GABAA Receptors in Neuropsychiatric Disorders and Its Therapeutic Potential / 世界科学技术-中医药现代化

Abundant evidences indicate a role of GABAergic system in the pathogenesis of neuropsychiatric dis-orders. GABAA receptors modulators have been long used in clinical. But the unwanted side-effect and risk of drug dependence have limited their use. With the increase understanding of the role of individual GABAA recep-tor subtypes in the pathology of these diseases, the subtype-selective GABAA receptors modulators and the multi-compound therapy may serve as potential therapeutic strategies. Here we review the researches which revealed the involvement of GABAA receptors in anxiety, depression and schizophrenia, and the research for new development in subtype-selective GABAA receptor modulators.