ABSTRACT
The Chinese materia medica pharmaceutical process route designed for green manufacturing, also known as “green design”, aims to minimize the resource consumption and environmental effect of the life cycle of products process, coordinate and optimize economic and environmental efficiency. With membrane technology at the core of the pharmaceutical separation process technology closely related to green manufacturing of drugs. The three major requirements and maturity of “environment, performance, and cost” and separation technology principle are the basic elements of the pharmaceutical separation process green design. The development and adoption of clean technology not only conforms to the “principle of precautionary superior to governance”, but also reduces the consumption of raw materials and energy, and at the same time improves the economic efficiency of the enterprises. It is the best way to protect the coordinated development of the ecological environment and economic construction. In this paper, taking the construction of “membrane and resin technology system integration” as an example, the specific implementation plan for the green design of Chinese materia medica pharmaceutical process is introduced, and the technical economical problems in the design of pharmaceutical separation process are analyzed and discussed.
ABSTRACT
Traditional Chinese medicine (TCM) is China’s original advantages of the field of science and technology. TCM inheritance innovation research has been promoted to national science and technology strategy. Membrane technology is adapt to the efficacy and advantages of multiple features of Chinise materia medica (CMM) substance, which can fully realize the core value of CMM resources, and it has high efficiency, energy saving, pollution-free features. The use of membrane technology in TCM is the high-tech that needs to be promoted. This paper summarized the authors’ study for more than 10 years, focusing on “CMM pharmaceutical separation engineering technology system and application based on membrane process”. In order to solve the problems of low production efficiency, high energy consumption, high pollution and low sterilization efficiency, membrane technology is taken as the core. Through the construction of “CMM solution environment” scientific hypothesis, computer chemistry established based on CMM film mass transfer process research methods; According to the bottleneck of engineering application of membrane technology in CMM, CMM green manufacture series of key common technology was established. The establishment of characteristics of CMM in line with the characteristics of environmentally friendly production lines to achieve the CMM production in the preparation of “extraction, refining, enrichment” and other aspects of efficient, environmentally friendly, stable and intelligent control. CMM’s membrane technology takes water as the basic solvent, which can retain the CMM’s characteristics; The membrane technology and its sets of equipment have been extended to 29 provinces nationwide, resulting in significant social and economic benefits. Of which the production cycle of the product unit is shortened, the energy consumption is reduced, the resource utilization rate is increased, the labor productivity is increased, the retention rate of the main indicator component is more than 95%; And achieved great economic benefits at the same time. Membrane technology is fully consistent with the construction of resource-saving and environment-friendly society, which is worthy of the key technology of CMM green manufacture, to promote China’s pharmaceutical industry, technological progress, improve labor productivity and resource utilization has an important role. Membrane technology has a broad application prospects.