Fatal Cutaneous gamma/delta T-Cell Lymphoma with Central Nerve System Metastasis

Cutaneous gamma/delta T-cell lymphoma is an extremely rare and highly aggressive tumor that is often resistant to treatment, such as polychemotherapy and radiotherapy. Due to the complexity of clinical, pathologic, and immunohistochemical features of this disease entity, the physician should perform a careful evaluation; however, treatment should be rapid and aggressive. We present a case of fatal cutaneous gamma/delta T-cell lymphoma of a 55-year old woman who died after recurrence with central nerve system metastasis.

Decrease of Double Negative T Cells with Aging: Analysis of alpha beta TCR and gamma delta TCR / 대한진단검사의학회지

BACKGROUND: In the previous study, we reported a decrease of CD4-CD8- double negative T (DNT) cells with aging. In this study we investigated the precise changes of two subsets of DN T cells, alpha beta TCR DN T cells and gamma delta TCR DN T cells, with aging. METHODS: We analyzed the T cell subsets by 3 color flow cytometry in a healthy young group (age 26.9+/-2.5, N=15), a healthy old group (age 67.7+/-3.4, N=15) and an old group with aging-associated diseases. RESULTS: The percentage of total DN T cells, alpha beta TCR DN T cells and gamma delta TCR DN T cells in total T cells, respectively, was 7.4+/-4.9%, 3.9+/-2.9% and 3.5+/-2.5% in a healthy young group and 3.5+/- 2.2%, 1.8+/-1.6%, 1.6+/-1.5% in a healthy old group. Both subsets decreased with aging significantly both P<0.05). Between a healthy old group and an old group with aging-associated diseases, we could not detect the significant difference of the percentage of either subset. CONCLUSIONS: This study confirmed our previous report. Furthermore, we observed that both subsets of DN T cells decreased in detail. More studies are needed to clarify the association between these findings and the aging-associated diseases.