A autonomia do adolescente em relação ao direto de imunização contra infecções sexualmente transmissíveis: revisão bibliográfica / La autonomía de los adolescentes en relación con la inmunización directa contra las infecciones de transmisión sexual: revisión bibliográfica / The autonomy of adolescents in relation to the direct of immunization against sexually transmitted infections: bibliographic review

O presente estudo trata-se de uma análise na literatura sobre o aspecto bioético da autonomia em relação a imunização contra Hepatite B e HPV na adolescência. Foi realizada uma revisão bibliográfica baseada no método prisma onde foram incluídos artigos em português e inglês os quais foram pesquisados nas plataformas Scientific Electronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e National Library of Medicine (PUBMED), utilizando os seguintes descritores Hepatitis B Vaccines, bioethics, Humans. Os resultados demostraram a eficiência dos profissionais de saúde no contato com o indivíduo e o convencimento deste através de um diálogo aberto e criação de vínculos. Evidenciou-se ainda o estudo evidenciou o direito a autonomia progressiva do paciente, no qual este ganha o direito a algumas escolhas como as imunizações de doenças sexualmente transmissíveis, como é o caso da Hepatite B e HPV, no entanto é necessário que o adolescente seja instruído sobre a imunização. Assim sendo, reconhece-se o direito a autonomia progressiva do adolescente, referente a escolha das imunizações contra a Hepatite B e HPV, entretanto, deve-se considerar que estes indivíduos sejam instruídos sobre os benefícios individuais e/ou coletivos da vacinação, contemplados por atividades de educação em saúde por profissionais qualificados, objetivando ampliar a cobertura global de imunização com doenças que caracterizam problemas de saúde pública.

El presente estudio es un análisis de la literatura sobre el aspecto bioético de la autonomía en relación con la inmunización contra la Hepatitis B y el VPH en la adolescencia. Se realizó una revisión bibliográfica basada en el método del prisma, que incluyó artículos en portugués e inglés que fueron buscados en la Biblioteca Científica Electrónica en Línea (SciELO), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) y la Biblioteca Nacional de Medicina (PUBMED), utilizando los siguientes descriptores Vacunas Hepatitis B, bioética, Humanos. Los resultados demostraron la eficiencia de los profesionales de la salud en contactar al individuo y convencerlo a través de un diálogo abierto y creación de vínculos. También se evidenció que el estudio evidenció el derecho del paciente a la autonomía progresiva, en la que adquiere el derecho a algunas opciones como las inmunizaciones de enfermedades de transmisión sexual, como la Hepatitis B y el VPH, sin embargo, es necesario que el adolescente sea educado sobre la inmunización. Por lo tanto, se reconoce el derecho del adolescente a la autonomía progresiva, en cuanto a la elección de las vacunas contra la Hepatitis B y el VPH, sin embargo, se debe considerar que estos individuos sean educados sobre los beneficios individuales y/o colectivos de la vacunación, contemplados por las actividades de educación en salud por profesionales calificados, con el objetivo de ampliar la cobertura mundial de inmunización con enfermedades que caracterizan los problemas de salud pública.

The present study is an analysis of the literature on the bioethical aspect of autonomy in relation to immunization against Hepatitis B and HPV in adolescence. A bibliographic review was carried out based on the prism method, which included articles in Portuguese and English which were searched on the Scientific Electronic Library Online (SCIELO), Latin American and Caribbean Literature on Health Sciences (LILACS) and the National Library of Medicine (PUBMED), using the following descriptors Hepatitis B Vaccines, bioethics, Humans. The results demonstrated the efficiency of health professionals in contacting the individual and convincing him/her through an open dialogue and creation of bonds. It was also evidenced the study evidenced the patient's right to progressive autonomy, in which he gains the right to some choices such as immunizations of sexually transmitted diseases, such as Hepatitis B and HPV, however it is necessary for the adolescent to be educated about immunization. Therefore, the adolescent's right to progressive autonomy is recognized, regarding the choice of immunizations against Hepatitis B and HPV, however, it must be considered that these individuals are instructed on the individual and/or collective benefits of vaccination, contemplated by health education activities by qualified professionals, aiming to expand the global coverage of immunization with diseases that characterize public health problems.

Factores individuales e institucionales asociados a la vacunación contra el virus de la hepatitis B en recién nacidos de hospitales de Lima y Callao

Introducción. La vacunación contra el virus de la hepatitis B (VHB) en recién nacidos es crucial para la prevención de la transmisión perinatal. Objetivo. Determinar factores individuales e institucionales asociados a la vacunación contra el VHB en las 12 y 24 primeras horas de vida. Métodos. Se diseñó un estudio transversal y multicéntrico. Los datos sobre la vacunación fueron recogidos de los padres y de la revisión de reportes. Los datos de los variables individuales de los recién nacidos y madres fueron recogidos de las historias clínicas. Los datos institucionales fueron recogidos de registros de atención inmediata y directamente del personal de inmunizaciones. Resultados. Se incluyó 777 recién nacidos en 10 establecimientos. En el análisis multinivel resultó favorable a la vacunación en las primeras 12 horas, el mayor tiempo de atención en los servicios de inmunizaciones (RP: 1,0; IC95%: 0,99 - 1,01). Para la vacunación dentro de las 24 horas de vida fue favorable la mayor cantidad de personal de enfermería en los servicios de vacunación (RP: 1,02; IC95%: 1,01 - 1,03) y desfavorable la mayor cantidad de partos al día de los establecimientos (RP: 0,99; IC95%: 0,99 - 0,997). No se identificó factores individuales. Conclusión. Factores institucionales, como el tiempo de atención, la cantidad de personal de enfermería y la cantidad de partos, estuvieron asociados con la vacunación contra el VHB en recién nacidos. Se requiere estrategias de mejora como la introducción de la vacunación en la atención inmediata del neonato para la prevención de la transmisión perinatal del VHB.

