case, the flap was used for rebuilding a more lateral tumor lesion. The technique is described to extract the partial thickness barrel; however, taking into account the oncological margin recommended in this case, the hysteresis covered the entire thickness of the lip. Objective: To present a case of a patient with 40 % squamous cell carcinoma in the lower lip intervened at Camilo Cienfuegos General Hospital. Case report: A 43-year-old male patient treated for a year having actinic cheilitis, with an infiltrated exophytic lesion, occupying 40 % of the lower lip. A squamous cell carcinoma was diagnosed, so surgical treatment. Based on the individual characteristics of the patient and those of the lesion, the barrel technique described by Schuchardt was chosen. Conclusions: Malignant lesions of the lips can affect masked by the clinical picture of premalignant lesions such as actinic cheilitis, so it is important to keep a close follow-up of these cases. When applying the clinical method, the surgical intervention with presumptive diagnosis of squamous cell carcinoma can be decided, then the recommended oncological margins must be respected. The barrel technique initially described for losses of medial and paramedial tissues of the lip, of partial thickness can be used in defects of more lateral location and of total thickness with satisfactory results.

Perioperative nursing of a patient with giant exophytic hepatocellular carcinoma during lactation / 中国实用护理杂志

Objective@#To summarize the clinical nursing practice experience of a patient with huge exophytic hepatocellular carcinoma during lactation period.@*Methods@#In response to this patient′s perinatal tumor, the disease itself, mother-to-child separation, etc. and thus the patient was easily suffered from negative feelings such as anxiety, fear and worry. Given such conditions, the patients′ psychological status should be evaluated in a sound manner, and then make a personalized plan of stage psychological intervention. Meanwhile, preoperative preparation should be made, for example, enriching nutrition given to the patient in order to enhance her surgery tolerability. Postoperative nursing should be based on specific conditions, especially abdominal pressure should be observed in case the occurrence of complications.@*Results@#The patient was cured and discharged after 14 days of targeted treatment and nursing.@*Conclusions@#Given the patient was in lactation period, there′s great difficulty in performing surgery on her. The nurses should give accurate evaluation on the patient in time, and make personalized nursing plan, pay attention to the emotion in order to reduce the occurrence rate of complications and ensure smooth discharge of the patient.

Pyogenic Granuloma Of Upper Lip: A Case Report

Pyogenic granuloma is a common tumor-like growth of the oral cavity that is supposed to be non-neoplastic in nature. It is a reactional response to minor trauma or chronic irritation and due to hormonal changes. Clinically oral pyogenic granuloma is a smooth or lobulated exophytic lesion on a pedunculated or sessile base, which is mostly haemorrhagic. Although pyogenic granuloma is a non-neoplastic growth in the oral cavity, proper diagnosis, prevention, management and treatment is very important. This case report draws attention towards the uncommon location of the pyogenic granuloma on the upper lip. Surgical excision was done because of the cosmetic disfigurement and discomfort to the patient.

Hiperplasia fibrosa inflamatória provocada por uma prótese parcial removível / Inflammatory fibrous hyperplasia caused by removable partial prosthesis ­ a case report

A hiperplasia fibrosa inflamatória (HFI) é um crescimento gengival que tem como principal causa etiológica o uso de próteses inadequadas ou mal adaptadas. A HFI é uma lesão exofítica benigna de tecido epitelial e conjuntivo fibroso. Seu tratamento de eleição é a exérese cirúrgica e a remoção do agente irritante. Este trabalho teve como objetivo relatar um caso clínico de hiperplasia gengival inflamatória diagnosticada em uma paciente, leucoderma e com 38 anos de idade, que procurou atendimento na Clínica de Periodontia do Sindicato dos Dentistas de Mato Grosso do Sul (Sioms). Após a remoção cirúrgica da lesão e análise histopatológica, o estudo concluiu que o tratamento aplicado neste caso é o mais efetivo para esta patologia, contudo, deve haver avaliações periódicas da prótese para evitar recidiva da lesão.

