Research progress of the ganoderan antitumor mechanism / 中国药学杂志

OBJECTIVE: To review mechanism research progress of ganoderan antitumor. METHODS: At the foundation of research literature of domestic and abroad, the different kinds of antitumor mechanism of ganoderan were summaried. RESULTS AND CONCLUSION: Now, polysaccharides become a research hotspot as antitumor immunomodulator. The study reviewed mechanism of ganoderan antitumor at different fields; elevating the immune function of host, inhibiting tumor cell proliferation and metastasis, anti-oxidant, clearing oxygen radicals, increasing the expression of tumor MHC and costimulatory molecules, inducing tumor cell differentiation. The study also observed the existent problem of ganoderan research.