Effect of Pin Holes Location of Unicompartmental Knee Arthroplasty on Postoperative Tibial Plateau Mechanical Properties / 中国医疗器械杂志

OBJECTIVE@#The purpose of this study is to explore the biomechanical characteristics of the tibia after unicompartmental knee arthroplasty with different distributions of two-pin holes, and to optimize the two-pin holes scheme to reduce the risk of tibial fractures after unicompartmental knee arthroplasty.@*METHODS@#Lower limbs model is segmented and reconstructed from computed tomography images. Four combinations of two pin holes created for tibial cutting guide placement are simulated with finite element analysis.@*RESULTS@#In the third mode, the positioning hole at the proximal medial edge of the tibial plateau has the highest stress value, and the position of the positioning hole near the medial edge of the proximal tibial plateau appears stress concentration.@*CONCLUSIONS@#The present study revealed that placing tibial cutting guide holding pins centrally would lower the risks of periprosthetic fracture of the medial tibial plateau.

Simultaneous implantation and tooth preparation technology guided by 3D-printed guide / 华西口腔医学杂志

Using digital technologies in concurrently performing missing tooth implantation and preparation of remaining teeth is a solution to reduce the number of visits and improve efficiency. This paper proposes a digital process for simultaneously implanting and preparing teeth. It integrates implant surgical guide and 3D-printed tooth preparation guide into a single guide and completes guided implant placement and precise tooth preparation. Based on "repair-oriented" virtual implant planning, the implant surgical guide can improve the efficiency and predictability of implant placement, and its linear accuracy is about 1 mm. The tooth preparation guide precisely guides tooth preparation and restoration space visualization, ensuring the quality of the tooth preparation. The two guides have different design accuracy requirements, and thus their combination improves the overall guiding accuracy requirements. The concurrent application of the two guides minimizes the clinical operation time, number of visits, and economic burden of patients.

Pharmacokinetics and tissue distribution of four alkaloids in Ermiao Pills and Sanmiao Pills in normal and arthritic model rats / 中国中药杂志

This work aimed to investigate the differences of pharmacokinetics and tissue distribution of four alkaloids in Ermiao Pills and Sanmiao Pills in normal and arthritic model rats. The rat model of arthritis was established by injecting Freund's complete adjuvant, and ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) in the positive ion multiple reaction monitoring(MRM) mode was used for the determination of four alkaloids in plasma and tissues of normal and arthritic rats after administration of Ermiao Pills and Sanmiao Pills, respectively. The differences in pharmacokinetics and tissue distribution of the four active components were compared, and the effect of Achyranthis Bidentatae Radix on the major components of Sanmiao Pills was explored. This study established an UPLC-MS/MS for simultaneous determination of four alkaloids, and the specificity, linearity, accuracy, precision, and stability of this method all met the requirements. Pharmacokinetics study found that as compared with normal rats, the AUC and C_(max) of phellodendrine, magnoflorine, berberine and palmatine in model rats were significantly decreased after administration of Ermiao Pills, the clearance rate CL/F was significantly increased, and the distribution and tissue/plasma concentration ratio of the four alkaloids in the liver, kidney, and joint were significantly reduced. Achyranthis Bidentatae Radix increased the AUC of phellodendrine, berberine, and palmatine, reduced the clearance rate, and significantly increased the distribution of the four alkaloids in the liver, kidney, and joints in arthritic rats. However, it had no significant effect on the pharmacokinetics and tissue distribution of the four alkaloids in normal rats. These results suggest that Achyranthis Bidentatae Radix may play a guiding role in meridian through increasing the tissue distribution of effective components in Sanmiao Pills under arthritis states.

