ABSTRACT
Eosinophilic granuloma is a common hypersensitive inflammatory skin disease in cats, and rare in dogs and horses. The skin biopsies of 5 years old female Cocker spaniel and 2 years old female mixed dog had the clinical signs of skin nodules with alopecia were submitted for diagnosis. Solitary skin nodules and papillary nodules were presented on the left external ear and back of Cocker spaniel and on the external ear of mixed dog, respectively. Histopathologically, epidermis of skin showed mild to severe hyperplasia with multifocal ulceration. Small to large irregular, brightly eosinophilic foci with degenerating eosinophils and homogeneous degenerated collagens were existed in the dermis of both ear and back skin. Typical 'flame figures', a mixture of degenerated collagen and degranulated eosinophils, were observed in both cases. Based on the histopathologic findings and special staining characters, 2 cases were diagnosed as canine eosinophilic granuloma. This is the first report for the eosinophilic granuloma of dogs in Korea.
Subject(s)
Animals , Cats , Dogs , Female , Humans , Alopecia , Biopsy , Collagen , Dermis , Ear , Ear, External , Eosinophilic Granuloma , Eosinophils , Epidermis , Horses , Hyperplasia , Korea , Skin , Skin Diseases , UlcerABSTRACT
Wells' syndrome was first described by Wells in 1971 as a recurrent granulomatous dermatitis with eosinophilia and was later named eosinophilic cellulitis. It is defined by the following criteria: sudden onset of annular or circinate erythematous-edematous patches that rapidly evolve to morphea-like blue-slate-colored plaques; a histological feature characterized usually by the presence of 'flame figures'; non-constant blood hypereosinophilia. We present clinical and histopathologic features of three cases of eosinophilic cellulitis.
Subject(s)
Cellulitis , Dermatitis , Eosinophilia , EosinophilsABSTRACT
Wells' syndrome, or eosinophilic cellulitis, is characterized clinically by an acute dermatitis resembling cellulitis, which evolves into violaceous plaques that resolve spontaneously without scarring. The histopathologic features show dermal eosinophil infiltration and development of characteristic `flame figure'. Wells' syndrome has been described mainly in adults, and less than 20 childhood cases have been reported. We herein report a case of Wells' syndrome in a 3-year-old boy.
Subject(s)
Adult , Child , Child, Preschool , Humans , Male , Cellulitis , Cicatrix , Dermatitis , EosinophilsABSTRACT
Wells syndrome is a distinct,ive dermatosis clinically resemblin, acute cellulitis with sudden onset and spontaneous resolution after weeks or months without residue. Recurrences over many years are common. I report a case of Wells syndrome in a 38-year-old women whc had developed pruritic erythematous plaque on the left lower abdomen since a few moriths ago. The blood eosinophil count, was 6,900/mm and a biopsy specimen taken from an erythematous plaque showed diffuse tissue eosinophilia and many flame figures in the lower dermis and subcutaneous fat tissue.
Subject(s)
Adult , Female , Humans , Abdomen , Biopsy , Cellulitis , Dermis , Eosinophilia , Eosinophils , Recurrence , Skin Diseases , Subcutaneous FatABSTRACT
Eosinophilic cellutitis occurred in an otherwise healthy 38-year-old woman. The patient had 4 months history of extremely pruritic erythematous wheal-like lesions on the extremities with blood eosinophilia. The individual lesions persisted for up to 12 weeks and responded well to systemic corticosteroid therapy. Elistopathologically the lesion showed diffuse tissue eosinophilia, histiocytic granuloma and characteristic flame figures in the dermis.