Introduction. Vaccination against hepatitis B Virus (HBV) in newborns is crucial for the prevention of perinatal transmission. Objective. To determine the individual and institutional factors associated with vaccine for HBV in newborns in the first 12 hours and 24 hours of life. Methods. A cross-sectional, multicenter-design study was conducted in high level public and private hospitals in Lima Metropolitana and Callao. Information on vaccination was obtained through consultations with parents and review of health service reports. Individual variables of the newborns and their mothers were obtained from the medical records of the newborns. Institutional data were collected from immediate care records and from health personnel responsible for the immunization program. Results. The study was conducted in 10 health facilities, including 777 newborns. In the multilevel analysis, the longest care time in the vaccination service was favorable for vaccination within 12 hours of life (PR: 1,0; 95% CI: 0,9995-1,01); while for vaccination within 24 hours of life was favorable the greater number of nursing personnel (RP: 1,02; IC95%: 1,01-1,03) and unfavorable the greater number of deliveries per day in the institution (RP:0,99; IC95%: 0,99-0,997). No individual factors related to vaccination were identified. Conclusions. Institutional factors, such as length of care, number of nursing staff, and number of deliveries, were associated with newborn HBV vaccination. Improvement strategies are required, such as the introduction of vaccination in the immediate care of the newborn for the prevention of perinatal transmission of HBV.

Knowledge level of healthcare professionals regarding hepatitis B immunizatıon of newborns: example of Turkey

SUMMARY OBJECTIVE: The aim of this study was to evaluate healthcare professionals' knowledge level for hepatitis B immunization of term and preterm newborns. METHODS: The study was conducted with 213 midwives, nurses, and physicians between October 2021 and January 2022 in a province of Turkey. RESULTS: Participants had the least knowledge about the management of newborns with low birth weight born to hepatitis B-infected mothers (16%). CONCLUSION: The study revealed some knowledge gaps among healthcare professionals regarding hepatitis B immunization of newborns.

El HeberNasvac®, una opción en el tratamiento de la hepatitis B crónica

Introducción: En Cuba se produce la vacuna HeberNasvac® para el tratamiento de la hepatitis B crónica. Su relevancia radica en lograr resultados de control virológico sostenido en una mayor proporción de pacientes. Objetivo: Evaluar seguridad y efectividad de la vacuna terapéutica HeberNasvac® en el tratamiento de la hepatitis B crónica, en la provincia Camagüey en el periodo comprendido de enero de 2019 a diciembre de 2020. Métodos: Se realizó un estudio cuasi experimental de intervención terapéutica, en pacientes atendidos en la Consulta Provincial de hepatitis virales crónicas. El universo estuvo constituido por 24 pacientes adultos, con carga viral detectable al inicio del estudio. La fuente primaria de la investigación estuvo dada por la historia clínica. Resultados: En el primer ciclo fueron más frecuentes la cefalea y los estornudos; y en el segundo ciclo la fiebre y el malestar general. Al concluir el tratamiento la mayoría mostraron mejoría de resultados de las pruebas de función hepática. Antes del tratamiento el mayor número de pacientes presentó una carga viral detectable por encima de 250 copias/mL y después de haber recibido tratamiento varios de los casos resultaron carga no detectable. El tratamiento se consideró con mediana seguridad en el mayor número de pacientes y la efectividad fue alta. Conclusiones: Se presentaron más eventos adversos en el segundo ciclo del tratamiento. Las pruebas de función hepática mostraron mejoría al concluir tratamiento. La carga viral después del tratamiento presentó un descenso. El tratamiento mostró mediana seguridad y efectividad alta.

Introduction: Cuba produces the HeberNasvac® vaccine for the treatment of chronic hepatitis B. Its relevance lies in achieving sustained virological control results in a greater proportion of patients. Objective: To evaluate the safety and effectiveness of the therapeutic vaccine HeberNasvac® in the treatment of chronic hepatitis B, in the province of Camagüey in the period from January 2019 to December 2020. Methods: A quasi-experimental study of therapeutic intervention was carried out in patients treated at the Provincial Consultation of Chronic Viral Hepatitis. The universe consisted of 24 adult patients, with detectable viral load at the beginning of the study. The primary source of the investigation was given by the medical history. Results: In the first cycle, headache and sneezing were more prevalent; and in the second cycle, fever and general malaise were more prevalent. At the end of the treatment, the majority showed improvement in the results of liver function tests. Before treatment, the largest number of patients had a detectable viral load above 250 copies / mL and after receiving treatment, several of the cases resulted in an undetectable load. The treatment was considered to be of medium safety in the largest number of patients and the effectiveness was high. Conclusions: There were more adverse events in the second cycle of treatment. Liver function tests showed improvement at the end of treatment. The viral load after treatment showed a decrease. The treatment showed medium safety and high effectiveness.

Seroprevalence of hepatitis B, C and D markers in indigenous patients seen at the Native American Outpatient Clinic of Universidade Federal de São Paulo

ABSTRACT Objective To detect and treat cases of viral hepatitis B, C and D in patients seen at the Native American Outpatient Clinic of Universidade Federal de São Paulo. Methods This sample comprised 81 indigenous recruited between 2018 and 2020. Volunteers were aged 7 months to 70 years (mean age of 28±20 years), belonged to 26 ethnic groups spanning the Brazilian territory and answered a questionnaire, which was attached to their medical records. Peripheral blood samples (20mL) were collected, transported to the Clinical Laboratory of Hospital Israelita Albert Einstein, processed, and tested for markers of viral hepatitis B, C and D. Results In this study, 39 (48.1%) individuals were anti-HBs (+) only, 13 (16.0%) individuals were anti-HBs (+) and anti-HBc (+), and 28 (34.6%) individuals were negative for all markers. No anti-HBc IgM+ samples were found. No cases of hepatitis C and D were found. Conclusion This analysis provided evidence of previous infection by the hepatitis B virus. These findings led to prescription of vaccination against hepatitis B to all participants who were negative for all viral hepatitis B markers, given records of prior hepatitis B vaccination were unreliable.

Completude do esquema vacinal contra a hepatite B segundo registros de imunização / Completeness of immunization schedule against hepatitis B according to immunization records

Objetivo: Analisar a completude do esquema vacinal contra hepatite B (recombinante) de adultos em município de Minas Gerais, segundo registros de imunização no Sistema de Informação do Programa Nacional de Imunização (SIPNI). Métodos: Estudo transversal, descritivo e analítico realizado a partir da base de dados do SIPNI, em 2019. Foram analisados 654 registros de pessoas vacinadas contra a hepatite B (recombinante). Resultados: Identificou-se que apenas 10,55% dos vacinados completaram o esquema vacinal contra hepatite B (recombinante). Indivíduos do sexo feminino apresentaram 3,23 vezes mais chances de ter esquema vacinal completo se comparados com o sexo masculino e aqueles com 50 anos e mais têm 2,77 vezes mais chances de ter esquema completo se comparados com indivíduos de 25 a 49 anos. O tempo médio para fechamento do esquema vacinal foi de 244 dias. Conclusão: O presente estudo apontou para uma baixa completude no esquema vacinal contra hepatite B.