Meridian Tropism and Compatibility of Chinese Medicine from Theory of Brain Sweat Pore / 中国实验方剂学杂志

Since LIU Hejian proposed the concept of sweat pore， the theory of sweat pore has experienced accelerated development. Especially with the advances in modern human anatomy and physiology， the microscopic anatomy of sweat pore begins to focus on the intercellular space， ion channels and other membranous space with channels， pores， doors， etc.， which exert the functions of exchanging fluid， information， and energy inside and outside blood vessels and discharging metabolic wastes so as to maintain the normal operation of organs. Therefore， sweat pore is the structural basis for the movement of Qi and the central link of Qi-fluid exchange in the body. The brain， as the house of original spirit， is in charge of the spirit of five Zang-organs. The brain sweat pore is pivotal for the circulation of Qi， blood， and fluid in the brain， and it is the structural basis for the normal physiological functions of the brain. The dysfunction of the brain sweat pore will cause the stagnation of Qi and the abnormal transport of blood and fluid. It will cause the abnormal exchange of Qi， liquid and other material and information， which fail to nourish the original spirt and cause the loss of vital activity， eventually leading to consciousness and emotion disorders. The treatment should focus on opening the brain sweat pore， smoothing the exchange of Qi and fluid inside and outside the pore， and restoring the Qi movement， so as to cure encephalopathy. At present， western medicine treatment of encephalopathy needs to solve the problem of drug efflux from the blood-brain barrier and improve the effective concentration of drugs into the brain. The structure and function of brain sweat pore is similar to those of the blood-brain barrier. The aromatic resuscitative medicines and wind-extinguishing medicines can open the brain sweat pore. When being combined with other medicines， they can lead the medicine to enter the brain to restore the Qi movement of the brain sweat pore and enhance the therapeutic effect. Liver-pacifying wind-extinguishing medicines， insect medicines， tonifying medicines， heat-clearing toxin-removing medicines， and damp-draining medicines can treat pathological factors such as wind， phlegm， stasis， deficiency， toxin， and dampness， respectively. These medicines， combined with the medicines with the tropism to brain meridians， can open the brain sweat pore and guide the medicine into the brain to enhance the effective concentration of the medicine， thereby enhancing the efficacy against encephalopathy.

Snare Guiding Technique in Bifurcated Endovascular Repair of Abdominal Aortic Aneurysm with Severely Tortuous Iliac Artery Access: A Case Report

@#Endovascular aneurysm repair (EVAR) has gained acceptance as a viable alternative to open surgical treatment for abdominal aortic aneurysm (AAA). We report the use of snare guiding wire in bifurcated EVAR case with severely tortuous femoral access. A 63-year-old man referred to the hospital from another facility with complaints of pulsating mass in right iliac and umbilical region for the last 2 years. He was then admitted to the cardiac catheterization lab for EVAR under general anaesthetic. Endovascular aneurysm repair (EVAR), also known as an endoprosthesis, is a stent-graft device-guided therapy for a AAA. This procedure is a safer choice for individuals who are elderly or have pulmonary, cardiac, or renal problems. Tortuous iliac arteries might obstruct device delivery during EVAR. The Snare Guiding Wire approach might be an alternate method for EVAR to treat AAA if conventional cannulation is difficult or impossible in individuals with highly tortuous iliac access.

Application value of Overlap guiding tube in Overlap esophagojejunostomy of laparoscopic total gastrectomy / 中华消化外科杂志

