ABSTRACT
Purpose To investigate the correlation and clinical value of HBO1 and Ki-67 expression in patients with hepatocelluar carcinoma ( HCC). Methods The expression of HBO1 and Ki-67 in 142 cases of hepatocellular carcinoma tis-sues and corresponding adjacent tissues was detected by immu-nohistochemical EnVision. The correlation of clinical pathologic characteristics and prognosis between them was analyzed. Re-sults The positive rates of HBO1 and Ki-67 in HCC were 69. 0% (98/142) and 55. 6% (79/142), respectively, which was obviously higher than that in para-carcinoma tissues (24.6%,19.7%) with statistically significance (P＜0.05). The expressions of HBO1 and Ki-67 were positively correlated. The expressions of HBO1 and Ki-67 were both related to the tumor size, degree of differentiation, TNM staging and portal thrombosis ( P ＜0. 05 ). Kaplan-Meier univariate statistical a-nalysis showed that the survival time of patients with high HBO1 and Ki-67 expression group was significantly shorter than that of the low expression group (P＜0. 05). Cox multivariate analysis showed that high expression of HBO1 and Ki-67, TNM staging and portal thrombosis were significantly correlated to the progno-sis of patients ( P ＜0. 05 ). Conclusion The expressions of HBO1 and Ki-67 are related to the development of HCC and prognosis. Combined detection of HBO1 and Ki-67 may helpful to judge the malignant degree and prognosis of HCC.