Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review

Abstract BACKGROUND: Severe acute respiratory syndrome coronavirus 2 has several mechanisms of action related to inflammatory responses, especially in individuals diagnosed with obesity. This hyperinflammatory clinical profile resulting from the association between obesity and coronavirus disease 2019 (COVID-19) may be attenuated by regular physical activity. OBJECTIVE: The aim of this study was to review the evidence on the consequences of physical inactivity and physical activity on COVID-19 in patients with obesity. DESIGN AND SETTING: Narrative review at the Bahiana School of Medicine and Public Health in Salvador, Brazil. METHODS: We searched evidence on the association of COVID-19 with physical activity and obesity using the following keywords: "covid-19," "physical activity," and "obesity". The databases used were MEDLINE (PubMed), ScienceDirect, and Virtual Health Library. Studies published from 2019 to 2021 and available in Portuguese, English, and Spanish were included. The final search was conducted on September 26, 2021. RESULTS: We identified 661 studies in the database, among which 71 were considered for inclusion in the narrative review of the molecular aspects of COVID-19 and its relationship with physical activity and obesity. CONCLUSION: This literature review enabled the perception of the relationship between the molecular mechanisms of COVID-19 and obesity. Regular physical activity had various benefits for the inflammatory condition of the studied population, highlighting moderate-intensity.

¿Diagnóstico o estigma? Problematizar la enfermedad desde un acercamiento duoetnográfico

Objetivo: El propósito de este escrito es hablar sobre las construcciones socioculturales alrededor de la enfermedad. La principal preocupación es contribuir a desmontar desde nuestras vivencias como investigadoras y mujeres diagnosticadas, el estigma que impregna la vida cotidiana de las personas como nosotras: obesas o con VPH (virus del papiloma humano). Metodología: Mediante la metodología conocida como duoetnografía, en la que dos individuos narran experiencias compartidas para profundizar sobre un fenómeno sociocultural, presentamos una serie de cavilaciones que cuestionan el lugar social en el que se nos coloca al ser valuadas como enfermas. Resultados: Encontramos, a partir de nuestras reflexiones simultáneas, tres epifanías que se relacionan, primero, con el estigma biomédico, luego, con el estigma personal y, después, con el estigma sociocultural. Una cuarta epifanía expone las consideraciones de aprendizaje conjunto durante el proceso de convivencia académica de las autoras. Conclusión: Nos interesa, sobre todo, dejar una invitación a considerar críticamente el estigma, nos preocupa hablar de cuidado y apuntar las prácticas discriminatorias más que negar nuestros diagnósticos.

Objetivo: O objetivo deste trabalho é falar sobre as construções socioculturais que envolvem a doença. A principal preocupação é contribuir para desmontar, desde nossas experiências como pesquisadores e mulheres diagnosticadas, o estigma que permeia a vida diária de pessoas como nós: obesas ou com HPV (Human Papilloma Virus). Metodologia: Por meio da metodologia conhecida como duoetnografia, na qual dois indivíduos narram experiências compartilhadas a fim de aprofundar um fenômeno sociocultural, apresentamos uma série de reflexões que questionam o lugar social em que somos colocados quando somos categorizadas como doentes. Resultados: Encontramos, a partir de nossas reflexões simultâneas, três epifanias que se relacionam primeiro com o estigma biomédico, depois com o estigma pessoal e depois com o estigma sociocultural. Uma quarta epifania expõe as considerações de aprendizagem conjunta durante o processo de convivência acadêmica das autoras. Conclusão: Estamos interessados, acima de tudo, em deixar um convite para considerar criticamente o estigma, estamos preocupadas em falar de cuidados e apontar práticas discriminatórias em vez de negar nossos diagnósticos.

Objective: The purpose of this paper is to talk about the sociocultural constructions around the disease. The main interest is to contribute to dismantle from our experiences as researchers and diagnosed women, the stigma that permeates the daily lives of people like us: obese or with HPV (Human Papilloma Virus). Methodology: Through the methodology known as duoethnography, in which two individuals narrate shared experiences to study in detail a sociocultural phenomenon, we present a series of thoughts that question the place in which we are placed when we are valuated as sick. Results: We found, from our simultaneous reflections, three epiphanies that relate first to biomedical stigma, then to personal stigma and then to sociocultural stigma. A fourth epiphany expounds joint learning considerations during the authors' academic shared experience. Conclusion: We are interested, above all, in leaving an invitation to critically consider stigma, we are concerned with talking about care and pointing out discriminatory practices rather than denying our diagnoses.