Inflammatory fibrous hyperplasia (HFI) is a gingival overgrowth that has as its main etiological cause the use of inappropriate or poorly fitting dentures. The HFI is a benign exophytic lesion of epithelial and connective fibrous tissues. The treatment of choice of choice is surgical excision and removal of the irritant. This study aimed to report a clinical case of inflammatory gingival hyperplasia diagnosed in a 38 years-old female patient who sought care in Union Periodontics Clinic of Mato Grosso do Sul Dentists (Sioms). After surgical removal of the lesion and histopathologic analysis the treatment applied in this case is the most effective for this condition, however, periodic reviews must be made to avoid recurrent fibrotic lesions.

Pedunculated Hepatocellular Carcinoma: Distinguishing Features from Conventional Hepatocellular Carcinoma

Malignant pedunculated (exophytic) hepatocellular carcinoma (P-HCC) is a rare entity of hepatocellular carcinoma. Due to its unique characteristics, it gives a different spectrum of clinical findings, radiological presentation and different management approach with reported better outcome to the patients. We present a case report of a lady diagnosed with malignant pedunculated hepatocellular carcinoma.

Peripheral Ameloblastoma of Mandible: A Rare Case Report.

Peripheral ameloblastoma (PA) is a rare, benign, extraosseous neoplasm of the odontogenic epithelium. It is an exophytic growth which is localized to the soft tissues overlying the tooth-bearing areas of maxilla and mandible. In most cases, there is no radiological evidence of bone involvement, except for cupping or saucerization of the underlying bone. Histologically, the PA consists of proliferating odontogenic epithelium that exhibits the same histomorphological cell types and patterns as seen in the intraosseous ameloblastoma. The PA is a slow growing and non-invasive, and recurrence is uncommon following excision, in contrast to central ameloblastoma which is locally invasive and can destroy large segments of the jaw. We report here a case of the plexiform type of PA.

Infección por virus del papiloma humano en la cavidad bucal / Infection due to the human papillomavirus in the oral cavity

Se efectuó un estudio descriptivo y transversal de 75 parejas sexualmente activas, tratadas en la consulta estomatológica del Policlínico de Especialidades perteneciente al Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, desde enero del 2010 hasta igual periodo del 2014, con vistas a determinar la presencia del virus del papiloma humano en la cavidad bucal. Se realizó el examen clínico intrabucal, y como procedimiento diagnóstico corroborativo la colposcopia. Se halló que la totalidad de los integrantes de la serie padecían de esta infección, a pesar de encontrarse asintomáticos en una etapa subclínica donde se observaron pequeñas lesiones exofíticas, aumento de la vascularización y del epitelio blanco. Los resultados citológicos e histológicos obtenidos en la citología exfoliativa y la biopsia confirmaron la presencia de este agente viral dentro de la célula.

A descriptive and cross-sectional study of 75 sexually active couples was carried out, treated in the Stomatology Department from Specialties Polyclinic belonging to "Saturnino Lora Torres" Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, from January, 2010 to the same period of 2014, with the aim of determining the presence of the human papillomavirus in the oral cavity. The clinical intraoral exam was carried out, and the colposcopy was used as corroborative diagnostic procedure. It was found that all the members of the series suffered from this infection, in spite of being asymptomatic in a subclinical stage during which small exophytic injures were observed, increase of the vascularization and of white epithelium. The cytological and histological results obtained in the exfoliative cytology and the biopsy confirmed this viral agent's presence inside the cell.

A Case of Primary Mature Teratoma of the Rectum

A mature teratoma is a tumor composed of normal derivatives of all three germ layers, and usually occurs in ovaries, testes, or mediastinum. Mature teratoma of the gastrointestinal tract occurs less frequently, and case reports of primary mature teratoma of the rectum have not been published much. Here, we report a 65-year-old woman patient presented with lower abdominal discomfort. Colonoscopy revealed a pedunculated polypoid tumor arising from the rectum with hairs on its surface, and endoscopic ultrasound revealed an exophytic pattern bulging from the serosa. The tumor was removed surgically and confirmed histologically as a benign, primary mature teratoma of the rectum.

