ABSTRACT
Objectives In order to evaluate the clinical effect of manipulation combined with traditional Chinese medicine for the lateral epicondylitis.Methods A total of 150 patients with lateral epicondylitis were randomly divided into two groups, 75 patients in each group. The treatment group received manipulation combined with the TCM herbal bathing decoction, and the control group received the shock wave therapy and TCM herbal bathing decoction. Two groups were treated for 3 months. The SF-McGill scale, VAS, PPI, PRI were measured, and the clinical curative effect rate was assessed after treatment.Results The total effective rate of the treatment group was 92.0% (69/75), and the control group was 80.0% (60/75). There was statistical significant difference between two groups (χ2=8.339,P=0.039). The SF-McGill pain questionnaire scores, after treatment (26.3 ± 9.9vs. 29.4 ± 8.8, t=-4.183), one month after treatment (20.5 ± 7.7vs. 25.6 ± 6.9, t=-3.954), and 3 months after treatment (14.4 ± 8.0vs. 18.3 ± 6.7,t=-4.031) in the treatment group were significantly lower than those in the control group (P<0.05). The VAS scores after treatment (4.9 ± 1.4vs. 5.8 ± 1.3,t=-4.631), one month after treatment (3.0 ± 1.0vs. 4.1±1.2,t=-3.752), and three months after treatment (2.3 ± 1.0vs. 3.0 ± 1.3,t=-4.350) in the treatment group were significantly lower than those in the control group (P<0.05). The PPI score after treatment (2.4 ± 0.6vs. 3.1 ± 0.5,t=-7.528), one month after treatment (1.8 ± 0.6 vs. 2.5 ± 0.7,t=-6.630), and 3 months after treatment (1.1 ± 0.4vs. 1.9 ± 0.7,t=-3.425) in the treatment group were significantly lower than those in the control group (P<0.05). The PRI score after treatment (19.5 ± 8.0vs. 22.3 ± 5.7,t=-3.574), one month after treatment (13.7 ± 4.7vs. 17.3 ± 5.3,t=-3.985), and three months after treatment (9.3 ± 6.6vs. 12.5 ± 4.8,t=-1.270) in the treatment group were significantly lower than those in the control group (P<0.05).Conclusions The Manipulation combined with traditional Chinese medicine bathing therapy can relief the symptoms of lateral epicondylitis, and improve the clinical curative effect.
ABSTRACT
Melasma is a common cutaneous disorder of pigment metabolism with complex etiology and pathogenesis.Combination therapy has been preferred by dermatologists for better therapeutic effects and less adverse reactions compared with monotherapy.At present,the treatment of melasma is diversiform,mainly including oral or topical drugs,lasers or photon therapy and combination therapy,etc.Individualized treatment is recommended based on etiology,clinical course and types of melasma,as well as previous treatment history.Combination therapy,sequential therapy or supplement therapy should be included in the treatment of melasma.
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In recent years, great progress has been made in the pathogenesis of psoriasis, which has provided multiple new targets for the treatment of psoriasis, and ushered the treatment, especially topical treatment, of psoriasis to a new era. Some new targeted topical drugs with action mechanisms different from those of traditional drugs have been applied in clinical practice, which are mainly small -molecule inhibitors targeting cell signaling pathways or enzymes involved in the pathogenesis of psoriasis, such as the Janus kinase/signal transducer and activator of transcription(JAK/STAT) pathway, phosphodiesterase type 4 (PDE4), mitogen-activated/extracellular-signal-regulated kinase kinase (MEK), vascular endothelial growth factor receptor (VEGFR), tropomyosin receptor kinase A (TrKA), retinoic acid receptor-related orphan receptor γ (RORγ), and so on. At present, many phaseⅠ and Ⅱ clinical trials are conducted for these drugs. Some completed trials have shown that they have good effectiveness, safety and tolerance, providing more options for the topical treatment of psoriasis.
ABSTRACT
Objective To evaluate the efficacy of topicalJinhuang unction combined with oralSangqin mixture forthe patients with moderate to severe acnevulgaris.Methods A total of 72 patients with moderate to severe acne (Pills bury grade 2 or grade 3) were included and divided into a study group and a control group by random number table method, 36 in each group. The patients were treated for 2 months in the study group with topicalJinhuang unction combined with oralSangqin mixture, and in the control group with topical fusidic acid combined with oralSangqin mixture. The number of lesions and the Global Acne GradingSystem (GAGS) score for each patient were obtained and evaluated. The number offollicularPropionibacterium acnes was determined with real-time fluorescence quantitative polymerase chain reaction.Results After treatment, the number of papule (28.69 ± 10.50vs. 36.61 ± 10.10;t=3.262,P=0.002) was significantly less than that in the control group. The pustules was 1(0, 3) and the nodules was 0 (0, 1) in the study group, which were significantly less than those of 3(0, 15) and 0 (0, 4) in the control group (P<0.01). The GAGS scores was 13(6, 24), which was significantly less than those of 20(17, 32) in the control group significantly lower (Z=-6.482,P<0.01). The number reduction rate of follicular Propionibacterium acnes per unit area in the study group were 43.07% (-57.14%, 86.23%), which was significantly higher than that of 12.68% (-34.52%, 51.11%) in the control group (Z=-2.705,P=0.007). Conclusions TopicalJinhuang unction combined with oralSangqin mixture may reduce the damage of the skin, decrease the numbers of papule, pustules and nodules, depressPropionibacterium acnes in patients with moderate to severe acne vulgaris. TopicalJinhuang unction combined with oralSangqin mixture is superior to topical fusidic acid combined with oralSangqin mixture for the treatment of moderate to severe acne vulgaris.