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ChatGPT is a large language models(LLMs)that uses deep learning techniques to produce human-like responses to natural language inputs. It belongs to the family of generative pre-training transformer(GPT)models currently publicly available developed by OpenAI in November 2022. ChatGPT is capable of capturing the nuances and intricacies of human language, generating appropriate and contextually relevant responses. It can assist medical professionals in various tasks, such as research, diagnosis, patient monitoring, and medical education, from identifying research programs to assisting in clinical and laboratory diagnosis, to know new developments in their fields and scientific writing. ChatGPT has also attracted increasing attention and widely used in ophthalmology. However, the use of ChatGPT and other artificial intelligence tools in such tasks comes now with several limitations, ethical and legal concerns, such as credibility, plagiarism, copyright infringement, and biases. Future research can focus on developing new methods to mitigate these limitations while harnessing the benefits of ChatGPT in medicine and related aspects.
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Esta cronología es una idea del psicoanalista e investigador francés Théo Lucciardi y fue publicada originalmente en el número 3 de la revista LAPSUS NUMÉRIQUE. Su autor ha preparado esta versión actualizada a 2023 especialmente para este número de Aesthethica. La secuencia, que va desde la invención de la rueda hasta la IA generativa, permite detenernos en los grandes hitos del desarrollo científico tecnológico y a la vez advertir ve el grado de aceleración de la última década. Se pueden reconocer allí varios de los temas que integran la agenda contemporánea en materia de bioética y que están presentes en este número de la revista. Algunos de ellos son cruciales para la lectura ético-analítica que proponemos, como la vigencia de la lógica booleana, la actualización del Test de Turing o el porvenir de la IA y el Chat GPT
This chronology is an initiative of the French psychoanalyst and researcher Théo Lucciardi and was originally published in number 3 of the LAPSUS NUMÉRIQUE magazine. Its author has prepared this updated version to 2023 especially for this issue of Aesthethica. The sequence, which goes from the invention of the wheel to generative AI, allows us to stop at the great milestones of technological scientific development and at the same time notice the degree of acceleration of the last decade. Several of the issues that make up the contemporary agenda in bioethics and that are present in this issue of the magazine can be recognized there. Some of them are crucial for the ethical-analytical reading that we propose, such as the validity of Boolean logic, the updating of the Turing Test or the future of AI and Chat GPT
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History, Ancient , History, 21st Century , Scientific Research and Technological Development , Artificial Intelligence , ChronologyABSTRACT
Introducción: Los avances de unas tecnologías y la obsolescencia de otras marchan a una velocidad inimaginable, especialmente en este siglo xxi. En los últimos meses de 2022 y primeros meses de 2023 muchas incógnitas y controversias en diferentes campos han surgido en torno a los Chat GPS, una innovación que presenta desafíos nunca pensados para la sociedad actual, así como nuevos retos que impactarán de manera directa en la formación y/o desempeño de profesores, estudiantes, profesionales de la salud, juristas, políticos, informáticos, bibliotecarios, científicos y cualquier ciudadano. Objetivo: Identificar algunas características del chat GPT y su posible impacto en el educación. Posicionamiento de los autores: Se leen en las noticias y reportajes valoraciones de especialistas; se han realizado encuentros virtuales y exposiciones; y están disponibles diversos artículos y videos sobre este tema, algunos llegan a ser elaborados con el propio asistente. Por la novedad del tema, la reciente incorporación como herramienta para el desarrollo profesional, así como por el interés mostrado en los últimos días por la comunidad de profesores de las ciencias médicas cubanas, y considerando que esta herramienta es resultado del desarrollo de la inteligencia artificial, cabe preguntarse: ¿en qué consiste? y ¿cuáles son sus perspectivas? Conclusiones: Resulta oportuno acercarse al tema desde las posibilidades y los retos que abre a la educación y el aprendizaje, en particular a la docencia médica(AU)