Extra and Intramedullary Anaplastic Ependymoma in Thoracic Spinal Cord

Spinal ependymoma occupies 40-60% of primary spinal cord tumors and has a feature of intramedullary tumor. The tumor most commonly arises from the central canal of the spinal cord, the conus medullaris or the filum terminale and its pathological features are usually benign. Unlike above characteristics, intra and extramedullary ependymomas are reported very rarely and have wide variety of histological features. We present a rare case of spinal anaplastic ependymoma with an accompanied exophytic lesions extramedullary as well. The tumor was poorly delineated between a spinal cord and the extramedullary components in operative view. After we had confirmed the frozen biopsy as anaplastic ependymoma, the remnant mass embedded in the spinal cord was remained because of its unclear resection margin and the risk of neurological deterioration. She underwent radiotherapy with 50.4 Gy, and there were newly developed mass lesions at the lumbosacral region on the MRI, 14 months postoperatively.

Peripheral Giant Cell Granuloma - A Case Report.

Peripheral giant cell granuloma (PGCG) is a non-neoplastic lesion representing a local hyperplastic reaction. It is a tumorlike pathologic condition arising on the buccal or lingual attached gingival or alveolar mucosa and the crest of the edentulous alveolar ridge, of uncertain etiology; it is probably a reactive lesion caused by chronic local irritants or trauma rather than a true neoplasm. PGCG is thought to originate from elements of the periodontal ligament or from the periosteum. Clinically, it appears as a sessile or broadly pedunculated, bluish to purple-red, fleshy or firm swelling with a frequently ulcerated surface. It may be difficult to distinguish PGCG from pyogenic granuloma and peripheral odontogenic tumors. The clinical appearance of all these lesions is similar, the definitive diagnosis with histological examination is mandatory. Treatment of choice is surgical excision with total removal of the base of the lesion This case aims to present a case of PGCG in 11 year old girl in which surgical resection of the lesion was done to restore functions and esthetics.

Central plexiform ameeloblastoma with exophytic growth a rare case report with review of literature.

Ameloblastomas are predominantly benign, intra-osseous odontogenic tumors and mucosal involvement is a rare secondary phenomenon, occurring only after a long period of intra-osseous growth and bone expansion. This article presents a case report of an eleven year old male patient with a large plexiform ameloblastoma which invaded the soft tissues, presented as an exophytic growth in the mandibular anterior region with radiographic feature of a large unilocular radiolucenc y and displaced mandibular left central incisor. The management comprised of surgical removal of ameloblastoma under local anesthesia along with extraction of displaced mandibular left central incisor.

A case of exophytic pedunculated gastrointestinal stromal tumor with cystic changes / 대한내과학회지

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, and cystic changes are commonly observed. However, there have been few reports of cases of exophytic pedunculated GIST with cystic changes. Here, we report a 45-year-old man who presented with a palpable mass in the left upper quadrant of the abdomen. The mucosal folds were endoscopically abnormal, but there was no mucosal lesion. Computed tomography demonstrated a large, low-density cystic lesion surrounding an enhanced nodule in the greater curvature of the gastric body, and there was no tumor infiltration to other organs. The patient underwent hemigastrectomy and the lesion was shown to be an exophytic pedunculated cystic tumor. Histopathological examination showed epithelioid cells with marked hemorrhaging. Immunohistochemical examination indicated that most of the tumor cell cytoplasm was positive for the c-kit protein (CD117) and CD34. The tumor was diagnosed as an exophytic pedunculated GIST of the stomach with cystic changes.

A Case of Recurrent Schneiderian Papilloma of the Lacrimal Sac Invading the Nasal Cavity

A 44-year-old man presented with a history of chronic epiphora, discharge from the right eye, and a palpable mass in the medial canthal area. Irrigation of the lacrimal system revealed bloody discharge. Orbital magnetic resonance imaging (MRI) showed a well-defined heterogeneous enhanced mass filling the lacrimal sac and upper nasolacrimal duct (NLD). A wide excision and surgical biopsy were performed. Histopathology showed the tumor to be an exophytic Schneiderian papilloma with moderate to severe dysplasia. Three months later, the mass was found to be invading the nasal cavity through the NLD. Endoscopic histopathological evaluation confirmed that it was identical to the originally identified papilloma.

