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Purpose To investigate the clinical effect of ultrasound guided drainage combined with different hardeners for simple breast cysts,and to further provide reference for individual treatment.Materials and Methods Clinical data of 117 cases breast simple cysts were analyzed retrospectively,of which 42 cases were routine ultrasound-guided puncture combined with fluid injection of hypertonic sugar (group A),40 cases were routine ultrasound guided drainage combined with ethanol injection therapy (group B),and 35 cases were routine ultrasound guided therapy alone (control group).The clinical efficacy and adverse reactions were compared among the three groups after treatment.Results The total effective rate of group A was 95.24％,group B was 97.50％,and control group was 82.86％.Total effective rate of group A and B had no significant difference (P＞0.05),which were both higher than control group (P＜0.05).The adverse reactions rate of group B was higher than group A and control group,which had statistical significance (P＜0.05).Conclusion Ultrasound guided injection of hypertonic sugar or ethanol after drainage treatment for simple breast cysts can both obtain satisfactory clinical results,but adverse reactions of the former one are mild,it should be widely applied.
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Objective To explore the clinical effect of intravenous injection of 50％ glucose combined with furosemide in the treatment of heart failure.Methods 71 patients with intractable heart failure were selected.According to the random number table,they were divided into the observation group (35 cases) and control group (36 cases).On the basis of conventional treatment,the observation group received continuous intravenous infusion of furosemide 100mg combined with intravenous injection of 50％ glucose 100ml.The control group was given intermittent injection of furosemide 300mg,3 times/day,100mg/each time.Treatment effects were compared between the two groups.The cardiac function,24h urine volume,BNP and ultrasound beckoning figure index including left ventricular end-diastolic diameter (LVEDD),ejection fraction (EF) before and after 72h treatment of the two groups were compared.Results The total effective rate of the observation group was 82.86％,which was significantly higher than 61.11％ of the control group (x2 =4.15,P ＜ 0.05).After treatment,cardiac functional grading,24 hour urine volume,BNP,EF and LVEDD of two groups were significantly improved,and compared with the control group,the improvement of the observation group was more significant,the differences were statistically significant (t =3.23,2.98,3.87,3.12,3.67,P ＜ 0.05).The incidence rate of adverse reaction of observation group was 8.57％,that in control group was 13.9％,there was no statistically significant difference between two groups (x2 =0.97,P ＞ 0.05).Conclusion Effect of furosemide combined with intravenous injection of 50％ glucose in the treatment of congestive heart failure is reliable,the cardiac function recovered well,and has high application value.
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Objective To study the resuscitative effect of hypertonic electrolyte glucose solution (HEGS) on the haemodynamics pa-rameters in enteral resuscitation of burn shock. Methods Eighteen beagle dogs with 35% TBSA third degree burned were used in this stud-y. They were random divided into no-resuscitation group (NR group), enteral resuscitation with HEGS group (EH group) and intravenous resuscitation with isotonic electrolyte glucose solution (lEGS) group (Ⅱ group). The fluid resuscitation was given from half an hour after TBSA). The haemodynamics parameters (cardiac index, mean arterial pressure, intrathoracic blood volume index, and systemic vascular re-sistance index) were continuously assessed by PICCO. Result The cardiac output index reduced markedly after bum in the three groups, and then returned after 2h in two resuscitation groups, which were higher than that in the NR group( P<0.05). The mean arterial pressure reduced in the three groups, which was higher in the two resuscitation groups than that in NR group(P < 0.05). The intrathoracic blood volume index was rapidly reduced in the three groups. It returned in EH group from 2 hours after burned, which was still higher than that in the other two groups (P < 0.05). Meanwhile the systemic vascular resistance index was increased quickly. It was reduced in EH group from 2 hours after burned, which was lower than that in the other two groups (P < 0.05). Conclusion The results show that it was feasible for 35% TBSAⅢ° burn-injury dogs to be resuscitated with 1.8% hypertonic electrolyte-glucose solution by enteral, which can markedly reduce liquid quantity needed.
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Objective To study the effects of high glucose and the leucocyte of diabetic patients on endothelial cells. Methods The leucocyte adhesion percentage to endothelial cells and the (MMP-9) expression of co-culturing endothelial cells and leucocytes were determined under different levels of glucose and at different time. Results (1) The level of MMP-9 was much higher under high glucose culture, and it increased as culture time prolonged. (2) The percentage of leucocyte adhesion to endothelial cells under high level of glucose was increased, and it was further enhanced when (co-culture) with leucocytes of diabetic patients . (3) The level of MMP-9 in supernatant of endothelial cells and leucocytes was increased significantly after culture with leucocytes of diabetic patients. It showed leucocytes were toxic to endothelial cells. Conclusions High glucose increases the level of MMP-9 of endothelial cells and percentage of the leucocyte adhesion to endothelial cells.Leucocytes of diabetic patients are toxic for endothelial cells.
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AIM: To study the role of p38 mitogen-activated protein kinase (p38MAPK) activation in high glucose-induced collagen Ⅲ synthesis in NRK52E cells. METHODS: Normal rat tubular epithelial cell line NRK52E was cultured in D-glucose of different concentrations, pretreated with SB203580 and collected at different time points. The levels of phospho-p38MAPK and extracellular matrix collagen Ⅲ were examined by Western blotting. RESULTS: The activation of p38MAPK was shown to be dependent upon D-glucose concentration and the time-course. Pretreatment with SB203580 blocked p38MAPK activation induced by high concentration of D-glucose in NRK52E cells. CONCLUSIONS: The activation of p38MAPK induced by high concentration of glucose may play a role in diabetic interstital renal fibrosis. SB203580 has a potential value of clinical applications in the prevention and treatment of diabetic nephropathy.