Introduction: The advances of some technologies and the obsolescence of others are marching at an unimaginable speed, especially in this twenty-first century. In the last months of 2022 and first months of 2023, many questions and controversies in different fields have arisen with respect to Chat GPT, an innovation that presents challenges never thought of before for today's society, as well as new challenges that will have a direct impact on the training and/or performance of professors, students, health professionals, law practitioners, politicians, computer scientists, librarians, scientists and any citizen. Objective: To identify some technological characteristics of Chat GPT. Positioning of the authors: In news and reports, assessments by specialists are read; virtual meetings and presentations have been held; and several articles and videos on this topic are available, some of them even elaborated by the assistant itself. Due to the novelty of the subject, its recent assimilation as a tool for professional development, as well as the interest shown in recent days by the community of professors of Cuban medical sciences and considering that this tool is the result of the development of artificial intelligence, it is worth wondering what it consists in and what its prospects are. Conclusions: It is appropriate to approach the subject with a focus on the possibilities and challenges that it opens to education and learning (AU)
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Humans , Teaching/education , Artificial Intelligence/history , Artificial Intelligence/trends , Education, Medical/methods , Education, Medical/trends , Machine Learning , Learning , Universities , Natural Language Processing , Nonverbal CommunicationABSTRACT
OBJECTIVE To evaluate the safety and suitability of traditional Chinese medicine prescriptions generated by generative artificial intelligence （AIGC）， and to provide research ideas for empowering the traditional Chinese medicine industry with AIGC. METHODS Using the 2020 edition of Chinese Pharmacopoeia and the 5th edition of Traditional Chinese Medicine as corpus， GPT-4 and the real-time networking model developed based on GPT-4 （referred to as the “networking model”） were used for deep learning. The clinical cases included in the consensus of traditional Chinese medicine experts in recent years were extracted manually to regenerate prescriptions based on diagnosis using the GPT-4 model and networking model； traditional Chinese medicine experts conducted blind evaluation and scoring of GPT-4 generated prescriptions， networking model generated prescriptions， and expert consensus prescriptions. At the same time， Turing testing was used to evaluate whether the GPT-4 model and networking model had the same ability as human intelligence. RESULTS The average score of traditional Chinese medicine prescriptions generated by the GPT-4 model showed no statistically significant difference compared to manual prescriptions （P＞0.05）， while the average score of prescriptions generated by the networking model showed no statistically significant difference compared to traditional Chinese medicine prescriptions generated by the GPT-4 model （P＞0.05）. The proportion of model-generated prescriptions mistakenly judged as manual prescriptions in the Turing test was 51.11%. CONCLUSIONS The traditional Chinese medicine prescriptions generated by the GPT-4 model have reached a certain level of safety and suitability， and the GPT-4 model has passed the Turing test. The introduction of AIGC in the diagnosis and treatment process may provide technical support for the rational use of clinical traditional Chinese medicine.
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RESUMEN La obesidad infantil va en aumento, relacionado a los malos hábitos alimentarios y el sedentarismo; puede desembocar en el desarrollo del síndrome metabólico, incrementando el riesgo de enfermedades crónicas, entre ellas, la esteatosis hepática. El objetivo de este estudio fue determinar la utilidad de la ecografía en la detección de esteatosis hepática en niños con sobrepeso u obesidad que concurrieron al Hospital Regional de Encarnación de marzo a junio de 2019. Se estudiaron a 50 niños de ambos sexos de 5 a 14 años con sobrepeso u obesidad, mediante examen clínico, antropometría, ecografía y marcadores bioquímicos. Se encontraron 18 pacientes (36%) con esteatosis hepática, mediante ecografía, predominando en varones, con obesidad severa de tipo visceral. La Acantosis nigricans, el perímetro abdominal por encima del percentil 90, GPT y triglicéridos séricos elevados, fueron los hallazgos más relevantes asociados a esteatosis hepática. La ecografía simple en modo B, resultó ser un método útil para la detección de esteatosis hepática en niños obesos, asociado a la presencia de perímetro abdominal por encima del percentil 90, Acantosis Nigricans, GPT y triglicéridos elevados. Este esquema de manejo inicial sería muy útil y de fácil aplicación en la evaluación y control de esta afección que va en aumento en la población pediátrica.
