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Background: Pulmonary function parameters can be altered with the change in body position. Therefore, physiological basis behind such consequent influence is essential to be understood. Pulmonary function tests are generally conducted in the erect sitting posture as it is more feasible and comfortable. However, bedridden patients are unable to do so and only few studies are found on recumbent postures. Thus, to comfort such patients in breathing, need arises to meet this requisite investigation to conclude the best recumbent body posture. Aim and Objectives: To compare and assess forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC ratio, forced expiratory flow of during 25�% expiration (FEF25�%, and peak expiratory flow rate (PEF) in the Supine, Crook-lying and Fowler抯 position. Materials and Methods: The present research was carried out on 128 healthy adults to measure FVC, FEV1, FEV1/FVC ratio, FEF25�% and PEF using a computer-based spirometer in the Supine, Crook-lying and Fowler抯 position. One-way Analysis of Variance with Tukey HSD post-hoc test was utilized between each body postures by evaluation of their mean values. Results: This study consisted of 128 subjects (males 57, females 71) with mean age of 21.62 � 1.75 years, mean weight 59.71 � 9.97 kg, mean height 164.68 � 9.30 cm and Body mass index 21.91 � 2.38 kg/m2. Fowler抯 posture showed significantly (P < 0.05) higher value in all spirometric parameters as compared to other two postures. Outcome of the study showed all spirometric parameters value- greater in the Fowler抯 posture than that of Supine or Crook-lying posture. Conclusion: The implication of this research is that it will meet the need of selection of the most suitable substitute posture for better pulmonary functioning in bedridden people.
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Background: The aim of study was to to assess respiratory indices in underweight and overweight young group (subcategory) and compare the same with normal weight controls (in the age group of 18 to 30 years). Methods: In the present study 210 subjects were included, aged between 18 yrs-30 yrs after applying inclusion and exclusion criteria. The groups (n=210, case= 132 and control= 78) are divided into group A, B, C, D, E and F respectively each having 21, 78, 40. 35, 29 and 7 subjects on the basis Of international classification of BMI. Results: In our study mean predicted value of FEV1/FVC ratio in group A 84.02±31.24(underweight), group C 86.83±29.46(pre-obese), group D 92.10±13.31(obese class 1),group 93.72±9.49 ( obese class 2) and group F191.02±22.24( obese class 3), when compared to control group B 87.95±26.77 was found to be decreased in group A and increased in other obese group , but it was within normal range in all groups and no statistical difference found between different groups (P value>0.05). Conclusion: After analyzing the data, we did not observe any statistically significant difference in FEV1/FVC between the control and underweight and overweight group.
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Introduction: The diaphragm is man's main respiratory muscle. The role of the abdominal muscles is seen in both quiet and forceful breathing. Abdominal muscle function could be affected in subjects with back pain. Few studies are done about the relation between expiratory muscle strength and pulmonary function. So the aim of this study was to evaluate the correlation of abdominal muscle strength with pulmonary function in patients with low back pain. Materials and methods: Sixty subjects with low back pain were included in the study. Subjects with history of acute or chronic respiratory disorders were excluded. Abdominal muscle strength was measured by curl up test and FEV1/FVC and peak expiratory flow rate (PEFR) was measured to assess pulmonary functional. Results: Using Spearman test for correlation between abdominal muscle strength and FEV1/FVC (r= - 0.27, p=0.03), and between abdominal muscle strength and PEFR (r=0.34, p=0.007) was seen. Conclusion: There was a weak correlation between abdominal muscle strength and pulmonary function in subjects of low back pain.
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Background: The importance of pulmonary rehabilitation (PR) as a therapeutic measure for COPD patients is well known. Objective: To evaluate the effects of PR program by pursed lip breathing (PLB) and diaphragmatic breathing (DB) on FVC, FEV1, FEV1/FVC ratio in male patients with moderate stable COPD. Methods: This prospective study was conducted in the Department of Physiology, BSMMU, Dhaka from July 2010 to June 2011 on 116 male stable moderate COPD patients aged 50 to 65 years. They were enrolled from the out patient department of the Department of Medicine of BSMMU and NIDCH Dhaka. They were grouped as control (56 patients without PR) and experimental (60 patients with PR). The experimental patients were advised to perform PR program for 30 minutes duration per session at home twice daily, for consecutive 60 days along with the standard drug treatment of COPD. On the contrary, the control patients were advised to continue their standard drug treatment alone for consecutive 60 days. For the assessment of spirometric lung function status, FVC, FEV1, FEV1/FVC ratio of all subjects were recorded on day 0 and day 60 for both the group by a portable digital MicroDL Spirometer and the statistical analysis was done by independent sample ‘t’ test and paired Student’s ‘t’ test. Results: FVC and FEV1 value were significantly increased in comparison to the control patients after 60 days of follow up. On the other hand, post exercise value of FEV1/FVC ratio was decreased but it was not statistically significant. Conclusion: The study reveals improvement of lung functions with this sort of combination of PR program in stable COPD patients.
