Neural mechanism and evaluation of decision-making function in obsessive-compulsive disorder / 上海交通大学学报（医学版）

Obsessive-compulsive disorder (OCD) is a chronic,disabling,mental disorder,which has been linked to significant abnormalities in certain brain areas,including the orbital frontal cortex and the anterior cingulate cortex.Neuroimaging studies have also shown that brain areas related to the decision-making function include the orbital frontal cortex and the dorsal prefrontal lobes.Furthermore,the association between OCD and decision-making function has been consistently demonstrated from a neurobiological perspective.Clinically,impaired decision-making ability is commonly observed in OCD patients,and there is a correlation between OCD and abnormal decision function.Decision-making tasks are typically divided into two types,decision-making under risk and decision-making under ambiguity,with the former commonly evaluated using the Iowa Gambling Task (IGT) and the latter using the Game of Dice Task (GDT).In this article the neural mechanism and evaluation methods of decision making in OCD were reviewed.

Trait anxiety has effect on decision making under ambiguity, but not decision making under risk / 中华行为医学与脑科学杂志

ObjectiveTo investigate whether the effects of trait anxiety on decision making under risk　and decision making under ambiguity are the same.Methods 185 subjects were grouped into high trait anxiety　(HTA),medium trait anxiety (MTA) and low trait anxiety (LTA) groups based on their trait anxiety scores.All　subjects were assessed by the Iowa Gambling Task (IGT),the Game of Dice Task (GDT) and the Wisconsin Card　Sorting Task (WCST).ResultsHTA and LTA subjects compared to MTA subjects were impaired in decision　making under ambiguity( MTA:2.08 ± 18.51 ; HTA:5.62 ± 20.35 ; LTA:5.94 ± 10.96,F =3.86,P =0.023 ),the relation between trait anxiety and IGT performance resembled the curved shape of an inverted U.Performances　of the three groups had no differences on decision making under risk (MTA:4.55 ± 10.17; HTA:4.00 ± 9.75;LTA:4.33 ± 11.20,F=0.03,P=0.968 ),and had no differences on executive functions and feedback processing.ConclusionTrait anxiety has effect on decision making under ambiguity,but not decision making under risk.The results provide support for the idea that decision making under ambiguity and decision making under risk are　different processes,moreover,support and extend the view that emotion has an impact on cognitive function.