Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

BACKGROUND@#The majority of studies linking exposure to metals with certain health outcomes focus on known toxic metals. Alternatively, this study assesses the extent to which exposure to a wider range of metals during gestation is associated with childhood morbidity.@*METHODS@#We analyzed the concentrations of 25 metals found in urine samples of 111 pregnant women of Arab-Bedouin origin collected prior to birth. In addition, we collected medical records on their offspring for six years following birth, including every interaction with HMOs, local hospitals, and pharmacies.@*RESULTS@#The main types of morbidities diagnosed and treated during this period were preterm births, malformations, asthma-like morbidity, cardiovascular and behavioral problems, and obesity. Multivariable analysis showed that offspring born before term were more likely to have been exposed to elevated maternal concentrations of zinc, thallium, aluminum, manganese, and uranium, all with adjusted relative risk above 1.40 for an increase by each quintile. Likewise, children with asthma had been exposed to higher levels of magnesium, strontium, and barium at gestation, while behavioral outcomes were associated with elevated biometals, i.e., sodium, magnesium, calcium, selenium, and zinc, as well as higher levels of lithium, cobalt, nickel, strontium, cadmium, vanadium, arsenic, and molybdenum. A heatmap of adjusted relative risk estimates indicates the considerable implications that exposure to metals may have for preterm birth and developmental outcomes.@*CONCLUSIONS@#The current study shows that perinatal exposure to metals is adversely associated with pediatric morbidity. Further such analyses on additional samples are warranted.

Cómo leer y generar publicaciones científicas: exploración gráfica de datos cuantitativos: la importancia de mirar la información / How to read and generate scientific publications: in this issue: graphical exploration of quantitative data: the importance of looking at the information

Once the collection of data from a study has been completed and the respective database is available, the researcher is often impatient to answer the research question and ventures into the final steps of the analysis. However, a key stage, prior to a more complex or sophisticated statistical analysis, is data exploration and descriptive statistics. Unfortunately, the exploratory analysis of the data is often performed without much dedication, or is simply "skipped", which can have important consequences on the results obtained and lead to the report of erroneous conclusions. On the one hand, exploration allows to detect errors in the data and, if possible, to correct them from the source of origin or take them into account to make decisions about what to do with them. On the other hand, exploration allows to know the behavior of the variables evaluated in terms of their distribution (key concept in Statistics) and possible relationships among them, which is essential for subsequent descriptive and inferential analysis. The objective of this article is to show graphic tools for the exploration of quantitative data, in order to visualize its distribution and compare groups according to categories of qualitative variables.

Una vez finalizada la recolección de datos de un estudio y contado con la respectiva base de datos, es frecuente que el investigador esté impaciente por responder a la pregunta de investigación y se aventure a realizar los pasos finales del análisis. No obstante, una etapa clave, previa a un análisis estadístico más complejo o sofisticado, es la exploración de datos y la estadística descriptiva. Lamentablemente, el análisis exploratorio de los datos muchas veces es realizado sin mucha dedicación, o simplemente es "saltado", lo que puede tener consecuencias importantes en los resultados obtenidos y conducir al reporte de conclusiones erróneas. Por un lado, la exploración permite detectar errores en los datos y, si es posible, corregirlos desde la fuente de origen o tenerlos en cuenta para tomar decisiones respecto a qué hacer con ellos. Por otra parte, la exploración permite conocer el comportamiento de las variables evaluadas en términos de su distribución (concepto clave en Estadística) y posibles relaciones entre ellas, lo cual es fundamental para los análisis descriptivo e inferencial posteriores. El objetivo de este artículo es mostrar herramientas gráficas para la exploración de datos cuantitativos, con el fin de visualizar su distribución y comparar grupos según categorías de variables cualitativas.