Objective: To analyze the completeness of immunization schedule against hepatitis B (recombinant) of adults in the city of Minas Gerais, according to immunization records on the Information System of the National Immunization Program (SIPNI). Methods: Cross-sectional, descriptive and analytical study carried out based on data from the SIPNI, in 2019. There was the analysis of 654 records of individuals vaccinated against hepatitis B (recombinant). Results: Only 10.55% of the vaccinated completed the vaccination against hepatitis B (recombinant). Female subjects had 3.23 times more chances of completing vaccination schedule if compared to males and those aged 50 years or more have 2.77 times more chances of having full immunization schedule if compared to individuals aged from 25 to 49 years. The mean time for completion of the immunization schedule was 244 days. Conclusion: The present study pointed to a low completeness in the immunization schedule against hepatitis B.

Rate of active immune response to hepatitis B vaccine in adult hepatitis B recipients after liver transplantation and its correlation with CD4 level before vaccination / 临床肝胆病杂志

ObjectiveTo investigate the main clinical influencing factors for the rate of active immune response to hepatitis B vaccine in adult hepatitis B recipients after liver transplantation. MethodsAnalysis was performed for the clinical follow-up data of 15 hepatitis B recipients after liver transplantation who received hepatitis B vaccine in Peking University International Hospital from May 2019 to November 2020, and all patients received liver transplantation at least 3 years before and had a CD4 level of 300-800 cells/u before vaccination. Each dose of vaccination was 40 μg recombinant hepatitis B vaccine (Saccharomyces cerevisiae), with a total of 4 injections at 0, 1, 6, and 8 months. Anti-HBs ≥100 mIU/L after four injections which lasted for 12 weeks without attenuation was considered successful response. Pearson correlation analysis and Kendall correlation analysis were used to investigate the correlation between CD4 level before vaccination and vaccine response rate; a linear regression analysis was used to investigate whether CD4 level before vaccination could predict the titer of anti-HBs after active vaccine immunization; a logistic regression analysis was used to investigate whether CD4 level before vaccination could predict vaccine response. ResultsOf all patients at week 12 of monitoring, 6 patients had response, among whom 1 had an anti-HBs level of ＞1000 mIU/L and 5 had an anti-HBs level of ≥100 mIU/L, and the antibody titer did not attenuate till week 16; the response rate of hepatitis B vaccine was 40%. The 6 patients with response had a mean CD4 level of ≥592 cells/u before vaccination, while the 9 patients without response had a mean CD4 level of ≤500 cells/u before vaccination. CD4 level before vaccination was strongly correlated with the response rate of hepatitis B vaccine (Pearson correlation analysis: r=0.767, P=0.001; Kendall correlation: r=0.717, P=0.001). ConclusionCD4 level before vaccination is a key clinical factor affecting the response rate of hepatitis B vaccine after liver transplantation.

Mapeamento da imunização contra o vírus da hepatite B e a estigmatização de doenças virais no contexto odontológico / Mapping immunization against hepatitis B virus and the stigmatization of viral diseases within odontology

Introdução: A AIDS e a Hepatite B são doenças virais de grande impacto epidemiológico e social, que repercutem de maneira negativa em todas as conjunturas, instâncias e práxis da saúde pública mundial. Na perspectiva odontológica, a alta infectividade, a patogenicidade e a estigmatização do vírus da imunodeficiência humana (HIV) e da hepatite B (VHB), além de deixarem os profissionais mais expostos às suas vulnerabilidades laborais, podem fomentar práticas e presunções discriminatórias. Objetivo: A presente tese foi dividida em dois capítulos, com objetivos diferentes. Capítulo 1 - mapear o perfil de imunização dos cirurgiões-dentistas da rede pública de saúde por meio do teste imunocromatográfico Anti-HBsAg e identificar seus fatores associativos. Capítulo 2 - comparar o conhecimento, a presença e a manifestação de atos discriminatórios e estigmatizantes de cirurgiões-dentistas, auxiliares e acadêmicos de Odontologia a respeito das representações sociais do HIV/AIDS e da hepatite B. Metodologia: Tratam-se de dois estudos epidemiológicos transversais quantitativos. Para a condução metodológica do primeiro capítulo, fizeram parte do universo amostral cirurgiões-dentistas da Atenção Primária à Saúde (APS) de 40 municípios pertencentes ao Departamento Regional de Saúde ­ II (DRS-II), do estado de São Paulo. A coleta dos dados foi feita em três etapas: aplicação do inquérito semiestruturado; investigação do protocolo vacinal contra o VHB; e análise da imunização pelo teste rápido imunocromatográfico AntHbsAg. Para o processamento estatístico, foi utilizada a análise bivariada em subsequência à análise de regressão logística binomial. No segundo capítulo, fizeram parte do universo amostral cirurgiões-dentistas e auxiliares em saúde bucal da APS dos 40 municípios da DRS-II e acadêmicos de Odontologia de uma universidade pública. Para a condução do estudo foi construído um instrumento de pesquisa que tinha como objetivo identificar de maneira ampla e objetiva as atitudes e os comportamentos potencialmente profusos de ações discriminantes. Para análise dos dados utilizou-se o Teste Z de proporção para comparação entre os grupos. Resultados: No capítulo 1, do total da amostra (219), 74,9% afirmou ter tomado as três doses da vacina e 35,6% não estava imune contra o VHB. Foram verificadas associações entre a variável dependente e o tempo de trabalho no serviço público; o conhecimento da temática em estudo; o desconhecimento do número de doses da vacina que foram administradas; e ter tomado menos de três doses da vacina. No capítulo 2, participaram da pesquisa 550 sujeitos. Foram verificadas associações significativas no conhecimento dos participantes do estudo sobre o HIV/AIDS e hepatite B, com maior representatividade de cirurgiões-dentistas. Dentre as doenças infecciosas analisadas, foi observado, de modo geral, um maior receio perante o HIV/AIDS. Por outro lado, quando inqueridos sobre o risco de infectividade, houve maior representatividade da hepatite B. Além disso, 30,7% e 42,2% dos indivíduos aceitariam ser atendidos por um profissional com HIV/AIDS e hepatite B, respectivamente, com maiores proporções de recusas pelos auxiliares e acadêmicos. Sobre a existência de distinções nas condutas clínicas de atendimento ao paciente com AIDS e hepatite B, o grupo de auxiliares teve as maiores proporções. Conclusão: No primeiro capítulo, parte dos cirurgiões-dentistas da APS não eram imunes contra o VHB. Já sobre os fatores de risco analisados, foi verificado que o conhecimento, o tempo de trabalho e a completude do esquema vacinal foram influentes para a não imunização. No segundo capítulo, foi possível concluir que o conhecimento sobre a temática ainda é obstáculo a ser enfrentada pelos auxiliares e acadêmicos. Em relação à presença e à manifestação de atitudes discriminatórias e estigmatizantes, foi constatado que elas existem de maneira velada e oculta pelos grupos dos acadêmicos e auxiliares, principalmente em relação ao HIV/AIDS(AU)

