ABSTRACT
Objective: In patients with acute coronary artery disease, the TIMI risk index (TRI), the thrombolysis in myocardial infarction (TIMI) risk score, and the global registry of acute coronary events (GRACE) risk score (GRS) have all been documented. The aim of this study was to determine the relationship between no-reflow (NRF) and admission TRI, major cardiac events (MACE), and in-hospital mortality in patients undergoing primary percutaneous coronary intervention (P-PCI). Methods: Between March and December 2019, 100 consecutive patients diagnosed with STEMI and treated with PPCI at Tanta Main University Hospital in Tanta, Egypt, were included in the research population. Each patient consented following a thorough history taking, evaluation of coronary risk factors, clinical examination, and electrocardiogram analysis. Additionally, all instances were classified using the Killip method. The GRS, TRS, and TRI values were examined. Results: The GRS, TRS, and TRI scores were significantly associated with increased NRF, MACE, and hospital mortality in STEMI patients treated with P-PCI, suggesting that TRI is a straightforward indicator with fewer parameters that accurately reflects P-PCI success. Conclusion: TRI has been demonstrated to enhance the risk of in-hospital mortality and MACE. TRI uses straightforward and cost-effective ways to test patients who have experienced a STEMI. Additionally, a high TRI may assist in identifying high-risk individuals and developing suitable treatment solutions.
ABSTRACT
O presente estudo buscou analisar as evidências de validade de conteúdo da versão brasileira da Gifted Rating Scales (GRS). Após tradução e adaptação dos itens, seis estudantes de pós-graduação atuaram como juízes, classificando os 72 itens que compõem o instrumento em seis subfatores (habilidade acadêmica, habilidade intelectual, criatividade, liderança, motivação e talento acadêmico). Os resultados demonstraram que a maior parte dos itens (n=54) foi classificada adequadamente pelos juízes, alcançando índices de concordância acima de 80 por cento. Cinco itens apresentaram problemas mais graves e devem ser reformulados. As análises dos coeficientes Kappa permitiram concluir que parece ser mais fácil para os juízes identificarem os itens pertencentes à área de motivação, sendo a área da capacidade acadêmica mais difícil. De uma forma geral, os resultados apontaram a adequação da versão brasileira aos conteúdos do modelo que ela pretende avaliar. Estudos futuros serão conduzidos com a finalidade de verificar se os mesmos fatores são mantidos na amostra brasileira.
This study investigates the evidence of content validity of the Brazilian version of the Gifted Rating Scales (GRS). After translated and adaptation of items, six post-graduate students acted as judges rating the 72 items that composing the instrument in six sub-factors (intellectual ability, academic ability, creativity, leadership, motivation and artistic talent). The results showed that most items (n=54) were properly classified by the judges, achieving concordance rates above 80 percent. Five items had more serious problems and should be reworked. The analysis of Kappas coefficient showed that seem to be easier for judges to identify the items belonging to the area of motivation, being the area of academic ability more difficult. In general the results confirmed the adequacy of the Brazilian version of the content model that its wants to assess. Futures studies will be conducted in order to examine whether these factors are held in the Brazilian population.
El presente estudio busca evidencias de validez de contenido de la versión brasileña de la Gifted Rating Scale (GRS). Tras la traducción y adaptación de los ítems, seis estudiantes de posgrado actuaron como jueces, clasificando los 72 ítems que componen el instrumento en seis subfactores (habilidad académica, habilidad intelectual, creatividad, liderazgo, motivación y talento académico). Los resultados demostraron que la mayor parte de los ítems (n=54) fue clasificada adecuadamente por los jueces, alcanzando índices de concordancia por encima de 80 por ciento. Cinco ítems presentaron problemas más graves y deben ser reformulados. Los análisis de los coeficientes Kappa permitieron concluir que parece ser más fácil para los jueces identificaren los ítems pertenecientes al área de motivación, siendo los de capacidad académica más difíciles. En general, los resultados demostraron la adecuación de la versión brasileña a los contenidos del modelo que ella pretende evaluar. Estudios futuros serán conducidos logrando verificar si los mismos factores son mantenidos en la muestra brasileña.
Subject(s)
Humans , Male , Female , Aptitude , Intelligence TestsABSTRACT
Colorectal cancer (CRC) is among the leading causes of cancer deaths and can be caused by environmental factors as well as genetic factors. Therefore, we developed a prediction model of CRC using genetic risk scores (GRS) and evaluated the effects of conventional risk factors, including family history of CRC, in combination with GRS on the risk of CRC in Koreans. This study included 187 cases (men, 133; women, 54) and 976 controls (men, 554; women, 422). GRS were calculated with most significantly associated single-nucleotide polymorphism with CRC through a genomewide association study. The area under the curve (AUC) increased by 0.5% to 5.2% when either counted or weighted GRS was added to a prediction model consisting of age alone (AUC 0.687 for men, 0.598 for women) or age and family history of CRC (AUC 0.692 for men, 0.603 for women) for both men and women. Furthermore, the risk of CRC significantly increased for individuals with a family history of CRC in the highest quartile of GRS when compared to subjects without a family history of CRC in the lowest quartile of GRS (counted GRS odds ratio [OR], 47.9; 95% confidence interval [CI], 4.9 to 471.8 for men; OR, 22.3; 95% CI, 1.4 to 344.2 for women) (weighted GRS OR, 35.9; 95% CI, 5.9 to 218.2 for men; OR, 18.1, 95% CI, 3.7 to 88.1 for women). Our findings suggest that in Koreans, especially in Korean men, GRS improve the prediction of CRC when considered in conjunction with age and family history of CRC.
Subject(s)
Female , Humans , Male , Area Under Curve , Colorectal Neoplasms , Odds Ratio , Risk FactorsABSTRACT
The relative importance of soft, or qualitative, data over hard, or metric, data is now beginning to be recognized in clinical trials. This tendency can be seen in the recent importance attached to evaluating quality of life. It is said that acupuncture and moxibustion are used to cure the patient, not the illness. This makes it likely that the simple and convenient Visual Analogue Scale (VAS) will come into wide use henceforth in evaluating research in acupuncture and moxibustion. Therefore, we would like to take this opportunity to discuss how to make a VAS, how to analyze it, points to look for in implementing it, and the relation between VAS and similar methods.
ABSTRACT
Ginseng root saponins ( GRS ) was extracted from native ginseng.The dosage used was calculated according to the content of saponins.Immunosuppression in mice was induced in 15 days after implar- ting Ehrlich ascites carcinoma (EAC) subcutaneously in armpit, and in 5-11 days after implanting EAC into peritoneal cavity. GRS administered orally 50mg/kg- for 8 days did not prevent the atrophy of the thymus in tumor-bearing mice but rather aggravated it. GRS administered orally 50mg/kg for 14 days partially restored the suppressed phagocytosis of peritoneal macrophages in tumor-bearing mice. GRS administered orally 50mg/kg for 6 days somewhat restored the suppression of hemolysin formation in tumor-bearing mice 5 days after implanting EAC, But GRS given in the same route and dosage for 9 days, showed no effect on the suppression of hemolysin formation. GRS administered orally 50mg/kg for 10 days partially restored the suppression of delayed hypersensitive reaction in tumor-bearing mice.