Corpo feminino e sexualidade: gordura, feiura e exclusão social / Female body and sexuality: fatness, ugliness and social exclusion / Corps féminin et sexualité: graisse, laideur et exclusion sociale

O presente artigo busca investigar o lugar do corpo na atualidade, uma vez que ele nunca é totalmente apreendido pelos dispositivos culturais que possibilitem sua submissão completa às expectativas sociais. Neste sentido, é legítimo afirmar haver certa dificuldade epistêmica, no que tange às disputas de narrativas em torno do corpo gordo. Culturalmente legitimado, observamos um discurso dominante que sugere a responsabilização do sujeito por sua condição corporal. De modo análogo, a criminalização da gordura aumenta quando a sobrepomos à questão de gênero, conforme ilustrarão algumas vinhetas; fruto de entrevistas realizadas anteriormente pela autora, na pesquisa que desenvolve sobre corpo feminino, imagem, sofrimento psíquico e regulação social. A "feiura" ou o "estranho", muitas vezes poderão ser tomados como uma mensagem, cuja força reside, justamente, na sua surpreendente apresentação. Neste sentido, as práticas corporais podem ser compreendidas em um cenário de indiferenciação, na estetização da vida cotidiana, de sujeição ao discurso do outro, mas também, como uma contestação, como problematização do estatuto do corpo na contemporaneidade.

This article seeks to investigate the place of the body nowadays, since it is never fully apprehended by cultural devices that allow its complete submission to social expectations. In this sense, it is legitimate to affirm that there is some epistemic difficulty, regarding the disputes of narratives around the fat body. Culturally legitimized, we observe a dominant discourse that suggests the responsibility of the subject for body condition. Similarly, the criminalization of fat increases when we overwrite it the issue of gender, as some vignettes will illustrate; the result of interviews previously conducted by the author, in the research she develops on the female body, image, psychic suffering and social regulation. The "ugliness" or the "strange" can often be taken as a message, whose strength lies precisely in its surprising presentation. In this sense, body practices can be understood in a scenario of indifferentiation, in the instantiation of everyday life, of subjection to the discourse of the other, but also, as a contestation, as a problematization of the body's status in contemporaneity.

Cet article cherche à étudier la place du corps de nos jours, car il n'est jamais complètement appréhendé par des dispositifs culturels qui permettent sa soumission complète aux attentes sociales. En ce sens, il est légitime d'affirmer qu'il existe une certaine difficulté épistémique, en ce qui concerne les disputes de récits autour du corps gras. Culturellement légitimé, nous observons un discours dominant qui suggère la responsabilité du sujet pour son état corporel. De même, la criminalisation des graisses augmente lorsque nous écrasons la question du genre, comme certaines vignettes l'illustreront; le résultat d'entretiens précédemment menés par l'auteure, dans la recherche qu'elle développe sur le corps féminin, l'image, la souffrance psychique et la régulation sociale. La «laideur¼ ou l'«étrange¼ peut souvent être prise comme un message, dont la force réside précisément dans sa présentation surprenante. En ce sens, les pratiques corporelles peuvent être comprises dans un scénario d'indifférenciation, dans l'estantiation de la vie quotidienne, de soumission au discours de l'autre, mais aussi, comme contestation, comme problématisation du statut du corps dans la contemporanéité.

