Present situation and progress in yellow fever attenuated live vaccine / 中华微生物学和免疫学杂志

The yellow fever (YF) attenuated live vaccine 17D is one of the oldest attenuated live vaccines and historically well known for its good immunogenicity and safety. Because of the high safety of YF attenuated live vaccine 17D, its genome is used as the backbone of recombinant vaccines that deliver flavivir-uses or non-associated antigens. With the prevalence of YF, the demand for YF attenuated live vaccines is increasing. At present, there is insufficient supply of YF attenuated live vaccines in the world. Much atten-tion has been paid to YF attenuated live vaccines. In this paper, the quality, use and prospect of YF attenu-ated live vaccine are reviewed.