Objective:To investigate the application value of Overlap guiding tube (OGT) in Overlap esophagojejunostomy of laparoscopic total gastrectomy.Methods:The retrospective and descriptive study was conducted. The clinicopathological data of 5 patients with gastric cancer who were admitted to Nanfang Hospital of Southern Medical University from June to July in 2021 were collected. There were 3 males and 2 females, aged from 48 to 61 years, with a median age of 54 years. Patients underwent laparoscopic total gastrectomy combined with OGT-assisted Overlap esophagojejunostomy. Observation indicators: (1) surgical situations; (2) postoperative situations; (3) follow-up. Follow-up was conducted by outpatient examination and telephone interview to detect postoperative anastomotic stenosis and esophageal reflux up to September 2021. Measurement data with normal distribution were represented as Mean± SD, and measurement data with skewed distribution were represented as M(IQR) or M(range). Count data were represented as absolute numbers. Results:(1) Surgical situations: 5 patients underwent laparoscopic total gastrectomy combined with OGT-assisted Overlap esophagojejunostomy and D 2 lymph node dissection success-fully, achieving R 0 resection. There was no combined organ resection, intraoperative conversion to laparotomy or combined thoracotomy. There was no intraoperative conversion to other esophagoje-junostomy method either. The tumor diameter, length of surgical incision, the number of lymph nodes dissected, time of esophagojejunal anastomosis, time of digestive reconstruction, operation time, volume of intraoperative blood loss of 5 patients were 3.0(2.8)cm, 5.0(2.0)cm, 47.0(21.0), 21.0(5.0)minutes, 62.0(23.0)minutes, 295.0(75.0)minutes, and 50.0(60.0)mL, respectively. The anvil fork of linear stapler was successfully inserted into esophageal lumen by once operation in 4 cases of 5 patients and by twice operation in 1 case to complete the esophagojejunostomy. (2) Post-operative situations: the time to first out-of-bed activities, time to postoperative first anal flatus, time to postoperative initial liquid diet intake, time to postoperative initial semi-liquid diet intake, time to abdominal drainage tube removal, duration of postoperative hospital stay of 5 patients were 2.0(1.0)days, 3.0(2.0)days, 4.0(3.0)days, 6.0(3.0)days, 7.0(4.0)days, and 9.0(6.0)days, respectively. Results of postoperative pathological examination of 5 patients showed gastric adenocar-cinoma in all the 5 patients, with the TNM staging as stage pT2-4aN0M0. The esophageal surgical margin was negative in all cases, and the length of proximal margin from esophagus was 5.0(4.0)cm. None of the 5 patients developed anastomotic leakage, anastomotic bleeding or anastomotic stenosis. Two cases with mild pneumonia (Clavien-Dindo grade Ⅱ) were cured by conservative treatment such as anti-infection and expectoration promotion. There was no unplanned secondary surgery or perioperative death occurred to the 5 patients. (3) Follow-up: 5 patients were followed up for 3 months. None of the 5 patients developed anastomotic stenosis or esophageal reflux during the follow-up. Conclusion:OGT-assisted Overlap esophagojejunostomy of laparoscopic total gas-trectomy is safe and feasible, with good short-term effects.

Clinical research progress of motion style acupuncture / 国际中医中药杂志

Motion style acupuncture is generally used in combination with the movement therapy of affected parts in the process of needle acupuncture. In the process of acupuncture, the "movement" of the affected part can play a targeted guiding role in "spirit" and "Qi", It can lead the mind (spirit) and Qi to the place of disease, so as to achieve the realm of "treating spirit", "guiding Qi" and "keeping Qi", and eliminate diseases by activating the self-healing force of the human body. It is not only an important operation method of this acupuncture, but also the core idea and the key to take effect. In this acupuncture method, local acupoints or acupoints on the distal unaffected side are selected for acupuncture. The exercise methods include active and passive exercise. In the treatment of depression syndrome, hiccup, angina pectoris and other medical diseases, they often cooperate with respiratory exercise, as well as massage and self feeling. This acupuncture method is mostly used in the treatment of orthopedic and traumatological diseases, and can also treat facial paralysis, depression, anxiety, stroke and stroke sequelae, hiccup, angina pectoris and other medical diseases. It is less used in gynecology, or facial features. The treatment effect is better than simple acupuncture. It can also be combined with electroacupuncture, Traditional Chinese Medicine and Western medicine to improve the curative effect. In the future, it is necessary to further explore the relevant dominant diseases and explore the exercise methods more suitable for the relevant diseases. More attention should also be paid to the thinking of exercise inducing Qi and the concept of treating God contained in this acupuncture method.

Problems and countermeasures on pharmacovigilance system of 15 marketing authorization holders in Shanghai / 中国药房