The associations between physical fitness and body fatness with blood lipid profile in Japanese children and adolescents / 体力科学

<p>The purpose of the present study was to examine the associations between physical fitness and body fatness with blood lipid profile in 231 Japanese children and adolescents (12.1 ± 1.5 years). The primary outcomes of the present study were a lipid risk score which was calculated by summing up z scores of three lipid items (triglycerides, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol). Physical fitness was assessed by using the Japanese standardised fitness test. For body fatness, a percentage of overweight was calculated with using age-, sex-, height-specific standardised body mass. For combined analysis (fitness × fatness), the participants were cross-tabulated into four groups (Non-Obese/Higher-Fit, Non-Obese/Lower-Fit, Obese/Higher-Fit, and Obese/Lower-Fit). The results demonstrated that the participants in fitness categories A/B [most fit] and C [middle] demonstrated the lower (better) lipid risk score than the participants in fitness categories D/E [least fit] (F _{(2, 222)} = 6.03, p = .003). For body fatness, the lipid risk score in obese group was significantly higher (worse) than that in thin and normal groups (F _{(2, 222)} = 6.08, p = .004). The combined analysis showed that there was a significant interaction (fitness × fatness) on the lipid risk score (F _{(1, 221)} = 4.05, p = .047), suggesting that Obese/Lower-Fit group had the worst risk score compared to the other groups. The present study suggests that improving both fitness and body fatness might be important for better lipid profile in Japanese children and adolescents.</p>

Association of Physical Activity and Body Fatness with Vitamin D Deficiency in Older Adults

BACKGROUND: This study investigated the association between physical activity and body fatness with serum vitamin D level in older adults. METHODS: A total of 233 older adults (39 men and 194 women) aged older than 65 years were voluntarily recruited from a local community. Physical activity was monitored using a uniaxial accelerometer. Body fatness was measured using a standardized protocol. Subjects were classified as sufficient (>30 ng/mL), insufficient (20-29 ng/mL), or deficient (<20 ng/mL) based on serum vitamin D level. Pearson correlation analyses were used to calculate bivariate correlations between variables. Logistic regression was used to determine the odds ratio of serum vitamin D inadequacy. RESULTS: There were linear increases in physical activity parameters including daily steps (P<0.001), low-intensity physical activity (P<0.001), moderate-intensity physical activity (P<0.001), and high-intensity physical activity (P<0.001) and linear decreases in body fatness parameters such as body mass index (P=0.039) and waist circumference (P=0.020) across incremental vitamin D levels. Vitamin D level was positively associated with daily steps (P<0.001), low-intensity physical activity (P<0.001), moderate-intensity physical activity (P<0.001), and high-intensity physical activity (P<0.001) and negatively associated with body mass index (P=0.001), percentage body fat (P=0.005), and waist circumference (P=0.003). Compared to the active group (reference), the inactive group (P=0.001) had a significantly higher odd ratio for serum vitamin D deficiency even after adjusting for age and sex (P=0.002). CONCLUSION: The findings of this study suggest that physical activity and vitamin D supplementation should be promoted for healthy aging.

Life style Factors Influencing BMI of Females In Ha’il Region.

Background: Published health promoting or health risk behaviors data in a young population is sparse for Saudi Arabia. Identifying health risk factors early in life and promoting primary prevention interventions among the youth is of utmost importance to move in a healthier direction Objectives: The aim of this study is to identify the socio-economic factors influencing BMI in female students in University of Hail. Methodology: A cross sectional survey was carried out to evaluate dietary behaviors in a random sample of 200 adolescent students, from UOH female campus during the winter semester. Self administered questionnaire for dietary behaviors was used for survey by following anonymity and privacy. Results: This study was conducted to measure BMI and determine the socioeconomic factors affecting the relative weight of young adult females living in the city of Ha’il, Saudi Arabia. A total of 200 female subjects (mean ± SD: age: 19.76 ± 1.98 years and BMI: 23.47 ± 5.58 kg/m2) participated in the present survey. 28.5 % percent of study sample were either overweight or obese. Age wise distribution indicates overweight and obesity significantly increases with age. Breakfast is frequently skipped in overweight and obese subjects while frequency of snacking less among them. Findings of the current study also suggest habit of frequent snacking behavior inverse association with BMI. The current study findings have indicated no clear impact of physical activity on obesity prevalence.

