ABSTRACT
【Objective】To observe the effect of Gastritis Prescription Ⅰ(GPⅠ) on the ultrastructure of gastric mucosa in spleen-deficiency atrophic gastritis(AG) patients.【Methods】Thirty chronic AG patients were treated with GPⅠ(mainly composed of Radix Codonopsis,Poria,Rhizoma Atractylodis Macrocephalae,Pericarpium Citri Reticulatae,Rhizoma Pinelliae,Fructus Amomi,Radix Angelicae Sinensis,Herba Taraxaci,Radix Paeoniae Alba,Radix Glycyrrhizae Preparata,etc.).The histological features of gastric mucosa sampled under gastroscope were observed before and after treatment under light microscope and electron microscope.【Results】After treatment,43.3% of moderate-degree and above atrophic area of gastric glands disappeared,and 16.7% became mild;36.7% of the disappeared gastric groove recurred and the thin gastric mucosa became normal.Microvilli of gastric gland became normal in 12 patients,accounting 54.5% in 22 patients with intestinal metaplasia.【Conclusion】GPⅠis effective in recovering the gastric mucosa of AG patients with deficiency of spleen and stomach Qi,and has an effect in counteracting intestinal metaplasia.
ABSTRACT
【Objective】To comprehensively evaluate the therapeutic effect of Professor Yu's spleen-strengthening,stomach-regulating and blood-activating therapy for chronic atrophic gastritis(CAG).【Methods】Thirty-two CAG patients collected in recent 3 years were treated with Weiwei Fuyuan Decoction(WFD),a prescription embodying Professor Yu's spleen-strengthening,stomach-regulating and blood-activating therapy.WFD is mainly composed of Radix Astragali,Radix Pseudostellariae,Radix Rehmanniae,Radix Notoginseng,Faeces Trogopterori,Herba Scutellariae Barbatae,Herba Hedyotis Diffusae,Fructus Aurantii Immaturus,Rhizoma Corydalis,etc..CAG was classified into mild,moderate and severe degree in this study.The treatment lasted 3 months to half a year.After treatment,the effect of WFD on clinical symptoms,gastroscope,pathological changes,helicobacter pyloria(HP)infection was observed and compared to that before treatment.【Results】After treatment,the clinical symptoms were much relieved,and atrophy of gastric mucosa(GM)under gastroscope was also relieved(P