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@#Introduction: Hypertension is a polygenic disease that caused 45% of deaths. Various genes have been engaged with the pathogenesis of hypertension. One of these genes affects sodium homeostasis in the kidney, including the ACE I/D gene polymorphism. The present study aimed to investigate the relationship of family history of hypertension and ACE I/D gene polymorphism with the incidence of hypertension in coastal communities of Kendari City. Methods: The study was conducted using a case-control study design. The case group was hypertensive patients based on medical diagnostic by doctors, while the control group was healthy individuals without any records on hypertension. As many as 70 individuals residing in the coastal area of Kendari City were involved as samples of the study. Both case and control groups consisted of 35 individuals. Data collection techniques were carried out experimentally using the PCR-RFLP method. Results: The prevalence of I allele was found in individuals with a family history of hypertension (72.1%) as compared to the D allele (27.9%). The study also found a significant correlation between the family history of hypertension and ACE I/D gene polymorphism (p-value 0.001). However, there was no significant relationship between ACE I/D gene polymorphism and the incidence of hypertension in this population (p-value 0.631). Conclusion: Family history of hypertension was a risk factor for the incidence of hypertension. On the other hand, the polymorphism of ACE I/D gene was a protective factor towards the incidence of hypertension.
ABSTRACT
@#Introduction: Hypertension is a polygenic disease that caused 45% of deaths. Various genes have been engaged with the pathogenesis of hypertension. One of these genes affects sodium homeostasis in the kidney, including the ACE I/D gene polymorphism. The present study aimed to investigate the relationship of family history of hypertension and ACE I/D gene polymorphism with the incidence of hypertension in coastal communities of Kendari City. Methods: The study was conducted using a case-control study design. The case group was hypertensive patients based on medical diagnostic by doctors, while the control group was healthy individuals without any records on hypertension. As many as 70 individuals residing in the coastal area of Kendari City were involved as samples of the study. Both case and control groups consisted of 35 individuals. Data collection techniques were carried out experimentally using the PCR-RFLP method. Results: The prevalence of I allele was found in individuals with a family history of hypertension (72.1%) as compared to the D allele (27.9%). The study also found a significant correlation between the family history of hypertension and ACE I/D gene polymorphism (p-value 0.001). However, there was no significant relationship between ACE I/D gene polymorphism and the incidence of hypertension in this population (p-value 0.631). Conclusion: Family history of hypertension was a risk factor for the incidence of hypertension. On the other hand, the polymorphism of ACE I/D gene was a protective factor towards the incidence of hypertension.
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Objective: To investigate the impact for family history of hypertension on masked hypertension (MH) morbidity with relevant cardiac damage. Methods: Our research included in 3 groups: MH group, n=250 consecutive patients treated in our hospital from 2010-01 to 2015-04, Hypertension group, n=250 and Control group, n=250 subjects with normal blood pressure. The family history of hypertension, general clinical information, routine biochemical indexes and the findings of echocardiography were studied and compared among different groups. Results: ① There were 70 (28%) patients with family history of hypertension in MH group, 87 (34.8%) in Hypertension group and 26 (10.4%) in Control group. The ratio of family history of hypertension in MH group was higher than Control group, P0.05. Logistic regression analysis presented that family history of hypertension and body mass index were positively related to the morbidities of MH (r=1.468, r=0.173) and hypertension (r=1.195, r=0.086). ② Compared with Control group, MH group had increased left ventricular mass index (85.64 ± 17.7) g/m2 vs (80.50 ± 15.53) g/m2 and the maximum blood flow velocity of aortic valve (115.74 ± 16.54) cm/s vs (112.40±14.21) cm/s, all P<0.05. In MH group, compared with those without family history of hypertension, the patients with family history had the higher left ventricular mass index (89.22 ± 19.08) g/m2 vs (84.25 ± 16.99) g/m2 and the maximum blood flow velocity of aortic valve (119.19 ± 14.97) g/m2 vs (114.39 ± 16.96) g/m2, all P<0.05. Conclusion: The subjects with family history of hypertension had the higher risk of MH morbidity with more severe cardiac damage.
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Background: As obese population is increasing nowadays, research on blood pressure of obese children is being performed more frequently. However, there are only few research related to factors about blood pressure among obese children in Korea. The purpose of this study was to analyze the factors affecting blood pressure of obese children and adolescents. Methods: The subjects were elementary and middle school students diagnosed with obesity (n=1716). Height, weight, waist circumstance, body fat percent, blood pressure were measured. Family history and sexual maturity were investigated through the questionnaire. The relationship between the factors and the increase of blood pressure was analyzed. Results: Body weight was the most powerful factor among to factors related to increase of blood pressure (male r=0.45, P<0.05, female r=0.37, P<0.05). Also, height, percentage weight for height (PWH), body mass index (BMI) and waist circumference was correlated with the blood pressure. In multiple regression analysis, family history of hypertension and the sexual maturity were significant determinants of blood pressure in males after adjusting for weight. However, body fat percent was a significant determinant in females. Conclusion: Body weight was the most important factor which increased the blood pressure in obese children and adolescents in both sexes. But males and females had different factors related to the increase of blood pressure with the exception of body weight.
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Adolescent , Child , Female , Humans , Male , Adipose Tissue , Blood Pressure , Body Mass Index , Body Weight , Hypertension , Korea , Obesity , Waist Circumference , Surveys and QuestionnairesABSTRACT
Objective To explore the impact of family history of hypertension and diabetes mellitus on the phenotype of insulin resistance and the ?-cell function in normoglycemic subjects. Methods 275 normoglycemic subjects were divided into four groups according to family history of hypertension and diabetes,namely group combined with family history of hypertension and diabetes (H+D+group),group without family history of hypertension and diabetes (H-D-group),group without family history of hypertension but with diabetes (H-D+group),group with family history of hypertension but without diabetes (H+D-group). The homeostasis model assessment of insulin resistance(HOMA-IR) and the function of insulin secretion (HOMA-?) was used to estimate insulin resistance and ?-cell function. Results The mean body mass index,waist to hip ratio,blood pressure,triglycerides,cholesterol and HOMA-IR were significantly higher in H+D+group than those in H-D-group,but HDL,HOMA-? were significantly lower in H+D+group than those in H-D-group (all P