A Pilot Study on Estimation of Serum Uric Acid Level among Euglycemic With Family History of Diabetes and no Family History of Diabetes

Background: Type II Diabetes mellitus has emerged as aglobal public health problem with more effect on developingworld. India is considered to become epicentre of DM in nearfuture. Serum uric acid is a by-product of purine metabolism.Most of the studies provide a positive relationship betweenhyperglycemia & hyperuricemia.Objectives: To co-relate the level of serum uric acid ineuglycemic persons having family history of DM and in personshaving no family history of DM and to assess the level ofHbA1c among these two groups.Materials and Methods: Present study was undertaken atMGM Medical College, Jamshedpur and Sadar Hospital,Jamshedpur with a sample size of 60 (30 in each group).Results: The present study didn’t find any significantdifference in serum uric acid between two groups although asignificant difference was observed in HbA1c in both groups.

Family history of diabetes and parental consanguinity: important risk for impaired fasting glucose in South East Asians / Historia familiar de diabetes y consanguinidad de los padres: riesgo importante para la glucosa en ayunas alterada en Asiáticos Sudorientales

OBJECTIVE: Offsprings of Type 2 diabetics have increased risk of metabolic disturbances. The aim of the study is to assess the potential effect of family history of Type 2 diabetes (FHD) and parental consanguinity on fasting plasma glucose (FPG) levels. SUBJECTS AND METHODS: Non-diabetic offsprings of one or both parents with Type 2 diabetes and healthy controls of comparable age, without a FHD were the subjects of this study. Family history of Type 2 diabetes was defined by the presence of Type 2 diabetes in one or both parents of the subject. Consanguinity was defined as history of marriage with a first cousin. Fasting plasma glucose levels were determined in cases and controls. RESULTS: Impaired fasting glucose (IFG) was identified in 42% ofsubjects with FHD and in 14% without FHD. We found a strong independent association of FHD with impaired fasting glucose in both males and females by logistic regression analysis after adjusting the data for age, gender and body mass index (BMI). Parental consanguinity modifies the effect of FHD on IFG. CONCLUSION: We concluded that family history of diabetes and parental history of consanguinity determine the risk for impaired fasting glucose in this study population.

OBJETIVO: Los hijos con diabetes de Tipo 2 tienen un riesgo mayor de trastornos metabólicos. El objetivo de este estudio es evaluar el efecto potencial de la historia familiar en la diabetes Tipo 2 (HFD) y la consanguinidad de los padres en los niveles de glucosa plasmática en ayunas (GPA). SUJETOS Y MÉTODOS: Los hijos no diabéticos de uno o ambos padres con diabetes de Tipo 2 y controles sanos de edad comparable, sin HFD, constituyeron los sujetos de este estudio. La historia familiar de diabetes de Tipo 2 se definió por la presencia de la diabetes de Tipo 2 en uno o ambos padres del sujeto. La consanguinidad se definió como la historia del matrimonio con un primer primo o prima. Los niveles de glucosa plasmática fueron determinados en los casos y los controles. RESULTADOS: La glucosa en ayunas alterada (GAA) fue identificada en el 42% de los sujetos con HFD y en 14% sin HFD. Se halló una fuerte asociación independiente fuerte de HFD con la glucosa en ayunas alterada tanto en varones como en hembras, mediante el análisis de regresión logística después de ajustar los datos de edad, género e índice de masa corporal (IMC). La consanguinidad de los padres modifica el efecto de HFD sobre la GAA. CONCLUSIÓN: Se llegó a la conclusión de que la historia familiar de diabetes y la historia de consanguinidad de padre y madre determina el riesgo de glucosa en ayunas alternada en la población bajo estudio.

Investigation in early-phase secretion function between islet α cells and β cells in subjects with normal glucose tolerance and family history of diabetes / 中华内分泌代谢杂志

To compare the early-phase secretion between islet α cells and β cells in subjects with normal glucose tolerance and to explore the influencing genetic factors on the function of islet cells.40 subjects with normal glucose tolerance and family history of diabetes ( FH+ ) and 55 healthy volunteers without family diabetes history ( FH ) were collected.Fasting and L-arginine stimulating insulin,glucagon,and tasting free fatty acid,as well as other indicators were determined in all subjects.Insulin resistance was evaluated by homeostasis model assessment for insulin resistance.After adjnsting for sex,age,and body mass index,the insulin secretion peak of the two groups reached both at two min,and began to decline at four min,the peak multiple of FH+group was significantly less than that of FH-group (7.29 vs 8.88,P＜0.05) ; glucagon secretion peak of both groups reached at two min and began to decline by four min.Fasting glucagon and peak multiple were not significantly different (P＞0.05) ; The ratio of fasting insulin to fasting glucagon of the two groups was without significantly difference ( P＞0.05 ).Under diabetes genetic background,the function of β cells decreases even in subjects with normal glucose tolerance.

