ABSTRACT
Objective To use the liquid phase coprecipitation method for preparing gemcitabine magnetic nanoparticles to the pouch,and explore the preparation process in a number of conditions. Methods The effect of different stirring speeds,Fe3+/Fe2+ratio,pH,temperature of Fe3O4 powder and emulsification condition,ultrasonic time,curing temperature on the preparation of target?ed magnetic nanoparticles were observed. Results The preparation of Fe3O4 nanoparticles was as follows:800 r/ min of stirring speed,1.7∶1 Fe3+/Fe2+ratio,pH=9,the reaction temperature of 60℃,and the 5∶40 water/oil compared,ultrasonic time of 10 min, 100℃curing temperature. Conclusion Fe3O4 powder with small particle size,high purity,and no agglomeration are prepared,the stability of the gemcitabine magnetic nanoparticles capsule is good.
ABSTRACT
Objective: To use the liquid phase coprecipitation method for preparing gemcitabine magnetic nanoparticles to the pouch, and explore the preparation process in a number of conditions. Methods: The effect of different stirring speeds, Fe3+/ Fe2+ ratio, pH, temperature of Fe3O4 powder and emulsification condition, ultrasonic time, curing temperature on the preparation of targeted magnetic nanoparticles were observed. Results: The preparation of Fe3O4 nanoparticles was as follows: 800 r / min of stirring speed, 1.7: 1 Fe3+/Fe2+ ratio, pH=9, the reaction temperature of 60 °C, and the 5: 40 water / oil compared, ultrasonic time of 10 min, 100 °C curing temperature. Conclusion: Fe3O4 powder with small particle size, high purity, and no agglomeration are prepared, the stability of the gemcitabine magnetic nanoparticles capsule is good.