ABSTRACT
The key point to define the psychological problem in children is the grasp of degree,also,the key point to educate children is the grasp of degree.Are there some principles to clarify the degree? How to quantify the degree? This paper brought forward the gold zone method of psychological guidance in children and adolescents and defined its quantitive expression as golden section.The gold zone method can grasp the scale set according to the goal,form the proper consumption value,control the interpersonal intimacy,cultivate fine thinking and behavioral pattern,and give appropriate guidance to many basic problems about children's growth.
ABSTRACT
OBJECTIVE: To reduce adverse drug reactions and resistance of cefamandole nafate for injection and ceftriaxone sodium for injection by gold zone method. METHODS: The relationships between doses and effects were studied. Using gold zone as the middle range and dividing empirical range into three sections are the keypoints to the study design. RESULTS: The incidences of drug adverse reactions of both drugs complied with U-shaped rule, i.e, with the increase of doses (mg·kg-1·d-1), the adverse reaction rates first decreased and then rose, and the bottom of the U-shaped curve was in the gold zone. Central limit theorem and normal distribution demonstrated that the appropriate doses existed in the gold zone, which was less than 1/4 of the empirical range but covered nearly 70% of the probability. The relationship between the resistance and dose also followed U-shaped rule, and the bottom of the U-shaped curve was also in the gold zone. CONCLUSION: Abuse, adverse reactions and resistance are the three major problems in antibiotics use today. Using gold zone method to determine dose may be a special breakthrough in solving these problems. Copyright 2012 by the Chinese Pharmaceutical Association.