ABSTRACT
Response gene to complement 32 (RGC-32) as an important response gene to complement was widely expressed in a lot of tissues and organs and participated in many biological processes such as cell proliferation and differentiation,cell cycle regulation,inflammation,immune regulation,and tumor,etc.As a cell cycle regulator,RGC-32 affected the development of numerous diseases by regulating the cell cycle.In recent years,many studies have shown that RGC-32 may be involved in the renal tubular injury and repair,and its role in the renal tubular injury and repair may be related to its regulation of cell cycle especially the G2/M.This article will make a brief review on the progress of the mechanism of RGC-32 regulating the renal injury and repair.
ABSTRACT
Response gene to complement 32(RGC-32)as an important response gene to complement was widely expressed in a lot of tissues and organs and participated in many biological processes such as cell proliferation and differentiation, cell cycle regulation, inflammation, immune regulation, and tumor, etc.As a cell cycle regulator, RGC-32 affected the development of numerous diseases by regulating the cell cycle.In recent years, many studies have shown that RGC-32 may be involved in the renal tubular injury and repair, and its role in the renal tubular injury and repair may be related to its regulation of cell cycle especially the G2/M.This article will make a brief review on the progress of the mechanism of RGC-32 regulating the renal injury and repair.
ABSTRACT
As one of the important response gene to complement,response gene to complement-32 (RGC-32) simultaneously involves in many other biological functions.Recent studies have shown that RGC-32 was one of the critical regulatory factors at the G2/M check point in the cell cycles and involved in the cell cycle regulation.The expression products of RGC-32 gene play the key roles in cell proliferation,differentiation,inflammation,tumor metastasis and other processes.However,it has not been clarified in its biological mechanisms of regulation in cell cycle.This article takes a brief review about RGC-32 on its gene structure,biological functions,regulation of cell cycle,and the relationship of cell cycle regulation which involves in RGC-32.