Sobre uma falta que o excesso não cobre: reflexões clínicas acerca de uma jovem obesa e suas relações familiares / A lack that no excess can cover: clinical reflexion on the treatment of a young obese and her family relationships

A partir da década de 80 o corpo passou a ser tema da moda, objeto de preocupação dos estudiosos e fonte de angústia para as mulheres. Em uma sociedade onde o corpo, além de objeto de consumo, passa a ser lócus privilegiado da construção identitária feminina, a relação com o próprio corpo acaba por tornar-se desprazerosa e persecutória. Tomando a gordura como um paradigma da feiúra, o caso clínico apresentado busca explicitar como as atitudes em relação à gordura agenciam subjetividades e produzem vínculos sociais até então não evidenciados, tais como a profunda exclusão social vivida pelos indivíduos obesos. Tal alijamento social provoca um profundo sofrimento psíquico freqüentemente observado na clínica com obesos.Tomando como referência a teoria psicanalítica bem como sua leitura da dinâmica familiar buscamos entender a obesidade também como um sintoma que além de buscar enunciar o que não pode ser dito aponta claramente algumas disfunções familiares.

From the eighties on the body culture started to become a fashion theme, object of specialists' concern and anguish source for the women. In a society where the body, besides a consumption object, becomes the privileged locus of the feminine identity, the relationship with one's own body becomes unpleasant and persecutory. Taking fatness as a paradigm of ugliness, a clinical case is presented in order to point out how attitudes in relation to fatness produces subjectivities as well as specific social bonds marked by social exclusion. This social rejection provokes a deep psychic suffering frequently observed at the clinic with obese people. Taking as reference the psychoanalytic theory as well as its reading of the family dynamics we intend to understand the obesity also as a symptom that apart from looking for an enunciation of what cannot be said, points out to some of the family's dysfunctions.

Mapping of quantitative trait loci and confirmation of the FAT1 region on chromosome 4 in an F2 population of pigs

The objective was to map QTL on porcine chromosome 4 and to associate them with carcass and internal organ traits in an F2 population. The F1 population was produced by outbreed crossing, using two native Brazilian breed Piau boars and 18 commercial sows. A total of 617 F2 animals issued from 11 F1 boars and 54 F1 sows were typed for a total of five microsatellite markers. The data were analyzed by multiple regressions developed for the analysis of crosses between outbred lines, using the QTL Express software. Significant evidence for QTL was found for pig chromosome 4 regarding carcass and internal organ traits. All QTL were detected in the same region of the chromosome, designated FAT1.

The changes of body mass index and abdominal fatness in postpartum period / 대한산부인과학회지

OBJECTIVE: To investigate the changes of body mass index (BMI) and abdominal fatness of women in postpartum period, and to evaluate the relationship between two factors. METHODS: Sixty uncomplicated postpartum women were included. BMI and abdominal fatness using bioelectric impedance method were measured three times; at postpartum one day, one week, and six weeks. RESULTS: Mean BMI was 25.9+/-3.9 kg/m2, 24.8+/-3.8 kg/m2, 23.5+/-3.8 kg/m2, and abdominal fatness was 0.843+/-0.058, 0.850+/-0.054, 0.849+/-0.056 at postpartum one day, one week, and six weeks, respectively. The incidence of overweight women (BMI 23-24.9 kg/m2) was 35%, 25%, 20%, and the incidence of obesity women (BMI> or =25 kg/m2) was 45%, 38.3%, 26.7%, and the incidence of android obesity (abdominal fatness>0.85) was 43.3%, 43.3%, 38.3% at each three postpartum period. The cut-off values of BMI to predict android obesity was >24.9 kg/m2, >23.2 kg/m2, and >22.6 kg/m2 at postpartum one day, one week, and six weeks, respectively. CONCLUSION: The changes of postpartum body weight must be explored with abdominal fatness as well as BMI, and standard references for each postpartum periods are needed.