OBJECTIVE To provide policy referen ce for local marketing authorization holder （MAH）to implement their main responsibility of drug life cycle supervision and the Guiding Principles of Pharmacovigilance Inspection to be officially released. METHODS Taking 15 MAH in Shanghai who recently underwent pharmacovigilance inspection as the research objects ，the social network analysis was used to explore the logical relationship between MAHs ’enterprise attributes and inspection problems ， summarize the problems found ，analyze the causes ，and put forward corresponding countermeasures. RESULTS & CONCLUSIONS The problems found in this pharmacovigilance inspection were mainly in aspects of organization ，personnel management ，quality management system ，report quality and so on. The reasons for these problems included light punishment ，which lead to the enterprise management ’s lack of attention to the pharmacovigilance system ，unclear problem handling and risk control mechanism ， imperfect quality management system documents ，inadequate personnel training ，etc. MAH needs to pay more attention to pharmacovigilance，allocate corresponding human and resources ，constantly improve the pharmacovigilance quality management system，and improve the enforceability and effectiveness of the pharmacovigilance system. At the same time ，it is suggested that government departments should strengthen policy guidance ， publicity and implementation ， and combine with third-party institutional platforms such as industry associations to promote the smooth implementation of Good Validation Practice .

Overview and changes of Guiding Principles of Clinical Application of Novel Anti -tumor Drugs over the years / 中国药房

OBJECTIVE To provide the suggestions and reference for the follow-up update of Guiding Principles of Clinical Application of Novel Anti -tumor Drugs （hereinafter referred to as “Guiding Principles ”）. METHODS The update of 2018-2021 editions of Guiding Principles were compared ；the changes of its style ，the variety and quantity of novel anti-tumor drugs ，the classification of indications ，the target ，the inclusion of medical insurance and other aspects were analyzed. Its change trend and possible problems were summarized. RESULTS There was a great change in the style of Guiding Principles in 2020 edition，i.e. deleting the item of “clinical application management ”and adding the item of “attached table ”. Totally 33 novel anti-tumor drugs were included in the 2018 edition of Guiding Principles ，and the number of novel anti-tumor varieties increased to 46，60 and 77 in 2019，2020 and 2021 editions，respectively. The time when the new varieties were included in Guiding Principles was the same year or one year after the domestic market time. Totally 26 varieties of national medical insurance negotiation were included in the 2018 edition of Guiding Principles ，and 8，10 and 12 varieties were added respectively in 2019，2020 and 2021 editions on the basis of the previous edition . Novel anti-tumor drug in the 2018 edition of Guiding Principles mainly focused on traditional targets such as EGFR，HRE2 and VEGFR. However ，since 2019，the number of new targets such as PD-1，PARP，ALK and CDK had been increasing，among which domestic original drugs accounted for a large proportion. CONCLUSIONS The revision of Guiding Principles aims to further guide the clinical application of novel anti-tumor drugs from the professional level of health technology. The new varieties and indications conform to the principles of scientificity and dynamics ；domestic original varieties have developed rapidly ，and innovative varieties to novel target have emerged. The follow-up update of Guiding Principles should refer to authoritative medical guidelines and high-quality evidence- based evidence. Attention should be paid to the types of tumors lacking therapeutic drugs and the clinical value of oushun- novel anti-tumor drugs.

Research on the features of public hospital high-quality development based on five core indicators / 中华医院管理杂志

Based on the five core indicators (the case mix index, the proportion of level-4 surgery, the proportion of technical service income in medical income, the proportion of personnel expenditure in business expenditure, and the proportion of fixed part in personnel salary), the authors discussed the guiding significance of " paying attention to the medical level, strengthening the functional orientation, reflecting the technical value, highlighting people-orientation, and ensuring sustainable development" in the high-quality development of public hospitals. In combination with the current situation of a pilot hospital of high-quality development with the corporate supports of National Health Commission and Province Government, the authors explained the common bottlenecks of public hospitals, such as inaccurate functional positioning, weak innovation ability, poor finance structure, poor salary system and insufficient attention to talents. In the last, the authors pointed out that high-quality development was the development of deepening reform, innovation driven, structural optimization, talent oriented, people-oriented and under the leadership of the Communist Party of China, and put forward targeted implementation paths to provide reference for the pilot work.