The effect of polyphosphate on exophytic bone formation / 대한치주과학회지

PURPOSE: It has been shown that the inorganic polyphosphate is effective for the regeneration of bones through the preliminary animal test of rabbits. The most effective concentration of the polyphosphate, however, is not known yet. Moreover, the effectiveness of carriers inside human body is not confirmed.. MATERIALS AND METHODS: In this study, we examined the effect of the concentration of the inorganic polyphosphate on the process of the bone regeneration using the 6 weeks old rabbits with the weight of 2.0 kg in average. We performed the experiment using TR-ePTFE membrane(membrane) filled with collagen immersed in 4%, 8% of inorganic polyphosphate, respectively, following removal of the proper sized cortical bones from the rabbit calvaria. The experimental results were compared with the one of the following four groups: The negative control group for membrane only, the positive control group for membrane filled with collagen, the first experimental group for membrane filled with collagen immersed in 4% of inorganic polyphosphate, and the second experimental group for membrane filled with collagen immerse in 8% of inorganic polyphosphate. The fragments of the tissue with membrane obtained from each group of the sacrificed rabbits for 8 or 16 weeks sustained after surgery were then prestained by the Hematoxylin-Eosin stain and coated by resin to form non-decalcified specimens for the histologic examination and analysis. New bone formation was assessed by histomorphometric and statistical analysis. RESULTS: 1. All groups have shown better bone regeneration at 16weeks than 8weeks. 2. Negative control group has shown more bone regeneration relative to the other groups at 8 and 16 weeks. 3. All experimental groups have shown better bone regeneration relative to positive control group. 4. At 16 weeks, the first experimental group has shown more bone regeneration compared to the second experimental group. Exophytic bone formation is not good at the first and the second experimental groups compared with negative control group. But, the use of 4% inorganic polyphosphate was more effective to bone formation than the use of 8% inorganic polyphosphate. CONCLUSION: With above results, it is suggested the use of inorganic polyphosphate with vehicle under TR-ePTFE membrane.

The effect of micro-macroporous biphasic calcium phosphate incorporated with polyphosphate on exophytic bone regeneration / 대한치주과학회지

PURPOSE: In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated. MATERIALS AND METHODS: The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II. RESULTS: 1. Negative control group showed the highest new bone formation at 16 weeks. 2. Positive control group showed the smallest new bone formation compared to other groups. 3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group. CONCLUSION: These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue.

The effect of irradiated cancellous human bone on exophytic bone formation in residual ridge of the beagle dog / 대한치주과학회지

The purpose of this study was to evaluate exophytically vertical bone formation in residual ridge of the beagle dog by the concept of guided bone regeneration with a titanium reinforced e-PTFE membrane combined with irradiated cancellous human bone. Twelve male beagle dogs(mean age 1.5 years and mean weight 12kg) were used for this study. The alveolar ridges after extraction of all mandibular premolars were surgically and horizontally removed. At 8 weeks after extractions, full-thickness flap was reflected and cortical bone was removed with round bur and copious irrigation. Rectangular parallelepiped(10mm in length, 5mm in width, and 4mm in height) bended with titanium-reinforced e-PTFE(TR e-PTFE) membrane was placed on the decorticated alveolar ridge, fixed with metal pins and covered with full-thickness flap and assigned as a control group. Test groups were treated with TR e-PTFE membrane filled with irradiated cancellous human bone. Of twelve beagle dogs, four control dogs and four test dogs without membrane exposure to oral cavity were sacrificed at 8 and 16 weeks respectively. The surgical sites were dissected out, fixed in 4% buffered formaldehyde, dyed using a Villanueva staining technique, and processed for embedding in plastic resin. The cutting and grinding methods were routinely processed for histologic and histomophometric analyis of exophytic bone formation as well as statistical analysis. The results of this study were as follows: 1. Exophytic bone formation in the both of experimental groups was increased respectively after surgery from 23.40% at 8 weeks to 46.26% at 16 weeks in the control groups, from 40.23% at 8 weeks to 47.11% at 16 weeks in the test groups(p<0.05). 2. At 8 weeks after surgery, exophytic bone formation was made 40.23% in the test groups and 33.40% in the control groups. Exophytic bone formation was significantly made in the test group more than in the control group. At 16 weeks after surgery, exophytic bone formation was made 44.11% in the test groups and 46.26% in the control groups. Exophytic bone formation was made in the test groups more than in the control groups, but there was no statistically significant differences. 3. The membrane was fixed with metal pins to closely contact it to the bone surface. So, collapse and deviation of the membrane could be prevented and in growth of connective tissue also could be blocked from the periphery of the membrane. On the basis of these findings, we suggest that intraoral experimental model for exophytic bone formation may be effective to evaluate the effect of bone graft material. And it indicates that combined use of membrane and ICB graft material is more effective than use of membrane only for exophytic bone formation.