Investigation on Epidemiology and Relativity between TCM Types and Influencing Factors to Hypertension Fatness in Zhejiang province / 浙江中医药大学学报

[objective]Get to know something about middle-aged and senile hypertension fat people in Zhejiang province,analyse the relativity between TCM types and factors influencing hypertension fatness(HF),offer foundation to the prevention and treatment of HF with TCM. [Method]Take hypertension people over 40 years old as subjects in some communities of urban districts of Hangzhou city,Shaoxing city,Quzhou city and Wenzhou city in Zhejiang province;by filling in the table of“investigation table on epidemiology of community hypertension”,study the disease characteristics,distribution of TCM types of hypertensive fatness and the relativity between factors influencing hypertensive fatness and TCM types.[Result](1)In 3795 hypertension patients investigated,1444 are of hypertensive fatness,occupying 36.33%;among which,785 are overweighted,659 fat,798 central fat,646 peripheral fat,632 class I hypertension,559 class Ⅱ,253 class Ⅲ.(2)On TCM types,most are of accumulation of sputum wetness,occupying 50.07%,25.00%,13.99% and 11.94% for Yin deficiency and overwhelming Yang,deficiency of Yin and Yang and overwhelming liver fire respectively.(3)There’s relationship between ages,education,blood pressure classes and TCM types(P

Dietary Behaviors and Status of Nutrient Intakes by the Obesity Levels of Housewives in Daegu / 대한지역사회영양학회지

This study was intended to collect the baseline information on dietary behavior of adults to develop nutrition education program in the context of healthy weights at community level. Nutrient intakes of 128 housewives were assessed by 24 hour recall method. Also food habits, nutrition knowledge and attitude were investigated by self-administered questionnaires. Subjects were divided to under-weight, normal-weight, over-weight groups by body mass index (BMI). Most under-weight groups evaluated as their current body images were normal. 41% of normal-weight groups judged as their current body images were obese. Energy and fat intakes of over-weight group were significantly higher than that of under-weight and normal weight groups (p < 0.05). However, carbohydrate and protein intakes showed no significant differences among the three groups. It appeared that active attitude toward change in nutrition attitude of normalweight group was significantly higher than that of under-weight group (p < 0.05). There were no significant differences of food habit score, nutrition knowledge, and obesity habit scores among the three groups. The frequency of eating-out showed significant difference among three groups (p < 0.05). Food habit scores were positively related to health-concerned attitude (r = 0.174), convenience-concerned attitude (r = 0.229) and food enjoyed attitude (0.213) and negatively related to obesity habit score (r = -0.206). Also, positive correlation of body fat mass with frequency of eatingout (r = 0.213), instant food (r = 0.227) and amount of meal (r = 0.187) existed (p < 0.05). We concluded that nutrition education programs for housewives should include specific strategies to modify unsound food behaviors and inappropriate perception of body image for a healthy weight.

Dynamics of Body Mass Index and Abdominal Fatness in Postpartum Period / 대한산부인과학회지

OBJECTIVE: To investigate the dynamics of body mass index (BMI) and abdominal fatness of women in postpartum period, and to find cut-off values of BMI to predict android obesity. METHODS: Forty-three uncomplicated postpartum women were included. BMI and abdominal fatness using bioelectric impedance method were measured three times; at postpartum one day, one week, and six weeks. RESULTS: BMI was 24.9 +/- 2.6, 24.1 +/- 2.4, 23.0 +/- 2.4, and abdominal fatness was 0.842 +/- 0.035, 0.845 +/- 0.039, 0.839 +/- 0.036 at postpartum one day, one week, and six weeks, respectively. The incidence of overweight women (BMI 25-29.9) was 46.5%, 34.9%, 25.6%, and the incidence of android obesity (abdominal fatness>0.85) was 37.2%, 32.6%, 30.2% at each three postpartum period. The cut-off values of BMI to predict android obesity was >25.3, >23.6, and >22.9 at postpartum one day, one week, and six weeks, respectively. CONCLUSION: The dynamics of postpartum body weight must be explored with abdominal fatness as well as BMI. Further prospective long-term follow-up studies in a larger scale will be warranted to confirm these findings.

Negative Physical Self of Female Students from 12 to 22 Year-Old / 中国心理卫生杂志

Objective: To investigate the influence of social comparison and social support on negative physical self of female from adolescents to young adulthood. Methods: 980 female students aged from 12 to 22 completed NPSS-F (negative physical self scale-fatness), MSPSS (multidimensional scale of perceived social support) and PACS (physical appearance comparison scale). Their body mass index (BMI) was also calculated by weight and height of the subjects. Results: High school students had higher score in Fatness dimension than middle school students (13.5?9.3/11.0?9.0,P