Introduction: AIDS and hepatitis B are viral diseases of great epidemiological and social impact. They negatively affect all conjunctures, instances, and praxis of global public health. From the dental perspective, the high infectivity, pathogenicity, and stigmatization of the human immunodeficiency virus (HIV) and hepatitis B virus (HBV) expose professionals to their work vulnerability and may foster discriminatory practices and presumptions. Objective: the main objective was addressed in two chapters, with different purposes. In chapter 1, we aimed to map the immunization profile of dental surgeons in the public health system and to identify its associative factors. To this end, we employed the anti-HBsAg immunochromatographic test. In chapter 2, we aimed to compare the knowledge, presence, and manifestation of discriminatory and stigmatizing acts of dental surgeons, dental assistants, and dental students concerning the social representations of HIV/AIDS and hepatitis B. Methodology: Two quantitative cross-sectional epidemiological studies were conducted. In the first chapter, the sample comprised dental surgeons working at the Primary Health Care (PHC) of 40 municipalities belonging to the Regional Health Department II (DRS-II) of the state of São Paulo. Data collection was performed in three stages: a semistructured interview; an investigation into the vaccine protocol against HBV; and an immunization analysis through the anti-HBsAg immunochromatographic rapid test. A binomial logistic regression analysis and a bivariate analysis provided the statistical data. In the second chapter, the sample comprised dental surgeons and dental assistants working at the PHC of 40 municipalities belonging to the DRS-II and dental students of a pubic university. We built a research instrument to broadly and objectively identify the potentially profuse attitudes and behaviors of discriminating actions. For data analysis, we performed the proportion Z-test to compare groups. Results: In chapter 1, 74.9% of the sample (219) claimed to have taken the three doses of the vaccine, while 35.6% were not immune against HBV. We verified associations between the dependent variable and the working time in the public service, the knowledge about the subject under study, the unawareness of the number of vaccine doses taken, and the fact of having taken less than three doses. In chapter 2, 550 subjects participated in the study. We found significant associations regarding participants' knowledge of HIV/AIDS and hepatitis B, with a greater representation of dental surgeons. Among the diseases investigated, HIV/AIDS raised the greatest concern. On the other hand, concerning the risk of infectivity, hepatitis B had a greater representativeness. In general, 30.7% and 42.2% of participants would accept receiving care from professionals with HIV/AIDS and hepatitis B, respectively; assistants and students had a higher proportion of refusal of care. Dental assistants had greater representativeness regarding distinctions in the clinical conduct of care for patients with AIDS or hepatitis B. Conclusion: In the first chapter, some of the dental surgeons were not immune to HBV. Regarding the risk factors, we verified that the knowledge, the working time, and the completeness of the vaccination schedule affected non-immunization. In the second chapter, we concluded that knowledge about the subject is still an impediment to be faced by dental assistants and students. Regarding the presence and manifestation of discriminatory and stigmatizing behaviors, we verified that they are veiled and hidden by groups of dental students and assistants, especially concerning HIV/AIDS(AU)

Differences in hepatitis B vaccination strategies among children in China and foreign countries / 临床肝胆病杂志

Hepatitis B is still one of the major infectious diseases in China, and hepatitis B vaccination is the most effective method to control the spread of hepatitis B. This article compares and summarizes the similarities and differences in hepatitis B vaccination for children in major authoritative documents from China and foreign countries, elaborates on the issues of hepatitis B vaccination in children with exposure to high risks and failure of vaccination and other issues associated with hepatitis B vaccination in children in China, so as to provide suggestions for clinical practice.

Investigation of hepatitis B virus infection and hepatitis B vaccination coverage in junior middle school children of migrant workers in Pudong New Area of Shanghai / 第二军医大学学报

Objective To investigate the status of hepatitis B virus (HBV) infection and hepatitis B vaccination in junior middle school children of migrant workers in Pudong New Area of Shanghai, so as to provide evidence for prevention and treatment of hepatitis B. Methods A total of 298 children of migrant workers were recruited from junior middle schools of five communities in Pudong New Area, where migrant workers gathered. Questionnaire survey and HBV serological test were conducted. Results The 298 students had a hepatitis B vaccination coverage rate of 70.8% (211/298) and the whole-course vaccination coverage rate of 48.3% (144/298). The vaccination coverage rate of ethnic minority students was significantly lower than that of Han students (P<0.01). The vaccination coverage rate of children whose fathers were private business owners was the highest (P<0.001). The vaccination coverage rate of children whose fathers had junior college or above education background was significantly higher than those whose fathers had a lower one (P<0.01). The positive rates of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus core antibody (HBcAb) in these children were 2.3% (7/298) and 4.7% (14/298), respectively. HBV infected family member was the independent influencing factors for positive HBsAg or HBcAb (P<0.01). HBsAb positive rate was 36.6% (109/298) in these children, with that of ethnic minority students being significantly higher than that of Han students (P<0.05). The proportion of low hepatitis B virus surface antibody (HBsAb) titer (10 mU/mL≤HBsAb<100 mU/mL) in Han students was higher than that of ethnic minority students, while the proportions of normal level (100 mU/mL≤HBsAb<1 000 mU/mL) and high level (HBsAb≥1 000 mU/mL) of ethnic minority students were significantly higher than those of Han students (P<0.05). Conclusion The hepatitis B vaccination coverage rate is relatively low in junior middle school children of migrant workers, and the positive rates of HBsAg and HBcAb are slightly higher, and these children are important targets for hepatitis B prevention and treatment in Shanghai and other megacities in the future. Health management and education of hepatitis B prevention and treatment should be strengthened for migrant workers and their children.

