Impulse Control and ERP Characteristics of Patients with Mental Disorder Caused by Traumatic Brain Injury / 法医学杂志

Objective To explore the impulse control and event-related potential （ERP） characteristics of patients with mental disorders caused by traumatic brain injury （TBI） in forensic psychiatry identification and to provide objective auxiliary indicators for forensic psychiatry identification. Methods Thirty patients （TBI group） with mental disorders caused by traumatic brain injury, who were identified as mild psychiatric impairment by judicial psychiatry, including 24 males and 6 females, as well as the thirty people in the control group participated in the study. All the participants completed Barratt Impulsiveness Scale-11 （BIS-11） and ERP induced by Go/NoGo tasks. BIS-11 and ERP data were collected and analyzed. Results The results of the BIS-11 showed that the total score and subscale scores of the TBI group were higher compared to the control group （P<0.05）. Moreover, the TBI group exhibited significantly lower NoGo-N2 amplitude and lower NoGo-P3 amplitude than the control group. The NoGo-N2 amplitude was larger than the Go-N2 amplitude, and the NoGo-P3 amplitude was larger than the Go-P3 amplitude in both groups （P<0.05）. Conclusion Traumatic brain injury could impair impulse control of mild psychiatric impairment patients, and the amplitudes of NoGo-N2 and NoGo-P3 could be important parameters to evaluate the impulse control of patients with mental disorders caused by traumatic brain injury.

Resolução de labirintos e tarefa agir/não agir na avaliação atentiva / Solving mazes and go/nogo task in attentive assessment

Os processos atentivos são fundamentais para o controle do comportamento e para o planejamento da ação. Este estudo investigou uma possível relação no desempenho de participantes (n=20) sem queixas clínicas na resolução de labirintos e na execução de um teste computadorizado de desempenho contínuo (Agir/Não Agir). O desempenho dos participantes foi analisado em termos de possíveis relações significativas entre o tempo médio de resolução dos labirintos e o tempo médio na execução da tarefa Agir/Não Agir, bem como uma possível relação entre os tipos de erros cometidos nas duas tarefas. Os resultados sugerem uma relação significativa entre o tempo de execução das duas tarefas e uma correlação entre a frequência de toques nos limites dos labirintos e a quantidade de erros de comissão cometidos em uma tarefa Agir/Não Agir. Esses resultados são discutidos em termos de possíveis marcadores comportamentais de ações impulsivas. (AU)

Attentive processes are critical to behavior control and action planning. The present study investigated a possible relationship in the performance of participants (n=20) without clinical complaints in solving mazes and in a computerized continuous performance test (Go/NoGo). The performance of participants was analyzed in terms of possible significant relationships between average time in the resolution of mazes and average time in implementing the Go/NoGo task, as well as a possible relationship between types of errors in both tasks. The results suggest a significant relationship between the runtime of both tasks and correlation between the frequency of touches at the limits of mazes and the amount of commission errors committed in Go/NoGo task. These results are discussed in terms of possible behavioral markers of impulsive actions. (AU)

An event-related potentials study on children with attention deficit hyperactivity disorder before and after EEG biofeedback therapy / 中华行为医学与脑科学杂志

Objective To examine the curative effect of EEG biofeedback therapy on children with attention deficit hyperactivity disorder (ADHD),and to investigate the neural mechanism underlying the executive function in children with ADHD.Methods 42 children with ADHD participated a Go/Nogo task before and after the EEG biofeedback therapy which was consisted of 20 times of treatments.The curative effect was evaluated using the behavioral and electrophysiological indexes associated with the Go/Nogo processing in the experiment.Results Commission error significantly decreased after the therapy ( (2.95 ±2.22 ) vs (4.65 ±4.47),P＜0.05 ).Latencies of P2 ( (210.00 ± 27.54) ms vs ( 228.27 ± 34.17 ) ms) and N2 components ( ( 310.59 ± 45.82) ms vs (328.00 ± 42.27)ms) elicited by Go trials significantly exhibited shorter at the end of therapy.Additionally,the amplitude of N2 component elicited by Nogo trials exhibited significantly decreased after therapy ((0.23 ±3.79)μV vs (-1.84 ± 4.23 ) μV,P ＜ 0.05).Conclusion The EEG biofeedback therapy is effective in debasing the hyperactivity/impulsive behaviors and improving the ability of target detection,which may be beneficial to the attention ability and conflict detecting in children with ADHD.EEG biofeedback is an effective treatment to ADHD.

Mood-Congruent Bias to Emotional Word, Face, and Scene Stimuli in Patients with Bipolar Mania : Comparison to Normal and Schizophrenia Subjects / 대한정신약물학회지

OBJECTIVE: Patients with bipolar mania have difficulty in recognizing or attending to negatively affective stimuli and have an affective bias, which is congruent with the current mood. However, previous reports have adopted words or facial pictures, not scenic pictures as affective stimuli. In this study, patients with mania performed the word, face and scenic picture-based affective go-nogo tasks respectively. The results were compared to those of patients with schizophrenia and healthy controls. METHODS: Twenty patients with bipolar mania, 20 patients with schizophrenia, and 20 healthy comparison subjects, matched for age, gender and intelligence, performed affective gonogo tasks which contained happy/sad words, facial pictures, and scenic pictures respectively. RESULTS: On the scenic picturebased affective go-nogo task, a significant interaction between subject group and target valence emerged {F (2, 57)=4.86, p<0.05}. Pairwise comparison showed the manic patients required significantly more time to respond to sad than to happy stimuli (t=3.22, df=19, p<0.01), but schizophrenia patents and healthy subjects did not differ in time to respond to happy or sad stimuli (t=1.95, df=19, p=0.07 ; t=-1.23, df=19, p=0.23). CONCLUSION: Manic patients displayed a mood-congruent bias toward affective scenic pictures, but not toward affective word or facial pictures. This finding suggests that complex and scenic stimuli may give a more influence on the affective arousal state and therefore increase the mood-congruent bias in manic patients.

Mood-Congruent Bias to Emotional Word, Face, and Scene Stimuli in Patients with Bipolar Mania : Comparison to Normal and Schizophrenia Subjects / 대한정신약물학회지

OBJECTIVE: Patients with bipolar mania have difficulty in recognizing or attending to negatively affective stimuli and have an affective bias, which is congruent with the current mood. However, previous reports have adopted words or facial pictures, not scenic pictures as affective stimuli. In this study, patients with mania performed the word, face and scenic picture-based affective go-nogo tasks respectively. The results were compared to those of patients with schizophrenia and healthy controls. METHODS: Twenty patients with bipolar mania, 20 patients with schizophrenia, and 20 healthy comparison subjects, matched for age, gender and intelligence, performed affective gonogo tasks which contained happy/sad words, facial pictures, and scenic pictures respectively. RESULTS: On the scenic picturebased affective go-nogo task, a significant interaction between subject group and target valence emerged {F (2, 57)=4.86, p<0.05}. Pairwise comparison showed the manic patients required significantly more time to respond to sad than to happy stimuli (t=3.22, df=19, p<0.01), but schizophrenia patents and healthy subjects did not differ in time to respond to happy or sad stimuli (t=1.95, df=19, p=0.07 ; t=-1.23, df=19, p=0.23). CONCLUSION: Manic patients displayed a mood-congruent bias toward affective scenic pictures, but not toward affective word or facial pictures. This finding suggests that complex and scenic stimuli may give a more influence on the affective arousal state and therefore increase the mood-congruent bias in manic patients.