ABSTRACT
Linaclotide is the first secretagogue approved for the treatment of irritable bowel syndrome with constipation in China. A group of experts in digestive diseases was convened to discuss the clinical use of linaclotide in China on June 26, 2021. Experts concluded at the seminar that the clinical efficacy of linaclotide should be comprehensively evaluated based on the improvement of constipation and abdominal symptoms; the clinicians should emphasize the importance to patient satisfaction; and the administration time, dose and duration of linaclotide treatment can be optimized according to the treatment response, lifestyle, severity of symptoms and drug sensitivity. In addition, the experts believed that communication with patients should be strengthened to help them to establish reasonable expectations to the efficacy and optimize the treatment regimen timely according to their feedback.
ABSTRACT
Guanylyl cyclase C( GCC)is a specific intestinal tissue polypeptide expressed in intestinal epithelial cells,and is also expressed in colorectal cancer cell line and primary and metastatic colorectal cancer. Studies have indicated that level of GCC mRNA in blood could contribute to the early detection of colorectal cancer metastasis and recurrence,and is beneficial to the formulation of therapeutic regimen and follow-up. This article reviewed the progress in research on GCC in diagnosis and treatment of colorectal cancer.
ABSTRACT
Objective To explore the correlation of preoperative guanylate cyclase C (GC-C) mRNA in peripheral blood with postoperative gastric cancer recurrence. Methods The preoperative blood samples were collected from 60 patients with gastric cancer (GC) before operation, also from 21 patients with dysplasia, 15 with intestinal metaplasia, and 20 healthy volunteers during the same period. GC-C mRNA in the peripheral blood samples was assessed by real-time fluorescent quantitative PCR (RFQ-PCR). The association of peripheral blood GC-C mRNA expression with pathological parameters and gastric cancer recurrence was analyzed. Results The positive rate of preoperative GC-C mRNA in blood samples of gastric cancer patients (48. 3% [29/60]) was significantly higher than that of patients with dysplasia (20. 0%[3/21], P