Multivariate analysis of immune effect of hepatitis B vaccination in post-liver transplantation children aged under 5 years old / 国际外科学杂志

Objective To investigate the effect of hepatitis B vaccine immune response after liver transplantation in children under 5 years old and assess the necessity of multiple vaccination.Methods A retrospective collection of children who had liver transplantation from February 2014 to December 2018 in the same liver transplantation group in the Department of General Surgery,Beijing Friendship Hospital,Capital Medical University were analyzed.In accordance with the requirements of the doctor,170 children under 5 years old injected with over 4 doses were enrolled,including 75 males and 95 females,aged from 4 months to 5 years old.After every dose of vaccination,the blood were collected to detect hepatitis B following regular review in liver transplantation clinic,observe the effect of HBsAb (hepatitis B surface antibody) after postoperative hepatitis B vaccination.Count data were represented by cases and percentage (％),and comparison between groups were analyzed by chi-square test.Results After the first course of treatment,in total children under 5 years old who completed the first course of treatment,121 cases got successful immune responses (HBsAb ≥ 100 IU/L) and 49 cases got the responses failure (HBsAb ＜ 100 IU/L).After the second course of treatment,29 cases got successful immune responses,and only 20 cases finally failed to response (HBsAb ＜ 10 IU/L) to 8 injections namely two courses.The factors affecting the immune effect of hepatitis B vaccination were not related to gender,primary disease,liver feeding mode,and postoperative vaccination time,and were related to age,place of residence,and preoperative level of HBsAb titer (100 IU/L).The immune responses rate of children averagly aged over 2 years old was significantly higher than that of children under 1 year old after the first course of postoperative vaccination.Children with preoperative hepatitis B vaccination and ＞ 100 IU/L anti-HBs titer had a higher immune response rate after the first course of postoperative vaccination (84.72％),and the immune response rate of children with anti-HBs titers ＜ 100 IU/L after the first course of hepatitis B vaccine was slightly lower(60.71％).Conclusions Most post-liver transplantation children can obtain protective antibodies to prevent re-infection of hepatitis B virus by inoculation with hepatitis B vaccine.Multiple inoculation can effectively induce hepatitis B antibody production and improve immune response level economically.The hepatitis B vaccination proved to be indispensable and is one of the current methods promoted and applied to post-liver transplantation.

Multivariate analysis of immune effect of hepatitis B vaccination in post-liver transplantation children aged under 5 years old / 国际外科学杂志

Objective@#To investigate the effect of hepatitis B vaccine immune response after liver transplantation in children under 5 years old and assess the necessity of multiple vaccination.@*Methods@#A retrospective collection of children who had liver transplantation from February 2014 to December 2018 in the same liver transplantation group in the Department of General Surgery, Beijing Friendship Hospital, Capital Medical University were analyzed. In accordance with the requirements of the doctor, 170 children under 5 years old injected with over 4 doses were enrolled, including 75 males and 95 females, aged from 4 months to 5 years old. After every dose of vaccination, the blood were collected to detect hepatitis B following regular review in liver transplantation clinic, observe the effect of HBsAb (hepatitis B surface antibody) after postoperative hepatitis B vaccination.Count data were represented by cases and percentage (%), and comparison between groups were analyzed by chi-square test.@*Results@#After the first course of treatment, in total children under 5 years old who completed the first course of treatment, 121 cases got successful immune responses(HBsAb≥100 IU/L) and 49 cases got the responses failure (HBsAb<100 IU/L). After the second course of treatment, 29 cases got successful immune responses, and only 20 cases finally failed to response (HBsAb<10 IU/L)to 8 injections namely two courses. The factors affecting the immune effect of hepatitis B vaccination were not related to gender, primary disease, liver feeding mode, and postoperative vaccination time, and were related to age, place of residence, and preoperative level of HBsAb titer (100 IU/L). The immune responses rate of children averagly aged over 2 years old was significantly higher than that of children under 1 year old after the first course of postoperative vaccination. Children with preoperative hepatitis B vaccination and >100 IU/L anti-HBs titer had a higher immune response rate after the first course of postoperative vaccination (84.72%), and the immune response rate of children with anti-HBs titers <100 IU/L after the first course of hepatitis B vaccine was slightly lower(60.71%).@*Conclusions@#Most post-liver transplantation children can obtain protective antibodies to prevent re-infection of hepatitis B virus by inoculation with hepatitis B vaccine. Multiple inoculation can effectively induce hepatitis B antibody production and improve immune response level economically. The hepatitis B vaccination proved to be indispensable and is one of the current methods promoted and applied to post-liver transplantation.

Comments on 2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission / 中华肝脏病杂志

Recently, the Society of Infectious Diseases of Chinese Medical Association and Chinese GRADE Center jointly released the "2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission" . We concerned several issues in the Guideline, including the improper citation of some references, no recommendations for some key strategies for the prevention of hepatitis B virus mother-to-child transmission, insufficient or even lack of evidence for some recommendations and others. Based on the principle of academic contention, we present in this article our comments on the Guideline to discuss these issues with the Guideline’s authors and readers.

Post-vaccination anti-HBs testing among healthcare workers: More economical than post-exposure management for Hepatitis B / Teste anti-HBs pós-vacinação entre trabalhadores da saúde: mais econômico que manejo pós-exposição para Hepatite B / Pruebas anti-HBs post-vacunación entre los trabajadores de la salud: más económico que el manejo post-exposición para la Hepatitis B

Objective: to compare the direct cost, from the perspective of the Unified Health System, of assessing the post-vaccination serological status with post-exposure management for hepatitis B among health care workers exposed to biological material. Method: cross-sectional study and cost-related, based on accident data recorded in the System of Information on Disease Notification between 2006 and 2016, where three post-exposure and one pre-exposure management scenarios were evaluated: A) accidents among vaccinated workers with positive and negative serological status tests for hepatitis B, exposed to known and unknown source-person; B) handling unvaccinated workers exposed to a known and unknown source-person; C) managing vaccinated workers and unknown serological status for hepatitis B and D) cost of the pre-exposure post-vaccination test. Accidents were assessed and the direct cost was calculated using the decision tree model. Results: scenarios where workers did not have protective titles after vaccination or were unaware of the serological status and were exposed to a positive or unknown source-person for hepatitis B. Conclusion: the direct cost of hepatitis B prophylaxis, including confirmation of serological status after vaccination would be more economical for the health system.