Resistencia a la insulina e historia familiar de diabetes en niños y adolescentes obesos con acantosis nigricans y sin ella / Insulin resistance and family history of diabetes in obese children and with and without acanthosis nigricans

Introducción: las complicaciones metabólicas más importantes para la morbilidad y mortalidad que se derivan de la obesidad tienen como común denominador la resistencia a la insulina. Objetivo: determinar la existencia de resistencia a la insulina e historia familiar de diabetes en un grupo de niños y adolescentes obesos con y sin acantosis nigricans. Métodos: se estudiaron 46 sujetos obesos con y sin acantosis nigricans (21 varones y 25 hembras), con edades entre 4 y 16 años, procedentes de la consulta de endocrinología del Hospital Pediátrico Docente William Soler, en el período de noviembre de 2006 a febrero de 2007. Se les realizó, además de examen físico y anamnesis, prueba de tolerancia a la glucosa con determinación de glucemia e insulinemia en ayunas y a las 2 h. Se utilizó como criterio de resistencia a la insulina el índice HOMA. Resultados: la mayoría de los pacientes (36 sujetos) presentaron resistencia a la insulina, independientemente de la presencia o no de acantosis nigricans, que no estuvo relacionada con el grado de obesidad ni con el pliegue tricipital de grasa, pero sí con la historia familiar de diabetes tipo 2. La presencia de acantosis nigricans estuvo relacionada con el grado de obesidad. Se encontró un 13 por ciento de pacientes con criterios de prediabetes. Conclusiones: la obesidad y la historia familiar de diabetes tipo 2 en los niños y adolescentes se relacionan con la presencia de resistencia a la insulina, independientemente de la presencia de acantosis nigricans(AU)

Introduction: the more important metabolic complications for morbidity and mortality derived from obesity have in common the insulin resistance. Objective: to determine the insulin resistance and the family history of diabetes in a group of obese children and adolescents with and without acanthosis nigricans. Methods: forty six obese subjects with and without acanthosis nigricans (21 boys and 25 girls) aged between 4 and 16, from the William Soler Teaching Children Hospital were studied from November, 2006 to February, 2007. Also, they underwent a physical examination and anamnesis, a test of glucose tolerance with determination of fasting glycemia and insulinemia and at 12 hours. As criterion of insulin resistance the HOMA index was used. Results: most of patients (36 subjects) had insulin resistance, independently of the acanthosis nigricans presence, which was neither related to the obesity degree nor the fat tricipital fold, but yes to the family history of type 2 diabetes. The presence of acanthosis nigricans was related to the obesity degree. There was a 13 percent of patients with pre-diabetes criteria. Conclusions: the obesity and the family history of type 2 diabetes in children and adolescents were related to presence of insulin resistance, independently of presence of acanthosis nigricans(AU)

The Study on the Impact of Family History of Hypertension and Diabetes Mellitus on the Genetic Phenotype in Normoglycemic Subjects / 中国慢性病预防与控制

Objective To explore the impact of family history of hypertension and diabetes mellitus on the phenotype of insulin resistance and the ?-cell function in normoglycemic subjects. Methods 275 normoglycemic subjects were divided into four groups according to family history of hypertension and diabetes,namely group combined with family history of hypertension and diabetes (H+D+group),group without family history of hypertension and diabetes (H-D-group),group without family history of hypertension but with diabetes (H-D+group),group with family history of hypertension but without diabetes (H+D-group). The homeostasis model assessment of insulin resistance(HOMA-IR) and the function of insulin secretion (HOMA-?) was used to estimate insulin resistance and ?-cell function. Results The mean body mass index,waist to hip ratio,blood pressure,triglycerides,cholesterol and HOMA-IR were significantly higher in H+D+group than those in H-D-group,but HDL,HOMA-? were significantly lower in H+D+group than those in H-D-group (all P