ABSTRACT
Curcuma longa, commonly called Turmeric, is a plant, belonging to family Zingiberaceae (ginger family) which has been used in traditional medicine for the management of several diseases such as diabetic ulcers, rheumatic conditions, external wounds and cough. Diferuloylmethane is the most active chemical extract found in Curcumin, has been shown to exert antioxidant, antiaging, anti-inflammatory, immunomodulatory, wound healing, antitumoral and antipsoriatic effects. Delayed wound healing is a very common complication associated with diabetic patients, following extractions. Recent research has suggested that curcumin has great potential to address this.METHODSA total of 11 patients, who satisfied the inclusion criteria (RBS= <200 mg/dL) were selected from the out-patient department of Oral and Maxillofacial Surgery, FDS- RUAS. They were then divided into two groups – test and control, comprising of 6 in test group 5 in control group. Following the extraction, in the test group patients, Curcuma oral gel was placed, within the extraction socket. Both the groups were given standard post-extraction instructions. Healing of both study and control group extraction sockets were assessed on day 0, day 3 and day 7 respectively.RESULTSThe study group patients showed statistically significant reduction in the width of extraction socket on day 3 [mesial (p-value =0.03)] and day 7 [mesial (p-value =0.002)]. Central (p-value =0.03) and Distal (p-value =0.03)) and significant reduction of pain by day 7 (0.002).CONCLUSIONSCurcumin is a safe, natural herb, giving good results in the healing of the extraction socket in diabetic patients, with definite improvement in the soft tissue healing.
ABSTRACT
The aim was to describe the star volume analysis in ridge preservation using different grafting materials. Bilateral extraction of the first mandibular molars of sixteen male rabbits was performed, divided at random into four groups (n= 4 in each group) according to graft, using: blood clot (G1), xenograft (G2), pure phase beta-tricalcium phosphate (G3) and biphasic calcium phosphate (60 % HA / 40 % beta-TCP) (G4). Rabbits were euthanized at 4, 6, or 8 wk post-extraction; the trabecular bone structures was evaluated by star volume analysis. The Levene test was used to analyze variance, as was the independent sample t-test. A P-value of < 0.001 was used to establish a statistically significant. The star volume analysis of the mandibular trabecula shows that the marrow space star volume (V*m.space) was higher than the trabecular star volume (V*tr). At 6-week post-extraction, new trabecular bone was evident. At 8-week post-extraction V*tr increase in all groups and the V*m.space diminish, suggesting coarsening of the internal architecture. In G2, some trabecular bone was observed in the central region. In G3, most of the socket regions were occupied by newly formed and loose trabecular bone and in the G4, the sockets were almost entirely filled with trabecular bone. Star volume analysis is adequate to analysis of bone patterns formation using bone substitutes.
El objetivo de esta investigación fue describir el volumen estrella en preservación alveolar utilizando diferentes injertos óseos. La exodoncia bilateral del primer molar mandibular de 16 conejos machos fue realizada, dividiéndolos en 4 grupos (n= 4 en cada grupo) de acuerdo al injerto utilizado, siendo: coágulo sanguíneo (G1), xenoinjerto (G2), beta-tricalcio fosfato puro (G3) y fosfato de calcio bifásico (60 % HA / 40 % beta-TCP) (G4). Los conejos fueron sometidos a eutanasia a las 4, 6 u 8 semanas post exodoncia; el trabeculado óseo fue evaluado por medio del volumen estrella. La prueba de Levene fue utilizado para el análisis de varianza y luego la prueba t-test para muestras independientes. El valor de P menor a 0.001 fue establecido como significancia estadística. El análisis del volumen estrella del trabeculado mostró que el espacio medular de volumen estrella (V*m.space) fue mayor que trabeculado (V*tr). A 6 semanas post exodoncia, nuevo trabeculado óseo fue evidente. A las 8 semanas post exodoncia V*tr aumenta en todos los grupos y el V*m.space disminuye, sugiriendo un engrosamiento de la arquitectura interna. En el grupo G2, algún trabeculado óseo fue observado en la región central. En el G3, la mayoría del alveolo fue ocupado por nuevo hueso y perdió trabeculado óseo y en G4, el alveolo fue ocupado casi enteramente por hueso trabecular. El análisis de volumen estrella es adecuado para analizar el modelo de formación ósea utilizando sustitutos óseos.