Objetivo: comparar o custo direto, sob a perspectiva do Sistema Único de Saúde, da avaliação do status sorológico pós-vacinação com o manejo pós-exposição para hepatite B entre trabalhadores da área da saúde expostos ao material biológico. Método: estudo transversal e de custo, realizado a partir dos dados de acidentes registrados no Sistema de Informação de Agravos de Notificação entre 2006 e 2016, em que foram avaliados três cenários de manejo pós-exposição e um de pré-exposição: A) acidentes entre trabalhadores vacinados com status sorológico positivo e negativo para hepatite B, expostos à pessoa-fonte conhecida e desconhecida; B) manejo dos trabalhadores não vacinados expostos à pessoa-fonte conhecida e desconhecida; C) manejo dos trabalhadores vacinados e status sorológico desconhecido para hepatite B e D) custo do teste pós vacinação pré-exposição. Os acidentes foram avaliados e o custo direto foi calculado utilizando o modelo árvore de decisão. Resultados: apresentaram maior custo os cenários em que os trabalhadores não possuíam títulos protetores após a vacinação ou desconheciam o status sorológico e foram expostos à pessoa-fonte positivo ou desconhecida para hepatite B. Conclusão: o custo direto da profilaxia para hepatite B, incluindo a confirmação do status sorológico após vacinação seria mais econômico para o sistema de saúde.

Objetivo: comparar el costo directo, desde la perspectiva del Sistema Único de Salud, de la evaluación del status serológico post-vacunación con el manejo post-exposición para la hepatitis B entre los trabajadores de la salud expuestos a material biológico. Método: estudio transversal y de costos, basado en datos de accidentes registrados en el Sistema de Información de Enfermedades Notificables entre 2006 y 2016, en el que se evaluaron tres escenarios de gestión posteriores a la exposición y uno previo a la exposición: A) accidentes entre trabajadores vacunados con status serológico positivo y negativo para hepatitis B, expuestos a una fuente de origen conocida y desconocida; B) manejo de trabajadores no vacunados expuestos a una fuente conocida y desconocida; C) manejo de trabajadores vacunados y estado serológico desconocido para hepatitis B y D) costo de la prueba de pre-exposición post-vacunación. Se evaluaron los accidentes y se calculó el costo directo utilizando el modelo de árbol de decisión. Resultados: los escenarios en los que los trabajadores no tenían títulos de protección después de la vacunación o desconocían el status serológico y estaban expuestos a una persona fuente positiva o desconocida para la hepatitis B reflejaron un costo más alto. Conclusión: el costo directo de la profilaxis para la hepatitis B, incluida la confirmación del status serológico después de la vacunación sería más económico para el sistema de salud.

Factores asociados a respuesta inadecuada a la vacuna de hepatitis B en pacientes con VIH

Objetivo: Establecer la asociación entre la edad, sexo, Índice de masa corporal, consumo de bebidas alcohólicas y consumo de cigarrillos con la respuesta inadecuada a la vacuna contra la Hepatitis B, en los pacientes con infección por VIH que fueron atendidos en la Unidad Clínica de Enfermedades Infecciosas y Tropicales del Hospital Regional Docente de Trujillo - Perú, entre 2014-2016. Materiales y métodos: Se realizó un estudio observacional, retrospectivo, de corte transversal, tipo casos y controles. Resultados: De los pacientes vacunados se encontró que la edad ≥ 50 años; con OR=3,4 y el CD4<200, con OR=35,0, son los factores de riesgo para la respuesta inadecuada a la vacuna contra hepatitis B. Conclusiones: Existe asociación entre el recuento de células CD4 <200 y la edad mayor de 50 años con una respuesta Inadecuada a la vacunación contra hepatitis B en pacientes infectados por VIH en el Hospital Regional Docente de Trujillo.

Objective: To establish the relationship among age, sex, body mass index, consumption of alcoholic beverages and cigarettes with the inadequate response to the vaccine against Hepatitis B in patients with HIV infection who were treated in the Clinical Unit of Infectious and Tropical Diseases of the Regional Hospital of Trujillo - Peru, from 2014 to 2015. Materials and methods: The study was observational, retrospective, cross-sectional, type cases and controls. Results: In the vaccinated patients, it was found that the age ≥ 50 years old; with OR = 3.4 and CD4 <200, with OR = 35.0, are the risk factors to get the inadequate response to the vaccine against Hepatitis B. Conclusions: There is a relationship between the re-count of cells CD4 <200 and the age over 50 years old with an Inadequate response to the vaccination against hepatitis B in HIV-infected patients in the Regional Hospital of Trujillo.

Conhecimento sobre situação vacinal e perfil de imunoproteção para hepatite B de trabalhadores da assistência hospitalar / Vacinal situation knowledge and Hepatitis B improvement profile of hospital assistance workers / Conocimiento sobre situación vacunal y perfil de inmunoprotección para Hepatitis B de trabajadores de la asistencia hospitalaria

Justificativa e Objetivos: Hepatite B é infecção viral universalmente prevalente e considerada a doença ocupacional infecciosa mais importante entre os profissionais de saúde, e o trabalhador de Enfermagem, por desenvolver ações invasivas em quantidade e frequência intensas, constitui grupo de extrema vulnerabilidade. Imunidade obtida por vacinação constitui estratégia preventiva eficaz, entretanto, cerca de 10% dos vacinados não alcançam títulos protetores de anticorpos, sendo necessário teste sorológico para confirmar imunidade. O objetivo deste estudo foi investigar o conhecimento da equipe de enfermagem sobre situação vacinale perfil deimunoproteção para hepatite B. Métodos: Estudo epidemiológico, analítico, com 70 trabalhadores de um hospital público de referência regional no Estado da Paraíba. Após consentimento, foram submetidos à entrevista, coleta de sangue e testes sorológicos para detecção dos marcadores HBsAg e anti-HBs, em duplicata, por Eletroquimioluminescência. Os dados coletados foram processados no SPSS versão 22.0 e analisados por estatística descritiva. Resultados: A maioria dos participantes é do sexo feminino (85,7%), com média de idade de 33,4 anos e nível médio de escolaridade (75,7%). Sobre a situação vacinal, 65,7% declararam possuírem esquema completo e 12,9% não lembravam/não sabiam se já haviam recebido imunobiológico. Sobre o teste para verificação do status imunológico, 25,7% informaram desconhecerem a existência de teste específico para tal detecção. Houve associação significativa entre categoria profissional e conhecimento sobre o Anti-HBs. Conclusão: O desconhecimento dos trabalhadores de enfermagem sobre seu status vacinal e imunológico os colocam em vulnerabilidade constante para a hepatite B, sinalizando a urgência de atitudes institucionais protetivas para este público.(AU)