Motivaciones de los estudiantes universitarios para continuar con su formación académica en programas de posgrado / Undergraduate students motivations to enroll in graduate programs / Motivação dos estudantes universitários para continuar seu treinamento acadêmico em programas de pós-graduação

Resumen Introducción. La educación se ha consolidado como estrategia que promueve el desarrollo del conocimiento y la formación de las comunidades y la formación avanzada constituye el medio para incrementar el capital intelectual de las sociedades. Objetivo. Identificar las principales motivaciones que tienen los estudiantes universitarios para continuar un proceso de formación avanzada en instituciones de Educación Superior. Metodología. Aplicación de un cuestionario auto-administrado a 728 estudiantes universitarios, de séptimo semestre en adelante, de la ciudad de Medellín. Se exploraron siete dimensiones relacionadas con la motivación para continuar sus estudios. Resultados. Se destacan factores motivacionales por parte de los estudiantes como la exigencia académica y las modalidades presenciales de la oferta académica para continuar con su proceso de formación avanzada. Conclusiones. Las Instituciones de Educación Superior deben considerar el contexto social en el que se enmarcan, así como sus propósitos fundacionales, para responder de manera adecuada a las necesidades de formación avanzada que se requiere en sus entornos.

Abstract Introduction. Education has been consolidated as a strategy to promote the development of knowledge and community vocational training; and the advanced academic degrees as the way to rise the intellectual capital in the society. Objective. Through an exploratory analysis, we try to identify the main undergraduate students motivations to enroll in a graduate program. Methodology. We applied a self-application questionnaire to 728 undergraduate students in the last semesters of their vocational training, at Medellin-Colombia. We explored seven dimensions related to the motivations to study a graduate program. Results. The undergraduate students' motivations to enroll in a graduate program are influenced by academic high level offered and traditional education (non-virtual) methodology of the advanced academic degrees. Conclusions. The Higher Education Institutions have to consider the social context in which they are inmerse, besides their foundational principles, to response effectively to the needed from people to enroll in graduate programs.

Resumo Introdução. A educação foi consolidada como uma estratégia que promove o desenvolvimento do conhecimento e a formação de comunidades, e o treinamento avançado é o meio para aumentar o capital intelectual das sociedades. Objetivo. Identificar, através de uma análise exploratória, as principais motivações que os estudantes universitários têm para continuar um processo de treinamento avançado em instituições de ensino superior. Metodologia. Aplicação de um questionário autoadministrado a 728 estudantes universitários, a partir do sétimo semestre, da cidade de Medellín. Foram exploradas sete dimensões relacionadas à motivação para continuar seus estudos. Resultados. Os fatores motivacionais por parte dos alunos, como o requisito académico e as modalidades face a face da oferta académica, são destacados para continuar com seu processo de treinamento avançado. Conclusões. As instituições de ensino superior devem considerar o contexto social em que são enquadradas, bem como seus objetivos fundamentais, para responder adequadamente às necessidades de treinamento avançado exigido em seus ambientes.

El control de la vida personal, social y económica: desarrollo y estudio exploratorio de una escala de medida / The Control of Personal, Social and Economic Life: Development and Exploratory Study of a Scale of Measure

En este trabajo se presenta un estudio exploratorio sobre las características psicométricas de un instrumento sobre el control de de la vida personal, analizando su estructura factorial mediante un análisis exploratorio y confirmatorio de sus dimensiones. El tamaño del estudio final fue de 8.504 entrevistas y el criterio básico de estratificación fue el distrito municipal en 21 estratos. Los resultados encontrados señalan que los ítems en cada una de las dimensiones y sus pesos factoriales son aceptables y se relacionan con enunciados genéricos sobre la atribución de control. A su vez, los índices de bondad de ajuste encontrados de cada uno de los modelos propuestos, arrojan información interesante sobre las posibilidades que este cuestionario ofrece.

The purpose of this study was to examine the characteristics psychometrics of a scale on the control of the personal life, analyzing its factorial structure by means of an exploratory and confirmatory analysis of its dimensions. The size of the final study was 8.504 interviews and the basic criterion was of stratification was the municipal district in 21 strata. The results indicate that the items in each of the dimensions and his weight factorials are acceptable and are related to generic terms of reference on the attribution of control. Also, the opposing indexes of goodness of fit of each one of the proposed models, throw interesting information about the possibilities that this scale offers.