Study on the mechanism of "guiding action" of borneol in Suxiaojiuxin pills / 药学学报

In order to research the mechanism of guiding action of borneol in Suxiaojiuxin pills, the model of in vitro intestinal absorption, in vivo drug metabolism of mice and cell in vitro absorption model of Caco-2 were established firstly. All animal experiments were in accordance with the regulations of the Animal Ethics Committee of Nankai University. The results showed that the cumulative absorption quantity and absorption permeability of ferulic acid and ligustilide in the intestinal juice of Suxiaojiuxin pills group were significantly increased comparing with fake Suxiaojiuxin pills group, which don't contain borneol. By using borneol, the content of ferulic acid and ligustilide in the blood and tissues, such as heart, were added. The transepithelial resistance value and the content of horseradish peroxidase (HRP) in Caco-2 were rapidly decreased and increased, respectively. Due to further explore mechanism of promoting intestinal absorption of borneol for drugs, in this study, photosensitive probes of borneol were synthesized to capture its targets, and dual luciferase reporter system was used to evaluate its activity of calcium. It was found that it could make calcium overload by regulating transient receptor potential cation channel, subfamily M, member 8 (TrpM8). Then, the results of mass spectrometry imaging showed that the accumulation of ferulic acid in the heart was significantly increased by borneol, and the relaxation rate of rat thoracic aorta was enhanced obviously. In summary, the borneol in Suxiaojiuxin pills can expand cell space and increase intestinal permeability by acting on TrpM8, thus promoting the intestinal absorption, tissue distribution and target organ enrichment of drugs.

La orientación educativa del docente de ciencias médicas ante la covid-19 / The educational guiding of the medical science teacher to covid-19

RESUMEN Introducción: la orientación educativa, desde la relación profesor-alumno, es esencial para el tránsito del joven por los estudios superiores; requiere atención especial en el período de enfrentamiento a la covid-19 y es fundamental para el estudiante de ciencias médicas. Objetivo: identificar la percepción de la función orientadora del docente ante la covid-19 en estudiantes de ciencias médicas. Materiales y métodos: se realizó un estudio descriptivo, transversal en el período comprendido entre abril y octubre de 2020. El universo de trabajo estuvo representado por 18 estudiantes de primer año de la carrera de Medicina, de la Facultad de Ciencias Médicas de Mayabeque, que realizan la pesquisa en una comunidad perteneciente al Policlínico Docente Dr. Luis Li Trigent. Se analizaron datos como la existencia del profesor como orientador, áreas de la orientación educativa, problemas de los estudiantes y valoración de la comunicación empática profesor-estudiante. Resultados: los estudiantes reconocen la existencia del profesor como orientador. El área de orientación educativa de mayor incidencia en que se expresó la función orientadora del profesor fue la académica. Los problemas predominantes identificados por los estudiantes están relacionados con el proceso de enseñanza-aprendizaje. Existió una valoración positiva de la comunicación empática profesor-estudiante. Conclusiones: la relación profesor-alumno se hace más relevante durante la pandemia de covid-19. El estudiante de Medicina enfrenta nuevas condiciones en el proceso docente-educativo y demanda la orientación del docente (AU).

ABSTRACT Introduction: educational orientation, from the teacher-student relationship, is essential for the transit of the youth through higher education; it requires special attention in the period of confrontation with covid-19 and is essential for the student of medical sciences. Objective: to identify the perception of the teacher's guiding function in facing covid-19 in medical sciences students. Materials and methods: a descriptive, cross-sectional study was carried out in the period between April and October 2020. The universe of work was represented by 18 first-year students of the Medical pregraduate course, from the Faculty of Medical Sciences of Mayabeque, who carry out the research in a community belonging to the Teaching Polyclinic Dr. Luis Li Trigent. The existence of the teacher as a counselor, areas of educational orientation, student problems and assessment of empathic teacher-student communication were among the analyzed data. Results: the students recognize the teacher's existence as a counselor. The area of educational guidance with the highest incidence in which the teacher's guiding role was expressed was the academic one. The predominant problems identified by students are related to the teaching-learning process. There was a positive assessment of empathic teacher-student communication. Conclusions: the teacher-student relationship becomes more relevant during the covid-19 pandemic. The medical student faces new conditions in the teaching-educational process and demands the guidance of the teacher (AU).