Background and Objectives: Hepatitis B is an universally prevalent viral infection, it is considered the most important infectious occupational disease. Immunity obtained through vaccination is an effective preventive strategy, however, about 10% of vaccinees do not achieve protective antibody titers, requiring serological test to confirm immunity. The objective of this study was to investigate the knowledge of the nursing staff about the vaccination situation and immunoprotein profile to hepatites B. Methods: It is an epidemiological, analytical, conducted with 70 workers of a public hospital of regional reference in the State of Paraíba. After consent, they were submitted to the interview, blood collection and serological tests for the detection of HBsAg and anti-HBs markers, in duplicate, by Electrochemiluminescence. The data collected were processed using the SPSS version 22.0 and analyzed using descriptive statistics. Results: Most participants were women (85.7%), with a mean age of 33.4 years and a high school degree (75.7%). About vaccination status, 65.7% reported having complete scheme and 73.9% had blood test with 18.2% of non-seroconversion of them. Regarding the test for immunological status verification, 25.7% reported not knowing the existence of a specific test for such detection. There was a significant association between professional category and knowledge about Anti-HBs. Conclusion: There was a high percentage of non-seroconversion among nursing workers, which, concomitant with the lack of knowledge about their immunological status, made them vulnerable to the disease.(AU)

Justificación y objetivos: La Hepatitis B es una infección viral universalmente prevalente y considerada la enfermedad ocupacional infecciosa más importante entre los profesionales de la salud, y el trabajador de Enfermería, por desarrollar acciones invasivas en cantidad y frecuencia intensas, constituye un grupo de extrema vulnerabilidad. La inmunidad obtenida por vacunación constituye una estrategia preventiva eficaz, mientras que aproximadamente el 10% de los vacunados no alcanzan títulos protectores de anticuerpos, siendo necesario un análisis serológico para confirmar la inmunidad. El objetivo de este estudio fue investigar el conocimiento de personal del equipo de enfermería sobre situación vacunal y perfil de inmunoproteción contra lahepatitis B. Métodos: Estudio epidemiológico, analítico, con 70 trabajadores de un hospital público de referencia regional en el Estado de Paraíba. Después del consentimiento, fueron sometidos a la entrevista, recolección de sangre y pruebas serológicas para detección de los marcadores HBsAg y anti-HBs, en duplicado, por Electroquimioluminescencia. Los datos recopilados se procesaron en el SPSS versión 22.0 y se analizaron por estadística descriptiva. Resultados: La mayoría de los participantes es del sexo femenino (85,7%), con promedio de edad de 33,4 años y con nivel medio de escolaridad (75,7%). En cuanto a la situación vacunal, el 65,7% declaró poseer un esquema completo y el 73,9% hizo una prueba sanguínea, con un 18,2% de no seroconversión. Con respecto a la prueba para verificación del estado inmunológico, el 25,7% informó desconocer la existencia de una prueba específica para tal detección. Hubo asociación significativa entre categoría profesional y conocimiento sobre el anti-HBs. Conclusión: Se verificó alto porcentaje de no seroconversión entre los trabajadores de enfermería, situación que, concomitante al desconocimiento sobre su status inmunológico, los colocan vulnerables a la enfermedad.(AU)

Cumplimiento de la vacunación contra el virus de la hepatitis b en recién nacidos de Lima y Callao / Compliance of hepatitis-b virus vaccination in newborns in Lima and Callao

RESUMEN El objetivo del estudio fue determinar el cumplimiento de la vacunación contra el virus de la hepatitis B (VHB) en recién nacidos de Lima y Callao. Estudio de diseño descriptivo, transversal y multicéntrico, realizado en hospitales de alto nivel, públicos y privados. La información sobre la vacunación corresponde a recién nacidos durante una semana del 2015, y fue obtenida mediante consultas a los padres y revisión de reporte de los servicios de salud. El estudio se realizó en 12 establecimientos de salud incluyéndose a 935 madres y recién nacidos. La cobertura de vacunación dentro de las 24 horas de vida fue de 85,1% según el reporte de padres y 88,7% según el reporte de los servicios de salud. Se concluye que la cobertura la vacunación contra el VHB en recién nacidos dentro de las 24 horas de vida fue importante, pero aún alejada de metas ideales propuestas por el Ministerio de Salud y la Organización Mundial de la Salud.

ABSTRACT The objective of the study was to determine compliance with hepatitis-B virus (HBV) in newborns in Lima and Callao. A descriptive, cross-sectional, multicenter-design study was conducted in high level public and private hospitals. Information on vaccination corresponds to newborns during one week of 2015 and was obtained through consultations with parents and review of health service reports. The study was conducted in 12 health facilities including 935 mothers and newborns. Vaccination coverage within 24 hours of life was 85.1%, according to the parents' report; and 88.7%, according to the health services' report. It is concluded that the coverage of HBV vaccination in newborns within 24 hours of life was important, but still far from the ideal goals proposed by the Ministry of Health and the World Health Organization.

Getting to zero mother-to-child transmission of hepatitis B virus: dream and challenge / 中华肝脏病杂志

To eliminate viral hepatitis as a public health threat, the World Health Organization has set the ambitious goal of reducing the prevalence of hepatitis B surface antigen (HBsAg) in children to 0.1% by 2030, and the key to this grand goal is cutting off hepatitis B virus (HBV) transmission from mother-to-child. Previously, national and international guidelines for the management of chronic hepatitis B recommended the use of hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) or combination of any in neonates and antiviral drugs for pregnant women with high viral load in late pregnancy. However, a recent study in Thailand found that the addition of antiviral drugs in pregnant women with high viral load in the third trimester did not significantly lower the incidence of mother-to-child HBV transmission, but no case of chronic HBV infection was seen with strict standards hepatitis B vaccine and HBIG combined immunoprophylaxis and the use of tenofovir disoproxil in pregnant women with high viral load in the third trimester. In addition, the incidence of mother –to- child transmission of HBV in the antiviral group was 0, while the incidence of HBV transmission in the placebo group was 2%. Therefore, it is not possible to deny the efficacy of adding antiviral drugs in treating pregnant women with high viral load in the third trimester with combined immunoprophylaxis. There is an urgent need for more real-world studies in clinical practice to further reveal the principles and existing problems of mother- to- child transmission of HBV.

