ABSTRACT
Schinus terebinthifolius Raddi and the Myracrodruon urundeuva Allemão were evaluated in rats and mice for antiulcer effects, as these two plants are widely used in Brazil for gastric ulcer treatment. Extracts of the plants showed a marked protective effect against gastric ulcerations induced by immobilization stress at low temperature in rats. They also showed an increase in the pH and volume of the gastric contents, and reduction in gastric hemorrhage in rats, and decrease in intestinal transit in mice, even at the low doses of 3.4 mg/kg (1/4 of the dose used by humans).
Foram avaliados, em ratos e camundongos, os efeitos antiúlcera de duas plantas usadas popularmente no Brasil para o tratamento de "males gástricos": a Schinus terebinthifolius Raddi (aroeira-da-praia) e a Myracrodruon urundeuva Allemão (aroeira-do-sertão). Os decoctos de ambas as plantas apresentaram um marcante efeito protetor da mucosa gástrica contra as ulcerações induzidas por estresse de imobilização em baixa temperatura em ratos. Ambas as plantas apresentaram, ainda: elevação do pH, do volume do conteúdo gástrico, redução das hemorragias gástricas e do trânsito intestinal em camundongos, mesmo em doses tão reduzidas quanto 3,4 mg/kg (1/4 da dose utilizada pelo homem).
ABSTRACT
1. Seven cases with massive gastric hemorrhage resulting in profuse hematemesis form the basis of this report. Four of these were admitted in the Medical Wards of the Philippine General Hospital, two were patients admitted in the Pay Section of the same Hospital, and the sixth was an American internee admitted in a special ward for internees of the same hospital2. Four of these patients died, and a complete pathologic report for each was available. Two were operated on and accurate operative findings were also available for these patients. One had no operative or autopsy verification of the clinical impression. But this appears well supported by clinical laboratory and X-ray findings3. Four of these patients were found suffering from peptic ulcer and the other three from portal chirrhosis. The patients with peptic ulcer showed practically no bilirubin in the blood (Whether B-I or B-II) while those with portal cirrhosis showed significant amounts of B-I4. When clinical, laboratory , or x-ray findings are not sufficiently distinct for the differentiation of these two conditions in cases of massive gastric hemorrhage, the bilirubin (B-I) content of the blood may help in the differentiation. Peptic ulcer is not accompanied by B-I in the blood, while portal cirrhosis is always accompanied by functional disturbances of the liver. This is shown by the constant presence of B-I in the blood. (Conclusion)