Currículos prescritos em projetos sociais vinculados às atividades físicas e esportivas / Curriculums prescribed in social projects linked to physical and sports activities

Analisa os documentos institucionais de três projetos sociais e de um Serviço de Convivência e Fortalecimento de Vínculos (SCFV), a fim de compreender os modos como as atividades físicas/esportivas estão organizadas nesses contextos. Trata-se de uma pesquisa documental, na qual empregamos uma análise descritivo-interpretativa para examinar criticamente os documentos institucionais orientadores das práticas pedagógicas. Os dados apontam para o desenvolvimento de aspectos morais e éticos dos participantes, para a valorização da autonomia e do protagonismo dos sujeitos, bem como para questões sociais mais amplas, como a cidadania, o combate ao racismo, a preservação da cultura popular e a importância da educação ambiental. Uma das principais fragilidades encontradas nos documentos analisados é de natureza procedimental e está circunscrita na imprecisão de como as atividades físicas e esportivas serão trabalhadas para atingir os objetivos propostos.

The paper analyzes the institutional documents derived from three social projects and from a Living the Service and Strengthening Linkages (Serviço de Convivência e Fortalecimento de Vínculos (SCFV), in order to understand how the physical/sports activities are organized within these contexts. It is a documental research, in which a descriptive-interpretative analysis was used to critically examine the institutional policy documents of pedagogical practices. Data point to the development of moral and ethical aspects of the participants, to the appreciation of autonomy and the protagonism of the ones involved, as well as to wider social issues, such as, citizenship, the fight against racism, the preservation of popular culture and the importance of environmental education. One of the main weaknesses found in the analyzed documents has a procedural nature and is circumscribed in the inaccuracy of how physical and sports activities will be performed to achieve the proposed goals.

Improvement of ultrasound positioning technique for peripherally inserted central catheter tip position in neonates / 中华实用儿科临床杂志

Objective:To explore a new method of ultrasound-guided positioning of the tip of neonatal peri-pherally inserted central catheter (PICC).Methods:Clinical data of 174 newborn infants hospitalized in the Neonatal Intensive Care Unit (NICU) of Beijing Chaoyang District Maternal and Child Healthcare Hospital from January 2019 to April 2021 receiving PICC catheter intubated under the guidance of ultrasound for positioning the tip were retrospectively analyzed to explore the accuracy, reliability and feasibility of the improved ultrasound-guided positioning technique.Before lower extremity catheterization, ultrasound was performed to monitor the vascular pattern and catheterization of PICC was conducted under the guidance of ultrasound.Results:(1) Among 174 infants intubated with ultrasound-guided positioning of the PICC tip, 172(98.9%) of them had the ideal position, and 2(1.1%) did not achieve the ideal position, but achieved the ideal position after ultrasound-guided correction.(2) Lower extremity venous catheterization was successfully performed at 100.0% after ultrasound-guided monitoring of blood vessels.The time-consuming of lower extremity venous catheterization was significantly shorter than that of the previous method [(31.50±2.58) min vs.(56.10 ±5.30 min)]( t=46.84, P<0.001). The total success rate of catheterization and catheterization of lower limb vein increased by 7.0% and 17.5%, respectively.(3) Only 1 (0.57%) case reported the complication of catheter tip thrombosis, the complication rate of which decreased from the previous 79.00% to 2.70%(2/112 cases). Conclusions:The improved ultrasound-guided positioning of the PICC tip is convenient, simple, faster and accurate, which enhances the success rate and is worthy to be applied in clinical practice.

Discussion on "guiding meridian sinew / 中国针灸

It is to determine the effect mechanism and therapeutic method of the idea as "guiding meridian sinew

Guiding mechanism of platycodin D in treatment of mouse lung cancer with doxorubicin / 中国中药杂志