ABSTRACT Childhood obesity is increasing, related to bad eating habits and sedentary lifestyle; It can lead to the development of metabolic syndrome, increasing the risk of chronic diseases, including liver steatosis. The objective of this study was to determine the usefulness of ultrasound in the detection of hepatic steatosis in overweight or obese children who attended the Regional Hospital of Encarnación from March to June 2019. Fifty children of both sexes from 5 to 14 years old were studied with overweight or obesity, through clinical examination, anthropometry, ultrasound and biochemical markers. 18 patients (36%) were found with hepatic steatosis, by ultrasound, predominantly in men, with severe obesity of visceral type. Acanthosis nigricans, the abdominal perimeter above the 90th percentile, GPT and elevated serum triglycerides, were the most relevant findings associated with hepatic steatosis. Simple B-mode ultrasound proved to be a useful method for the detection of hepatic steatosis in obese children, associated with the presence of abdominal perimeter above the 90th percentile, Acanthosis nigricans, GPT and elevated triglycerides. This initial management scheme would be very useful and easy to apply in the evaluation and control of this condition that is increasing in the pediatric population.
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Objective: To investigate the role and mechanism of glutamic-pyruvic transaminase 2 (GPT2) on cisplatin resistance in gastric cancer. Methods:The Kaplan Meier-Plotter database was used to analyze the relationship between GPT2 expression and poor prognosis of gastric cancer. The expressions of GPT2 in gastric cancer cells and tissues were detected by quantitative real-time PCR (qPCR), Western blotting and immunohistochemistry (IHC). The cytotoxicity of cisplatin at different concentrations to human gastric cancer cells and normal gastric epithelial cells was detected by CCK-8 assay. GPT2 overexpression and knockdown cell lines were constructed in cisplatin sensitive MKN28 cells and insensitive MKN45 cells, respectively. CCK-8 assay, colony formation assay and Western blotting were performed to evaluate the cellular cytotoxicity, stemness of cancer cells and the changes of key proteins in stemness-related signaling pathways in GPT2 overexpression and knockdown cell lines, respectively. Results:The high expression of GPT2 was negatively correlated with the survival of gastric cancer patients. Gastric cancer cells with high expression of GPT2 were resistant to cisplatin, while cells with low expression of GPT2 were sensitive to cisplatin. Overexpression of GPT2 could decrease the cell sensitivity to cisplatin, nevertheless knockdown of GPT2 could increase the cell sensitivity to cisplatin. Meanwhile, the further study revealed that overexpression of GPT2 could activate the extracellular regulated protein kinases (ERK) signaling pathway, up-regulate the expression of SRY-box 2 (SOX2) and Nanog homeobox (NANOG), and enhance the ability of colony formation, while knockdown of GPT2 could inhibit ERK signaling pathway, reduce the expression of SOX2 and NANOG, and suppress the ability of colony formation. Conclusion:GPT2 expression are related to the sensitivity of cisplatin treatment. Overexpression of GPT2 can increase the resistance of gastric cancer to cisplatin treatment by activating ERK signaling pathway and up-regulating the expression of SOX2 and NANOG.
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HCV genotypes have been documented in clinical practice. The aim of this study was to determine the replication priority of different HCV genotypes in a Chinese HCV positive cohort. Serum samples from 491 apparently healthy Chinese blood donors testing positive for HCV antibodies and naive to antiviral drug therapy were tested. Genotyping analysis showed that genotypes 1b and 2a were predominant and accounted for 77.6% of the HCV infections. Among the genotype groups, individuals infected with genotype 2a had an HCV RNA viral load (10(8) copies/mL) about 200-fold (lg, 2.3) greater than those infected with other genotypes (10(4)-10(5) copies/mL) indicating a replication priority of genotype 2a. However, there was no correlation between HCV genotype and antibody response suggesting that the amplification advantage of genotype 2a results from a favorable interaction with the host cellular environment. In conclusion, HCV genotypes 1b and 2a are the predominant genotypes in China and genotype 2a possesses a significant replication priority compared with the other genotypes. This suggests the existence of host cellular factors that may act as drug-targets for entirely clearing HCV infection in the future.