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Background: The knowledge of pulmonary function tests (PFTs) is a basic requirement to understand the respiratory physiology for all medical physiologists and clinicians Pulmonary Function Tests provide objective evidence of nature and severity of lung disease. Objective: To observe FEV1, FVC, FEV1/FVC ratio in healthy male and female school children from 7-14 years of age in Western Rajasthan and to find out the relationship of FEV1, FVC, FEV1/FVC ratio with their height, weight, BSA and sex Methods: The present study was carried out on 112 male and 76 female children of 7-14 years. For Pulmonary Function Tests, FEV1, FVC and FEV1/FVC along with anthropometric data of each subject was recorded.. Data were analyzed by unpaired t test, Pearson correlation coefficient test, simple and multiple regression analysis. Results: FVC and FEV1 values were found significantly (p<0.001) higher in male than those of female. Significant positive correlation of FVC and FEV1 whereas non significant negative correlation of FEV1/FVC were observed with age, height, weight, body surface area in all children. Conclusion: As the weight, age, height and BSA of subjects increases, FEV1 and FVC increases while FEV1/FVC ratio decreases in both the sexes.
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Background: End-stage renal disease causes multiple pulmonary complications and lung functions are decreased in ESRD patients undergoing maintenance haemodialysis. Objectives: To observe FVC, FEV1, FEV1/FVC ratio and FEF25-75% in ESRD patients undergoing maintenance haemodialysis to evaluate their lung functions status. Methods: This cross sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from July 2011 to June 2012. For this, 30 ESRD patients aged 25-55 years undergoing maintenance haemodialysis with less than 1 year duration were studied and 30 age, sex matched healthy subjects were taken as control. Patients were selected from the Nephrology department of BSMMU, Dhaka. FVC, FEV1, FEV1/FVC ratio and FEF25-75% were measured by a Digital Spirometer. For statistical analysis Independent Sample‘t’ test and One way ANOVA test were performed as applicable. Results: The mean percentage of predicted values of FVC, FEV1 and FEF25-75% were significantly lower in patients except FEV1/FVC ratio which was almost similar to control. 63.33% patients had restrictive and 36.67% patients had both restrictive and obstructive (small airway obstruction) feature. Conclusion: This study concluded that some pulmonary functions were markedly reduced in ESRD patients undergoing maintenance haemodialysis. In addition most of the patients were suffering from restrictive and some of them were affected with both obstructive and restrictive type of pulmonary disorders.
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PURPOSE: Airway remodeling may be responsible for irreversible airway obstruction in asthma, and a low post-bronchodilator FEV1/FVC ratio can be used as a noninvasive marker of airway remodeling. We investigated correlations between airway wall indices on computed tomography (CT) and various clinical indices, including post-bronchodilator FEV1/FVC ratio, in patients with asthma. METHODS: Volumetric CT was performed on 22 stable asthma patients who were taking inhaled corticosteroids. Airway dimensions were measured at four segmental bronchi using in-house software based on the full-width/half-maximum method. Parameters included luminal area, wall thickness (WT), wall thickness percentage (WT%), wall area percentage (WA%), bronchial-to-arterial diameter (BA) ratio on inspiration CT, airway collapsibility (AC), and air trapping index (ATI). Correlations were analyzed between CT parameters and clinical indices, including %FEV1, FEV1/FVC, FEF25-75%, and post-bronchodilator FEV1/FVC ratio. RESULTS: Post-bronchodilator FEV1/FVC showed significant correlations with WT%, WT, BA ratio, AC, and ATI (r=-0.503, -0.576, 0.454, 0.475, and -0.610, respectively). WT showed negative correlations with FEV1/FVC and FEF25-75% (r=-0.431 and -0.581), and WT% was negatively correlated with %FEV1, FEV1/FVC, and FEF25-75% (r=-0.434, -0.431, and -0.540, respectively). WA% showed correlations with FEF25-75% and body mass index (r=-0.459 and 0.453). The BA ratio was positively correlated with %FEV1 (r=0.459) and FEF25-75% (r=0.479). AC showed strong positive correlation with FEV1/FVC (r=0.592), and ATI showed negative correlations with FEV1/FVC (r=-0.534) and FEF25-75% (r=-0.591). CONCLUSIONS: WT%, WT, BA ratio, and AC on inspiration and expiration CT are good indices for measuring airway remodeling defined by post-bronchodilator FEV1/FVC in stable asthma patients treated with inhaled corticosteroids.