This study is to observe whether platycodin D has the guiding role in treatment of mouse lung cancer with doxorubicin and explore its guiding mechanism. In vitro, platycodin D and doxorubicin(alone or in combination) were added into Lewis lung cancer(LLC) cells to detect the cell proliferation and doxorubicin uptake. Cell morphological changes were analyzed by cell holographic analysis system; cell gap junctional intercellular communication(GJIC) was tested by fluorescent yellow tracer; lyso-tracker red was used to examine lysosomal function; LC-3 B(Light chain 3 beta)and P62(heat shock 90-like protein)staining were used to test auto-phagy and autophagic degradation respectively; and P-glycoprotein(P-gp) expression was examined by Western blot. In vivo, lung solid tumor was formed in mouse LLC cells via intravenous injection. Platycodin D and doxorubicin(alone or in combination) were used to treat tumor-bearing mice for four weeks, and then the tumor size was examined, mouse survival time was recorded, doxorubicin uptake in lung tissues was tested, and lung tissues were stained for observation by HE(hematoxylin-eosin) and immunohistochemistry. The results showed that platycodin D at the experimental concentration had no effect on LLC cell proliferation but decreased LLC cell volume, promoted the cells to uptake doxorubicin and enhanced the inhibitory action of doxorubicin on cell proliferation. Platycodin D could promote GJIC and lysosomal function, increase autophagy and autophagic degradation and suppress P-gp expression. Platycodin D at the experimental dose in this study had no effect on LLC lung solid tumors in mice, increased doxorubicin uptake in lung tissues and enhanced the therapeutic efficacy of doxorubicin on lung solid tumors. Platycodin D could improve the extracellular matrix deposition in lung solid tumors, decreased the lung mucin 5 AC secretion and pulmonary vessel permeability. In summary, platycodin D had the guiding role in treating mouse lung cancer with doxorubicin, and its guiding mechanism may be associated with the promotion of cell communication, lysosomal function, and improvement of extracellular environment.

Travessia da aventura: da ausência na escola à inclusão em documentos orientadores / Crossing the adventure: from school absence to inclusion in guiding documents / Cruzando la aventura: de la ausencia escolar a la inclusión en documentos de orientación

O trabalho se dedica a percorrer processos histórico sociais e produções acadêmicas que dão indícios do caminho para inserção das Práticas Corporais de Aventura na Educação Física Escolar. Como opção metodológica foi utilizada a revisão de literatura. Foi possível perceber que a modificação do entendimento do papel da Educação Física na escola, associada a um perfil mais autoral dos professores, com um crescente interesse acadêmico sobre a aventura, bem como, o aumento da visibilidade sobre as práticas de aventura foram razões que entrelaçadas podem ser entendidas como os fatores que possibilitaram a inclusão destas práticas na escola.

The work is dedicated to go through historical social processes and academic productions that give indications of the path for the insertion of Corporal Adventure Practices in Physical Education at School. The text is an essay that emerges from a literature review research. It was possible to perceive that the change in the understanding of the role of Physical Education in school, associated with a more authorial profile of teachers, with a growing academic interest in adventure, as well as the increase in visibility about adventure practices, especially in the commercial sphere, were reasons that were intertwined. can be understood as the factors that made it possible to include these practices in school, regardless of the guiding documents.

El trabajo está dedicado a pasar por procesos sociales históricos y producciones académicas que dan indicaciones sobre el camino para la inserción de las prácticas de aventura corporal en la educación física en la escuela. El texto es un ensayo que surge de uma insvestigación de revisión de literatura. Fue posible percibir que el cambio en la comprensión del papel de la Educación Física en la escuela, asociado con un perfil de más autoridad de los docentes, con un creciente interés académico en la aventura, así como el aumento de la visibilidad sobre las prácticas de aventura, especialmente em el campo comercial, fueron razones que se entrelazaron. pueden entenderse como los factores que hicieron posible incluir estas prácticas en la escuela, independientemente de los documentos rectores.

Discussion on the academic system of "theory, method, recipe and degree" in s infantile Chinese massage of the western part of Hunan province / 中国针灸

The theory and technique of s infantile Chinese massage of the western part of Hunan province are reviewed in clinical diagnosis and treatment and the core theoretical system is refined. Based on clinical experiences and in consideration of the analysis on relevant literature, the academic system of s infantile Chinese massage of the western part of Hunan province is summarized as four aspects, named "theory, method, recipe and degree". "Theory" refers to the four diagnostic methods and eight principle in terms of diagnosis and treatment and the therapeutic emphasis on the main disorders of organs in children. "Method" refers to promotion and restriction of five elements, meridian tropism in treatment. "Recipe" refers to the selection of acupoints, optimization of therapeutic techniques and the key in the composition of the herbs with different roles considered, named monarch herb, minister herb, assistant herb and guiding herb. "Degree" refers to the strength and intensity of manipulation to ensure the optimal effect. All of the aforementioned reviews provide the reference to theoretic study on this Chinese massage school.