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El objetivo de este trabajo es determinar si las transaminasas hepáticas tienen valor como pruebas complementarias que orienten el diagnóstico de hepatitis B y C, en donantes de sangre con anticuerpos positivos por el método ELISA a estas infecciones virales; teniendo en cuenta que las pruebas confirmatorias como el inmunoensayo recombinante (RIBA) o la prueba de ácidos nucleicos por técnicas moleculares como PCR (RNA HCV) para hepatitis C y DNA viral (PCR) para hepatitis B no se realizan aún en nuestro país debido a sus elevados costos. Se busca sumar esfuerzos en salud pública desde los bancos de sangre debido a la trascendencia de llegar a un diagnóstico en los donantes seropositivos, que hayan sido captados en el tamizaje, para prevenir la propagación de estas hepatitis. Se realizaron pruebas serológicas para hepatitis C, anticuerpos frente al antígeno del core de la hepatitis B y determinaciones de los niveles de GPT o ALT (Transaminasa Glutámica Pirúvica o Alanina Amino Transferasa), GOT o AST (Transaminasa Glutámico Oxalacética o Aspartato Amino Transferasa) en 236 donantes de sangre seropositivos para hepatitis B y C del Banco de Sangre del Hospital de Clínicas de la Universidad Nacional de Asunción-Paraguay. Las transaminasas elevadas fueron clasificadas de acuerdo a los marcadores serológicos positivos para hepatitis B y C, encontrándose niveles elevados en un 13.9% de individuos con anti-HBc, 40% en individuos con anti HCV y 2 de 7 casos en individuos con serología positiva para ambos marcadores serológicos. Casi la mitad de los donantes con marcador serológico positivo para anti HCV presentan elevación de las transaminasas.
The aim of this study was to determine if liver transaminases had value as complementary tests to orientate the diagnosis of hepatitis B and C in blood donors with positive antibody to these viral infections by the EIA method, considering that confirmatory tests such as the recombinant immunoassay (RIBA) or nucleic acid test by molecular techniques such as PCR (HCV RNA) for hepatitis C and viral DNA (PCR) for hepatitis B are not performed in our country due to their high costs. We are looking for joining efforts in public health from the blood banks due to the importance of reaching a diagnosis of seropositive donors who have been detected in the screening to prevent the spread of hepatitises. Serologic tests for hepatitis C, antibodies against the core antigen of hepatitis B and determinations of the levels of ALT or GPT (Alanine aminotransferase or Glutamic pyruvic transaminase), AST or GOT (Aspartate aminotransferase or Glutamic oxalacetic transaminase) were carried out in 236 blood donors seropositive for hepatitis B and C of the Blood Bank of the Hospital de Clinicas, National University of Asuncion, Paraguay. Elevated transaminases were classified according to the positive serological markers for hepatitis B and C finding high levels in 13.9% in donors with anti-HBc, 40% in donors with anti HCV and two of seven cases in donors with positive serology for both serological markers. Almost half of the donors with positive serologic marker for anti HCV had elevated transaminases.
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Aspartate Aminotransferases , Blood Banks , Blood Donors , Hepatitis B Antibodies , Hepatitis C AntibodiesABSTRACT
Present study was conducted to investigate the effects of exercise and cholesterol diet on plasma and liver lipids, platelet aggregation, erythrocyte Na efflux and liver index such as GOT and GPT using Sprague Dawley rats. Forty rats were divided into four groups and fed control or 0.5% cholesterol diet with and without treadmill for six weeks. The final body weight of group fed cholesterol diet with exercise was somewhat decreased compared with group fed cholesterol diet without exercise. L.W/B.W ratio was significantly increased in groups fed cholesterol diet (p < 0.01), but exercise tended to decrease this ratio. Plasma total cholesterol was significantly increased and HDL-cholesterol was decreased in groups fed cholesterol diet (p < 0.01). Plasma triglyceride was significantly decreased in groups fed cholesterol diet compared with groups fed control diet (p < 0.01). Plasma triglyceride of groups with exercise was significantly decreased compared with their non exercising counterparts regardless diet (p < 0.05). Liver total cholesterol and triglyceride was significantly increased in groups fed cholesterol diet (p < 0.01), but exercise did not affect on these levels. Na-K ATPase was somewhat decreased in groups fed cholesterol diet, and exercise tended to recover the reduced Na-K ATPase. Na passive transport was significantly decreased in group fed control diet without exercise and significantly increased in group fed cholesterol diet with exercise, there were significant differences between groups (p < 0.05). There were no differences in total Na efflux and intracellular Na among groups, and total Na efflux was not correlated with intracellular Na. Hematocrit was significantly lower (p < 0.05) in group fed cholesterol diet without exercise compared with other groups. Platelet aggregation in the initial slope and the maximum was increased in groups fed cholesterol diet, but not statistically significant. Exercise especially increased the initial slope of aggregation. Plasma GOT and GPT was significantly increased in groups fed cholesterol diet (p < 0.01), and exercise in group fed cholesterol diet significantly decreased both GOT and GPT compared with the non exercising counterpart (p < 0.01). This study showed that cholesterol diet increases plasma and liver lipids and GOT and GPT, and exercise improves plasma and liver lipid profile and liver index of GOT and GPT preventing fatty liver.
