ABSTRACT
Background@#Kangaroo mother care (KMC) has been proven by several studies to promote breastfeeding, but many of the studies focus on the success of exclusive breastfeeding, and less on its galactogenic effects. @*Objective@#We aim to determine the maternal serum prolactin levels and breastmilk volume of mothers who rendered KMC to their infants. @*Materials and Methods@#This is a randomized controlled, open-labeled, interventional study in the Neonatal Intensive Care Unit of a tertiary government hospital. Infants weighing < 2000 grams admitted in NICU Level II, together with medically stable mothers and no contraindication for breastfeeding were simultaneously enrolled. Primary outcome measures were maternal serum prolactin levels and expressed milk volume on day 3 and day 7 postpartum. Two-sample t-test was used to compare groups, and paired t-test to compare within groups. Tests were two-tailed, with a p-value of < 0.05 considered statistically significant. @*Trial Registration@#Australia-New Zealand Clinical Trial Registry ID ACTRN12614000218695 @*Results@#Fifty mother-infant dyads were equally allocated into KMC and control groups (p < 0.001). There was significantly larger milk volume on the third day (29.6 ± 27.8 mL vs 16.3 ± 26.1 mL; p < 0.001) and seventh post-partum day (72.4 ± 62.3 mL vs 47.3 ± 43.8 mL; p < 0.000). There were increased serum prolactin levels compatible with post-partum state. The increase was more evident in the KMC (5244 ± 2702 mIU/L, on the 3rd postpartum day versus 4969 ± 2426 mIU/L, on the 7th postpartum day, p = 0.996) compared to control group (4129 ± 2485 mIU/L on the 3rd postpartum day versus 3705 ± 2731 mIU/L on the 7th postpartum day, p = 0.301). @*Conclusion@#We noted a significantly larger milk volume in the KMC group. There was also a greater increase in the prolactin levels in the KMC group, but this did not reach statistical significance. Further studies should be done to determine mechanism of galactogenesis through KMC.
Subject(s)
Kangaroo-Mother Care Method , ProlactinABSTRACT
Shatavari, Asparagus racemosus is one of the most important herbal drugs used by Ayurvedic Vaidyas since ancient days. The drug is having wide range of therapeutic activity and mentioned as a Rasayan by ancient Ayurvedic texts. The main part used by Ayurvedic doctors is a root. It is mentioned as a tonic and having lactogenic function. Shatavari has also been successfully used by several Ayurvedic practitioners for Nervine disorders, Acid peptic diseases, certain infectious diseases and as a immunomodulant. Main use of this drug is in female disorders specially as a galactagogue and several menstrual disorders. Scientific fraternity is working on this drug at multidimensional level to prove this drug as a potent medicinal drug in multiple disorders. Various scientific studies are proved that this drug worked as a potent antitussive, antineoplastic, galactologue, antidiarroheal, and as immunomodulant. The main focus of this article is to review the scientific studies done on A.racemsosus mainly on its phytochemistry, pharmacology, therapeutic uses mentioned in both modern sciences as well as in ancient Ayurvedic texts. Additional attempt is made to find the clinical studies done on A.racemosus. The present review article includes the detailed scientific exploration of root extract of A.racemsosus in systematic way so that it can highlight future research prospects of this famous and commercially useful drug.
ABSTRACT
Objective To study the galactagogue effect of Maidang Rutong Granules on the lactation rats.Methods The milk volume,morphology of mammary gland,serum prolactin level and pituitary acidophil number in lactation rats and the growth improvement in suckling mice were observed after administrating various dosages of Maidang Rutong Granules to lactation rats by gastric gavage.Results Maidang Rutong Granules can promote the dilation and hyperplasia of acinus cavity and conduit in mammary gland,reduce the mammary interlobular fat connective tissue,significantly increase pituitary acidophil number and serum prolactin level,increase the milk volume of lactation rats and their offspring's body weight.Conclusion Maidang Rutong Granules exhibit significant galactagogue effect on lactation rats.