ABSTRACT
Objective To discuss the influence of Recipe Wenzhongxiaotan to S180 bearing cancer mouse interfered by cold pathogenic factor and study correlation factor index. Methods To treat S180 bearing cancer mouse by interfere in ice water with Recipe Wenzhongxiaotan, with the control of Recipe Xiaotansanjie group and chemotherapy group, the change of morphology and rectal temperature in mouse, growth velocity and volume in tumor after treatment with Recipe Wenzhongxiaotan were observed, and TXB2 in plasma of mouse was detected by RIA. Results It showed late and short in chilly morphology and rectal temperature amplitude small than other groups in Recipe Wenzhongxiaotan group. The rate to restrain tumor growth was 86.69%, 75.29%, 87.55% in Recipe Wenzhongxiaotan group, Recipe Xiaotansanjie group and chemotherapy group (FT-207), respectively. TXB2 was near in Recipe Xiaotansanjie group and chemotherapy group and the difference was significant compared cold model group (P 0.05) in Recipe Wenzhongxiaotan. Conclusions It may be restrain tumor growth which S180 tumor-bearing mice interfered by cold pathogenic factor and degrade TXB2 in Recipe Wenzhongxiaotan, the rate to restrain tumor growth was near to FT-207 and Recipe Xiaotansanjie.
ABSTRACT
AIM: To observe the effects of diosgenin on enhancing efficacy and reducing toxicity of FT-207 in tumor-bearing mice. METHODS: The inhibitory rate on tumor growth and immune function of the in tumor-bearing mice model of transplanting MFC,HepA,H_22 and S_180 tumor were measured. RESULTS: Diosgenin had significant restraining effects on MFC in mouse.It could enhance the activity of macrophage and the level of serum hemolysin. CONCLUSION: Diosgenin can enhance the anti-tumor effect of FT-207.It can also improve the immunological function and reduce the adverse reactions of chemotherapy.