ABSTRACT
The renal cortical necrosis occurs in approximately 2% of adult patients with acute renal failure. The causes of renal cortical necrosis were usually associated with obstetrical problems. However, the distinctive changes occurred over the past 15 years in the etiology with a high incidence of non-obstetric causes than obstetric ones. We experienced a rare case of diffuse bilateral renal cortical necrosis in 16-year-old man who had a history of glue sniffing. To our knowledge, this is the first report in our country. A 16-year-old man was admitted with vague flank pain and oliguria. There was history of frequent adhesive glue sniffing. Laboratory data were as follows : BUN 77mg/dL, creatinine, 9.3mg/dL, protein 3+, RBC many/HPF, WBC 1-4/HPF in urinalysis, HBsAg(-), Anti-HBs(+), C(3)10.5mg/dL, C(4)7.4mg/dL), IgG 1,865mg/mL, IgA 512mg/mL. The kindey size was normal in ultrasonography. Renal cortex was diffusely not enhanced in MIJ Tl weighted image. Diffuse bilateral renal cortical necrosis was diagnosed by renal biopsy. In this case, adhesive glue sniffing may be a cause of acute cortieal necrosis.
Subject(s)
Adolescent , Adult , Humans , Acute Kidney Injury , Adhesives , Biopsy , Creatinine , Flank Pain , Immunoglobulin A , Immunoglobulin G , Incidence , Inhalant Abuse , Kidney Cortex Necrosis , Necrosis , Oliguria , Ultrasonography , UrinalysisABSTRACT
The inhalation of volatile substances has becoming a popular fad among adolescents in the world. Glue sniffing is associated with injury of nervous system, liver and kidney. And rarely abnormality of blood and bone marrow suppression can develop. The main components of volatile substances that cause hematologic abnormality is thought to be benzene, toluene, and xylene. A 24 year-old male was admitted to our hospital due to gum bleeding. He was a chronic glue and organic solvents sniffer for 6 years, and quit sniffing 1 year before admission. He had no specific drug history. On admission, CBC was as follows: WBC 2,500/mm3; hemoglobin 8.9g/dl; hematocrit 25.1%; platelet 2,000/mm3. Bone marrow biopsy showed severe hypocellular marrow compatible with aplastic anemia. We report a case of aplastic anemia after habitual sniffing of glue and volatile substances with brief review of the literature.
Subject(s)
Adolescent , Humans , Male , Young Adult , Adhesives , Anemia, Aplastic , Benzene , Biopsy , Blood Platelets , Bone Marrow , Flavin-Adenine Dinucleotide , Gingiva , Hematocrit , Hemorrhage , Inhalant Abuse , Inhalation , Kidney , Liver , Nervous System , Solvents , Toluene , XylenesABSTRACT
Toxic optic neuritis due to chronic glue sniffing was documented in a 25-year-old soldier who had a 2 year history of glue sniffing (toluene abuse). He had progressive visual loss three weeks prior to the admission. Slurred speech, unsteady gait, tremor and decline of his intelligence were also noticed. Examination revealed bilateral optic atrophic with visual acuity f hand movement recognition of both sides. Cerebella signs, frontal lobe releasing signs, dysarthria and tremor were demonstrated. Extensive investigations failed to show the causation of his optic neuropathy including cranial computerized axial tomography. After three week of abstinence from glue sniffing and administration of high dose vitamin B1, his visual acuity improved to the scale of 20/400 bilaterally and his speech, gait and fine movement returned to normal.