The effect of early membrane exposure on exophytic bone formation using perforated titanium membrane / 대한치주과학회지

This study was performed to evaluate the effect of membrane exposure on new bone formation when guided bone regeneration with perforated titanium membrane on atrophic alveolar ridge. The present study attempted to establish a GBR model for four adult beagle dog premolar. Intra-marrow penetration defects were created on the alveolar ridge(twelve weeks after extraction) on the mandibular premolar teeth in the beagle dogs. Space providing perforated titanium membrane with various graft material were implanted to provide for GBR. The graft material were demineralized bovine bone(DBB), Irradiated cancellous bone(ICB) and demineralized human bone powder(DFDB). The gingival flap were advanced to cover the membranes and sutured. Seven sites experienced wound failure within 2-3weeks postsurgery resulting in membrane exposure. The animals were euthanized at 4 weeks postsurgery for histologic and histometric analysis.2) The results of this study were as follows: 1. There was little new bone formation at 4 weeks postsurgery, irrespectively of membrane exposure. 2. There was significant relationship between membrane exposure and bone graft resorption(P< 0.05), but no relation between membrane exposure and infiltrated connective tissue. 3. There was much bone graft resorption on DFDB than ICB and DBB. 4. The less exposure was on the perforated titanium membrane, the more dense infiltrated connective tissue was filled under the membrane when grafted with ICB and DBB. but there was no relationship between the rate of membrane exposure and the percentage of infiltrated connective tissue area and no relationship between the percentage of the area in the infiltrated connective tissue and in the residual bone graft. Within the above results, bone formation may be inhibited when membrane was exposed and ICB and DBB were more effective than DFDB as a bone graft material when guided bone regeneration.

Exophytic bone formation using porous titanium membrane combined with pins in rabbit calvarium / 대한치주과학회지

The purpose of this study was to evaluate exophytically vertical bone formation in rabbit calvaria by the concept of guided bone regeneration with a custom-made porous titanium membrane combined with bone graft materials. For this purpose, a total of 12 rabbits were used, and decorticated calvaria were created with round carbide bur to promote bleeding and blood clot formation in the wound area. Porous titanium membranes (0.5 mm in pore diameter, 10 mm in one side, 2 mm in inner height) were placed on the decorticated calvaria, fixed with metal pins and covered with full-thickness flap. Experimental group I was treated as titanium membrane only. Experimental group II,III,IV was treated as titanium membrane with BBM, titanium membrane with DFDB and titanium membrane with FDB. The animals were sacrificed at 8 and 12 weeks after surgery, and new bone formation was assessed by histomorphometric as well as statistical analysis. 1. Porous titanium membrane was biocompatable and capable of maintaining the regeneration space. 2. At 8 and 12 weeks, all groups demonstrated exophytic bone formation and there was a statistical significant difference among different groups only at 12 weeks. 3. The DFDB group revealed the most new bone formation compared to other groups (p<0.05). 4. At 12 weeks, DFDB and FDB groups showed the most significant resorption of graft materials (p<0.05). 5. The BBM was not resorbed at all until 12 weeks. 6. The fixation metal pin revealed excellent effect in peripheral sealing. On the basis of these findings, we conclude that a porous titanium membrane may be used as an augmentation membrane for guided bone regeneration, and DFDB as an effective bone forming graft material. The fixation of the membrane with pin will be helpful in GBR technique. However, further study is required to examine their efficacy in the intraoral experiments.