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Animals , Rats , Adenosine Triphosphatases , Blood Platelets , Body Weight , Cholesterol , Diet , Erythrocytes , Fatty Liver , Hematocrit , Liver , Plasma , Platelet Aggregation , Rats, Sprague-DawleyABSTRACT
In order to elucidate the effects of a lacto-ovo vegetarian diet on serum lipid levels, 91 male collegians residing in the Seoul area were recruited. The vegetarians did not smoke tobacco nor drink alcohol. Their anthropometric measurements, dietary intakes, and blood lipid concentrations were compared to age-matched omnivorous controls. The subjects were divided into four groups. The four groups were: 1) NSNDV (n=25): Non Smoking Non Drinking Vegetarians, 2) NSNDO (n=10): Non Smoking Non Drinking Omnivores, 3) SDO (n=37): Smoking, Drinking Omnivores, 4) SDM (n=11): Smoking Drinking Meat-eaters. Total serum cholesterol, HDL-cholesterol and hematocrit were analyzed. The results were as follows: Weight (p<0.05) and BMI (p<0.01) were significantly higher in SDM than NSNDV. Dietary protein (p<0.01), iron (p<0.05) and dietary lipids (p<0.01) from animals in NSNDV were significantly lower than the results in the SDM. Interestingly enough, we noted no significant differences between the four groups in terms of average total dietary protein, dietary lipids and dietary iron, total serum cholesterol, or HDL-cholesterol. Dietary fiber intake was significantly higher in NSNDV than in SDM (p<0.05). Weight, BMI, and total cholesterol were significantly positively correlated with animal protein (p<0.05) and animal lipid (p<0.01) intake. These results showed that vegetarian collegians who haven't smoked tobacco nor drunk alcohol evidenced lower body weight, BMI, and dietary animal lipid intake, but higher dietary fiber intake, than the other three groups. Additionally, intake of animal protein (p<0.001) and intake of animal lipids (p<0.001) were significantly positively correlated with body weight, BMI, and total serum cholesterol in male collegians.
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Animals , Humans , Male , Aminoacridines , Body Weight , Cholesterol , Diet, Vegetarian , Dietary Fiber , Dietary Proteins , Drinking , Hematocrit , Iron , Iron, Dietary , Smoke , Smoking , NicotianaABSTRACT
This study was conducted to investigate the effect of different kinds of traditional Korean soybeans on blood and liver lipids and lipid peroxidation. SD male rats (n =48 )were assigned to six different groups and provided expe-rimental diets for 28 days. The protein source of the diet was casein, isolated soy protein (ISP ), or casein plus traditional soy powders (yellow bean, huktae, jinuni or seorietae ). The ISP, jinuni and seorietae diet decreased blood triglyceride compared to casein group. The ISP groups had lower hepatic total lipid and triglycerides than casein groups. The yellow bean and seorietae group had hepatic lipid lowering effects, but the effect was not found in huktae and jinuni group. The glutamate-oxaloacetate transaminase activity was significantly decreased in ISP and jinuni groups than in casein group. The glutamate-pyruvate transaminase activity was also decreased in ISP group. The results of this study suggest that jinuni, yellow bean and seorietae groups are more effective in lowering body lipids than huktae group.
