ABSTRACT
Objective To analyze the relationship and clinical significance of serum glutamyl transpeptidase (GGT) level with left atrial diameter.Methods All the newly diagnosed 200 essential hypertension patients with complete data were selected.They were divided into normal left atrial group and enlarged left atrial group based on the size of left atrial diameter.Fasting blood glucose,serum lipid,routine laboratory tests,hepatic and renal function and blood pressure were measured by routine methods,and compared between the two groups.Results The GGT level in the enlarged left atrial group was lower than that in the normal left atrial group among essential hypertension patients [(21.56 ± 11.95) U/L vs.(37.28 ± 12.64) U/L] (P =0.001).Spearman correlation showed that GGT level was negatively associated with left atrial diameter(r =-0.413,P =0.002).Multiple linear regression analysis showed that the serum GGT was also negatively correlated with left atrial diameter(β =-0.394,95 ％ CI:-0.131,-0.692;P =0.005).Conclusion Our study demonstrated that the level of GGT was negatively correlated with left atrial diameter among essential hypertension patients,and monitoring the changes of serum liver enzyme may have significant effect on the early detection of enlarged left atrial diameter.