A comparative study on the bone repair effects of two kinds of tissue regeneration membranes / 中国组织工程研究

BACKGROUND: Our previous study confirmed that BTO/P(VDF-TrFE) piezoelectric nanocomposite membrane containing 5%BTO (BaTO3, BTO) nanoparticles could significantly promote bone marrow mesenchymal stem cells (BMSCs) adhesion, growth, osteogenic differentiation and repair of bone defects due to its bionic potential. However, for clinical applications, it is not clear whether there is any difference between the bone repair effect of this material as a guide for tissue regeneration and that of the existing clinically non-degradable membrane products. OBJECTIVE: To compare the effects of BTO/P(VDF-TrFE) piezoelectric nano-composite membrane materials with commercial PTFE membrane in repairing critical-sized defects of SD rat skull. METHODS: BTO/P(VDF-TrFE) piezoelectric nanocomposite membrane containing 5% BTO nanoparticles was prepared by solution casting method. Scanning electron microscope, atomic force microscope and water contact angle measuring instrument were used to observe the surface morphology, measure the surface roughness and surface hydrophilicity and hydrophobicity of the material. In SD rats (purchased from the Laboratory Animal Center, Beijing University Hospital of Stomatology, China), a 5-mm sized full-thick bone defect was made on both sides of the sagittal suture of the skull. The left bone defect was covered with PTFE membrane (control group). The right bone defect was covered with BTO/P(VDF-TrFE) piezoelectric nano-composite membrane (experimental group). At postoperative 4 and 12 weeks, micro-CT and histological methods were used to evaluate the repair of the skull defect in rats. This study was approved by Animal Ethics Committee, Beijing University Hospital of Stomatology. RESULTS AND CONCLUSION: The piezoelectric nanocomposite membrane had smooth and dense surface and BTO nanoparticles were evenly distributed. PTFE membrane was composed of loose coarse fibers. The piezoelectric nanocomposite membrane had lower surface roughness (P<0.001) and higher hydrophilicity (P<0.001) than PTFE membrane. Micro-CT and histological results showed that at 4 weeks after surgery, new bone formation was found in both groups, but new bone formation was more obvious in the center of the defect in the experimental group than in the control group. At 12 weeks after surgery, bone defects healed in both groups, but the maturity of newly formed bone in the experimental group was greater than that in the control group. These results suggest that BTO/P(VDF-TrFE) piezoelectric nanocomposite membrane containing 5%BTO (BaTO3, BTO) nanoparticles can be used as a membrane guiding tissue regeneration.

The measurement accuracy of right coronary artery during coronary angiography at 45Gdegree left oblique position / 实用放射学杂志

Objective To explore the measurement accuracy of right coronary artery during coronary angiography (CAG)at 45Gdegree left oblique position.Methods The images of right coronary artery angiographic view of 45Gdegree left oblique position were divided into nine average areas.The images with marker segment of guiding wire located in the central area (n＝45)or subcentral area (n＝45)of CAG cases were collected retrospectively and randomly.The marker segment was measured by catheter calibration method,and the measure values were compared with the actual length (30 mm).Results A N OVA analysis suggested statistical differences among the three groups (F＝4.59,P＜0.05).By paired comparison,no significant differences were found in measured values between central areas (3 1.1 9± 4.12)mm or subcentral areas (29.55±2.75)mm and the actual length (P＞0.05).Significant differences were found in measured values between central areas and subcentral areas (P＜0.05).The measuring error of subcentral areas (－1.5%)was less than that of central areas (3.9%).Conclusion During CAG at 45Gdegree left oblique position,the values of subcentral area were more accurate than those of central area and the subcentral area was thus regarded as image area with less measurement error in interventional surgery.