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Animals , Humans , Male , Rats , Caseins , Diet , Lipid Peroxidation , Liver , Powders , Soybean Proteins , Glycine max , TriglyceridesABSTRACT
The preparation method of a soluble dietary fiber from oak wood (Quercus mongolica) and the effect of the soluble dietary fiber on physiological function in rat fed high cholesterol diets was investigated. The best condition for steam explosion method was 25 kgf/cm3 pressure for 6 min. The exploded samples were delignified by the filtration treatment with 1% NaOH for several times, which is the best condition. The enzymatic hydrolysis of Cellusoft cellulase was more effective than Onozuka R-10 cellulase. The manufactured soluble dietary fiber was assayed using gel permeation chromatography (GPC) and it was dissolved in water. Average molecular weight distribution of manufactured soluble dietary fiber was about 348-1,200 and it was assumed the oligomer form fraction. In order to compare the manufactured soluble dietary fiber with commercial soluble dietary fiber (pectin) on the physiological function, Sprague-Dawley male rats weighing 100+/-10 g were randomly assigned to one normal diet and five high cholesterol diet containing 1% cholesterol. The high cholesterol diet groups were classified to fiber free diet (FF group), 5% pectin (5P group), 10% pectin (l0P group), 5% manufactured soluble dietary fiber (5M group) and 10% manufactured soluble dietary fiber (10M group). Body weight gains in all soluble dietary fiber groups were lower than FF group. Food intakes were increased in all soluble dietary fiber groups than that of FF group. Food efficiency ratio (FER) was significantly decreased in all soluble dietary fiber groups than that of the FF group, and it was especially was highest in 10% supplemented soluble dietary fiber group. The weight of liver of the soluble dietary fiber supplemented groups were lower than those of the FF group, but weights of cecum and small intestine of all supplemented soluble dietary fiber groups were significantly increased, compared with that of FF group. The weights and water contents in feces were significantly increased by the soluble dietary fiber. The activity of the glutamic oxaloacetic transaminase in soluble dietary fiber groups were significantly decreased than those of FF group. The hepatic glutathione S-transferase activity in all soluble dietary fiber supplemented groups were higher than that of FF group. The physiological effects of the manufactured soluble dietary fiber are the same as the commercial soluble dietary fiber (pectin). The preparation method of the soluble dietary fiber from the oak chips suited to its purpose.
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Animals , Humans , Male , Rats , Aspartate Aminotransferases , Body Weight , Cecum , Cellulase , Cholesterol , Chromatography, Gel , Diet , Dietary Fiber , Explosions , Feces , Filtration , Glutathione Transferase , Hydrolysis , Intestine, Small , Liver , Molecular Weight , Rats, Sprague-Dawley , Steam , Water , Weights and Measures , WoodABSTRACT
AIM: The synthesis of sarmentosin. METHODS: Condensation of butane-1,2,4-triol-1,2-acetonide(3) with α-D-glucopyranosyl bromide tetraacetate in the presence of Ag2O and molecular sieves gave the desired β-glucoside 4,which was transformed into sarmentosin via a reaction sequence of 7 steps. RESULTS: The overall yield is 5.8%. CONCLUSION: The first synthesis of sarmentosin(1),a potent natural GPT lowering agent,was achieved.
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This study was carried out to discover the effects of eating habits and health-related life style on blood pressure, gamma-Glutamic acid Peptide Transferase(gamma-GPT), blood glucose and High Density Lipoprotein-Cholesterol(HDL-C). 185 subjects(85 male, 100 female) were selected, who were living in the Cheonju area aged 40's to 60's. The mean systollic blood pressure(SBP), diastollic blood pressure (DBP), gamma-GPT, fasting blood sugar(FBS) and HDL-C for all the subjects were 118 mmHg, 77 mmHg, 281U/l, 90 mg/dl and 45 mg/dl, respectively. The SBP and DBP for subuects over 60 years old were 126 mmHg and 81 mmHg and were significantly higher than subjects in their 40's and 50's(p<0.001, p<0.005). The HDL-C of the group that rarely ate breakfast was 57 mg/dl and that was significantly higher than the 44 mg/dl scored by those who ate breakfast everyday(p<0.05). The SBP for subjects having a snack 2-3 times/week was 125 mmHg and that was significantly higher than the 114 mmHg of those having a snack everyday(p<0.05). The gamma-GPT for subjects consuming alcohol everyday was 44IU/L and that was significantly higher than 18IU/I of the non-drinking group(p<0.001). The gamma-GPT of light smokers was 53IU/I and that was significantly higher than the 22IU/I for non-smoking participants(p<0.001). The DBP, SBP, gamma-GPT, FBS and HDL-C related to exercise not significantly different. The SBP(p<0.001) and DBP(p-0.01) between age group was positively correlated. The gamma-GPT between drinking frequency(p<0.001), drinking quantity(p<0.05), and smoking(p-0.05) was also positively correlated. The FBS between exercises had a negative correlation(p<0.05), and the HDL-C between breakfast had a negative correlation(p<0.05). These results indicate that decreasing drinking and smoking, when combined with appropriate exercise, will decrease the gamma-GPT and fasting blood sugar level, and help preventing adult diseases.
