ABSTRACT
Objective:To research the therapeutic effect dnd pulmonary ground substance rebuilding in the treatment on IPF patients by Feixian-Fang and.Methods:Treatment 20 cases IPF by Feixian Fang RCT prednisone three months.obsive The therapeutic efficacy and the levels of matrix met alloproteinase 1,2,tissue inhibtor of met alloproteinase(TIMP-1,2).Results: The total effective rate of Feixian-Fang group is 84.2%.The total effective rate of prednisone group is 81.3%.Feixian-Fang can reduce the level of MMP-1,MMP-2,TIMP-1,TIMP-2 in the serum.Concluds:Feixian-Fang can treat IPF probably through inhibiting pulmonary ground substance rebuilding.
ABSTRACT
Objective: To observe the effect of FeixianFang on matrix rebuilding of pulmonary fibrosis in rats.Methods: Rats were randomly divided into the model group,the sham operation group,the FeixianFang group and the prednisone group.Pulmonary fibrosis model was set up by intratracheal injection of bleocin.On the 14th,28th and 45th day,MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum were detected.Results: FeixianFang can significantly reduce the level of MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum of rats with pulmonary fibrosis.Conculusion: FeixianFang can inhibit matrix rebuilding in pulmonary fibrosis rats.