ABSTRACT
Subject(s)
Blepharospasm , Botulinum Toxins , Botulinum Toxins, Type A , Clostridium botulinum , Facial Asymmetry , Facial Nerve , Hyperhidrosis , Hypertrophy , Masseter Muscle , Orthognathic Surgery , Paralysis , Rejuvenation , Strabismus , Temporomandibular JointABSTRACT
Preserved particulate fascia lata, derived from screened human cadavers, has recently become available. This injectable form of the material can be injected when soft tissue augmentation is desired. Historically, preserved fascia grafts have proven efficacy and an excellent safety record over the past 70 years. Deep facial wrinkles, especially grabellar frown and nasolabial fold remain a difficult problem to be corrected. Clinical subjects(N=35; 29 women, 6 men, age range 29 - 48 years) requiring soft tissue augmentation to correct deep facial wrinkles were injected with a total of 53 syringes of freeze-dried, irradiated, human cadaver fascia lata. After an subdermal pocket was created at each depressed site, two different preparations -2.0 mm, 0.5 mm particle sizes-were hydrated in 2 - 3 cc normal saline and injected with needles ranging in size from 16 to 20 gauge. The patients were followed for 9 months (1-17 months) after implantation without incidence of infection, allergic reaction, or acute rejection. After the treatment day, patients experienced no further discomfort. No dermal inflammation was evident and the local ecchymosis associated with infections was minor. Soft tissue augmentation was evident 6 months after grafting or longer in most cases. Ultimately, a predictable improvement in skin contour occurred in the majority of the facial wrinkles.Preserved particulate fascia lata grafting is a simple, safe, controlled technique for correction of facial wrinkles. This patient series indicates that injectable preparations of preserved fascia lata have the high biocompatibility as experienced with whole-tissue implants.
Subject(s)
Female , Humans , Male , Cadaver , Ecchymosis , Fascia Lata , Fascia , Hypersensitivity , Incidence , Inflammation , Nasolabial Fold , Needles , Skin , Syringes , TransplantsABSTRACT
BACKGROUND: Botulinum toxin type A is being widely used for the treatment of facial wrinkles affected by facial expression muscles. Due to the sudden and exponential surge in popularity of its use for facial wrinkles, there are scanty reports of facial wrinkles treated with botulinum toxin type A especially in Asians. OBJECTIVE: This study was performed to investigate the clinical features of facial wrinkles affected by facial expression muscles and the effects of botulinum toxin A on the treatment of wrinkles. METHODS: Medical records of 61 patients with facial wrinkles treated with botulinum toxin type A were reviewed. Demographic profiles of the patients, the age of onset of facial wrinkle, the distributions of facial wrinkles, treatment dose of botulinum toxin type A, side effects, and follow up data were analyzed. RESULTS: Female patients were predominant(93.4%) than male patients(6.6%). The mean age of the patients was 41.3 years. Crow's feet were the most frequently treated site of facial wrinkles. Average number of treated sites were 2.38. Side effect profiles were similar as previous reports in Cauca sians. The number of patients who took the regular retreatment was less than expected. CONCLUSION: The clinical profiles of wrinkle patients in Koreans treated with botulinum toxin A were assessed. We think it is one of the effective treatment modalities for antiwrinkling.