Hepatite B e Exposição Ocupacional no Cenário Odontológico. A Valoração do Saber e das Atitudes dos Profissionais / Hepatitis B and occupational Exposure in the Dental Setting. The Valuation of the Knowledge and Professionals Attitudes

A Hepatite B é uma doença pandemica e infecciosa de grande impacto à saúde pública, visto sua alta infectividade e elevados índices de morbidade e mortalidade. O presente estudo teve como objetivo avaliar o conhecimento dos cirurgiões-dentistas sobre o tema hepatite B e as suas atitudes frente aos acidentes ocupacionais. Trata-se de um estudo epidemilógico exploratório, transversal, quantitativo, realizado com cirurgiões-dentistas da rede pública nos níveis de atenção primária e secundária de três municípios do Estado de São Paulo. Para a coleta dos dados foi elaborado um inquérito semiestruturado, exclusivamente, para este estudo. Os dados foram procesados e tabulados com auxílio do pacote estatístico Epi Info 7.1. Do total de 133 profissionais cadastrados, obteve-se participação de 101 (75,96%) cirurgiões-dentistas. Verificou-se que, embora grande parte dos participantes afirmassem ter conhecimento sobre hepatite B (69,31%), apenas metade deles acertou o agente etiológico da doença. Em relação à vacinação, 91,1% diseram ter tomado as 3 doses da vacina, entretanto, somente 50% dos mesmos garantiram estarem imunizados contra o vírus. Sobre os acidentes, a maioria dos incidentes ocorreram apenas uma vez (68,75%) e a agulha da seringa carpule (56,25%) foi o principal agente causador do incidente. Além do mais, dentre os cirugiões-dentistas que já se acidentaram, os quais os pacientes se recusaram realizar os exames de comprovação imunológica, não fizeram as medidas profiláticas pós-exposição. O conhecimento dos cirugiões-dentistas sobre o tema hepatite B se mostra como uma questão, que ainda apresenta falhas, e as medidas protetivas, que devem ser tomadas após acidentes ocupacionais foram totalmente negligenciadas. (AU).

Hepatitis B is a pandemic and infectious disease with a great public health impact due to its high infectivity and high morbidity and mortality rates. This study aimed to evaluate the knowledge of dentists on the topic regarding hepatitis B and their attitudes towards occupational accidents. This is a quantitative cross-sectional exploratory epidemiological study, carried out with dental surgeons of the public network at the primary and secondary care levels from three municipalities in the State of São Paulo. For data collection, a semi-structured survey was designed exclusively for this study. The data were processed and tabulated using the Epi Info 7.1 statistical package. Ou of the total of 133 registered professionals, 101 (75.96%) dentists participated. It was found that, although a large part of the participants claimed to have knowledge about hepatitis B (69.31%), only half of them agreed on the etiological agent of the disease. Regarding vaccination, 91.1% said they had taken all three doses of the vaccine, however, only 50% of them had been immunized against the virus. About the accidents, most incidents occurred only once (68.75%) and the carpule syringe needle (56.25%) was the main causative agent of the incident. In addition, among those dental surgeries who have already experienced accidents, when the patients refused to perform the immunological tests, they did not take the prophylactic measures after exposure. The knowledge of dentists on the topic of hepatitis B is an issue that still presents flaws, and the protective measures that must be taken after occupational accidents have been totally neglected. (AU).

Análise do perfil sociodemográfico de notificados para hepatite B e imunização contra a doença / Análisis sociodemográfico del reportado hepatitis B y la inmunización contra la enfermedad / Sociodemographic analysis of reported hepatitis B and immunization against the disease

Objective: To analyze the socio-demographic profile of reported hepatitis B and immunization against the disease. Methods: Study Hepatitis B notification data in the surveillance of a Minas Gerais’ municipality, from 2007 to 2015, conducted at the Labor Education Program for Health descriptive and analytical statistics, with significance level of p < 0.05. Results: 132 cases and two deaths were notified. The age of the reported cases ranged from zero to 87 years, average 35.8 (± 14.0) years. More frequently for men (52.3%) and with low education (64.8%). Most of them did not vaccinate (81.8%) and had positive result of HSBsAg serology (90.1%); immunization was not linked to the socio-demographic profile (p > 0.05). Conclusion: Age, education and gender were not associated with immunization, vaccination schedule and the HSBsAg test. The absence of vaccination among the notified suggests need for health education among the population, orienting the possibility of protection by immunization.

Objetivo: Analisar o perfil sociodemográfico dos notificados para hepatite B e a imunização contra a doença. Métodos: Estudo com dados de notificação de hepatite B na vigilância epidemiológica do município de Minas Gerais, entre 2007 a 2015, conduzido no Programa de Educação pelo Trabalho para a Saúde. Estatística descritiva e analítica, com nível de significância p < 0,05. Resultados: Notificaram-se 132 casos e dois óbitos. A idade dos notificados variou de zero a 87 anos, média de 35,8 (± 14,0) anos. Maior frequência para homens (52,3%) e baixa escolaridade (64,8%). A maioria não vacinou (81,8%) e teve resultado da sorologia HSBsAg positivo (90,1%); a imunização não se associou ao perfil sociodemográfico (p > 0,05). Conclusão: Idade, escolaridade e sexo não foram associados à imunização, ao esquema vacinal ou ao teste HSBsAg. A ausência de vacinação entre os notificados sugere a necessidade de educação em saúde junto à população, orientando-a sobre possibilidade de proteção pela imunização.

Objetivo: Analizar el perfil sociodemográfico reportado de hepatitis B y la inmunización contra la enfermedad. Métodos: Estudio de datos de notificación de la hepatitis B en la vigilancia del municipio de Minas Gerais, de 2007 a 2015, realizadas en el Programa de Educación para el Trabajo de estadística descriptiva y analítica de la Salud, con un nivel de significación de p<0,05. Resultados: 132 casos fueron notificados; dos muertes. La edad del reportado varió de cero a 87 años, con una media de 35,8 (± 14,0) años. Con mayor frecuencia entre los hombres (52,3%) y baja educación (64,8%). La mayoría no vacunados (81,8%) y tuvo resultado positivo de HSBsAg serología (90,1%); la inmunización no vinculado al perfil sociodemográfico (p > 0,05). Conclusión: La edad, la educación y el sexo no se asociaron con la inmunización, calendario de vacunación y la prueba HSBsAg. La ausencia de vacunación entre los notificados sugiere la necesidad de educación para la salud entre la población, orientando la posibilidad de protección mediante la vacunación.