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Adult , Humans , Male , Middle Aged , Blood Glucose , Blood Pressure , Breakfast , Drinking , Eating , Exercise , Fasting , Life Style , Smoke , Smoking , SnacksABSTRACT
The purpose of this study is to make clear a comprehensive relationship between serum transaminase activity and food intake pattern. A total of 146 young male student participated in the study.<BR>The results of the survey were as follows:<BR>1) The first factor (Fl) was a“animal-related food factor”. The second factor (F2) was considered to be a“rice versus noodles factor”. The third (F3), fourth (F4), fifth (F5) and sixth (F6) factor could not be explained simply in terms of their factor.<BR>2) Significantly negative correlations were observed between SGOT and the factor scores of Fl (r=-0.256, p<0.01), SGPT and the factor scores of Fl (r=-0.243, p<0.01), and SGPT and factor scores of F2 (r=-0.195, p<0.05), but not between SGOT or SGPT and other factors.
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The protective effect of TGPs on acute liver damage induced by carbon tetrachloride ( CCl4 ) was investigated in mice . TGPs ( 40 or 80mg/kg?d ? 3d, ip ) reduced the elevation of plasma or serume gl- utamic pyruvic transaminase ( GPT ) and plasma lactate dehydroge-nase ( LDH ) in CCl4-intoxicated mice, but if had no significant influence on the elevation of plasma glutamic oxalacetic transaminase ( GOT).TGPs (40mg/kg?d ? 3d, ip ) showed a protective effect on the histopathologic changes of liver injury induced by CCl4. The results suggest that TGPs may a protect against hepatic damage.
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Objective To establish a new allele specific PCR method for GPT typing: and study GPT polymorphism by FLDAS-PCR and PCR-RFLP. Method 248 unrelated individuals of Han were genotyped using FLDAS-PCR and PCR-RFLP. Results Three genotypes were identified with DP of 0.631 in Han population. Typing results by FLDAS-PCR were completely consistent with those by PCR-RFLP. The allele frequencies were GPT * 1 = 0.5423 and GPT * 2 = 0.4577. The population data fitted the Hardy-Weinberg law. Conclusion GPT-FLDAS-PCR and GPT-RFLP method is useful for forensic identification.
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Chronic hepatic injury animal model induced by TEF was made with carbontetrachloride, ethyl alcohol and a high-fat feed. An increase in serum GPT, LDH_5 and r-globulin, a decrease in serum albumin and a remarkable increase in hepatic collagen were found. The results indicated that all biochemical data obtained in this model is similar to those in patients with chronic active hepatitis.
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To evaluate the effect of vitamin E on GPT, GOT and LDH activity of cold exposed rats, young male rats (70-100g body weight) were randomly divided into Ⅰ-Ⅲ groups. All the animals were fed on basic ration. The group I was given vitamin E 5mg (5mg/ml) intraperitoneally once every other day for 10 days. After the vitamin E treatment, group Ⅰ and Ⅲ were kept in a cold chamber (-1?1℃) and group Ⅱ at room temperature (20?1℃) for 48 hours. At the end of experimental period, serum GPT, GOT and LDH activity of all animals were analyzed. According to the data, the GPT, GOT and LDH activity were increased significantly in group I than in groups Ⅰ and Ⅱ. These results suggested that the vitamin E may have the efficiency of maintaining the structural integrity of the cells of cold exposed animals.