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Objective To observe the change of results of lipoprotein-associated phospholipase A2 (Lp-PLA2) ,homocysteine (Hcy ) ,high-sensitivity C-reactive protein (hs-CRP ) ,lipids and other indicators in the patients with normal group ,primary hypertension group ,type H hypertension group and type H hypertension ischemic stroke group ,and search the relationship between LP-PLA2 and type H-hypertension ischemic stroke .Methods From January 2015 to June 2017 ,continuous selected 103 patients with type H hypertension ischemic stroke group ,124 patients with type H hypertension group ,80 patients with primary hypertension group and 50 patients with healthy controls as normal group .Analyzed level of Lp-PLA2 ,Hcy ,hs-CRP and lipids in serum ,compared the difference with each group .A binary Logistic regression analysis was used to an-alyze its correlation with ischemic stroke .Results The serum concentration of total cholesterol(TC) ,low-den-sity lipoproteincholesterol(LDL-C) ,LP-PLA2 in type H hypertension group and type H hypertension ischemic stroke group was higher than primary hypertension group and normal group ,the difference was statistically significant(P＜0 .05) .The serum concentration of triglyceride (TG) in type H hypertension ischemic stroke group was higher than primary hypertension group and normal group ,the difference was statistically signifi- cant(P＜0 .05) .The serum concentration of Hcy in primary hypertension group ,type H hypertension group and type H hypertension ischemic stroke group was higher than normal group ,the difference was statistically significant(P＜0 .05) ;The serum concentration of Hcy in type H hypertension group and type H hypertension ischemic stroke group was higher than primary hypertension group ,the difference was statistically significant (P＜ 0 .05) ;The serum concentration of Hcy ,LP-PLA2 in type H hypertension ischemic stroke group was higher than type H hypertension group ,the difference was statistically significant (P＜0 .05) .The serum con-centration of hs-CRP in type H hypertension group was higher than primary hypertension group and normal group ,the difference was statistically significant (P＜0 .05) ;The serum concentration of hs-CRP in type H hy-pertension ischemic stroke group was higher than type H hypertension group ,primary hypertension group and normal group ,the difference was statistically significant (P＜0 .05) .Two element Logistic regression analysis , Lp-PLA2 were significantly related to type H hypertension ischemic stroke ( SE ＝ 0 .013 ,P ＜ 0 .05 ) . Conclusion LP-PLA2 is an inflammatory biomarker and it is closely related to the occurrence and develop-ment of type H hypertension ischemic stroke .
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Objective]The article summarizes the H-hypertension's clinical experience by professor He Jia. [Methods]From following professor He Jia clinical studies, summarize professor He Jia from different ages, the treatment by applying the method of tonifying qi by stasis H-hypertension qi deficiency blood stasis syndrome differentiation thinking and clinical experience, and for proven cases.[Result]The professor He Jia considers the method of Buqi Zhuyu as the basic therapeutic principle, with pathogenesis of qi deficiency and blood stasis in the collaterals. And also to make up for points and syndromes differentiation from youthes and older, in the young and middle-aged people and see blood stasis into collaterals, the treatment of blood stasis by the main,the old people see more Qi deficiency into the network, to make up for the deficiency of Qi.Her clinical medicine is characterized in paying equal attention to the Qi and blood, Buqi Zhuyu, using opportunely insect medicine,Soufeng Tongluo,using the mineral medicine, Ziyin Qianyang along with the disease change, with good effect.[Conclusion]Professor He Jia for H-hypertension treatment of qi deficiency blood stasis unique insights, obtains good effect, often with fellow mutual information.
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Introducción: la hipertensión arterial es una condición clínica multifactorial, caracterizada por la elevación de la presión arterial sistólica o diastólica, establecida como un factor de riesgo importante en la aparición de enfermedades cardiovasculares. Objetivos: determinar los niveles séricos de IFN-γ, TNF-α y proteína C reactiva, relacionándolos con la hipertensión arterial en pacientes que asisten a la E.S.E. Imsalud-Unidad Materno Infantil la Libertad (Cúcuta, Colombia). Materiales y métodos: se realizó un estudio descriptivo, correlacional en individuos hipertensos y controles sanos seleccionados mediante encuesta estructurada. Los niveles séricos del IFN-γ y el TNF-α fueron analizados por ELISA y los de la proteína C reactiva ultrasensible por inmunoturbimetría. Resultados: el 52,8% y el 29,3% de los hipertensos presentaron concentraciones moderadamente altas de IFN-γ y TNF-α respectivamente. De acuerdo a los niveles séricos de proteína C reactiva ultrasensible, el 81,2% de los hipertensos se ubicaron en riesgo cardiovascular bajo, el 6,2% en medio y el 12,5% en alto. Conclusiones: los niveles elevados de IFN-γ en los pacientes hipertensos respecto a los controles sugierenque esta citoquina puede ser considerada un marcador útil como herramienta de evaluación del pronóstico de desarrollo de complicaciones cardiovasculares. Aunque el TNF-α no se encontró aumentado en los pacientes hipertensos, podría ser empleado en aquellos con difícil control de la enfermedad o en quienes no han iniciado el tratamiento antihipertensivo. La proteína C reactiva ultrasensible se reitera como un marcador útil en la estratificación de los niveles de riesgo en los hipertensos, abarcando desde bajo hasta alto de afectación cardiovascular.
Introduction: hypertension is a multifactorial clinical condition characterized by elevated systolic or diastolic blood pressure that it is establishing itself as a major risk factor in the onset of cardiovascular disease. Objectives: To determine serum levels of IFN-γ, TNF-α and C-reactive protein, relating to hypertension in patients attending the E.S.E. Imsalud - Unidad Materno Infantil La Libertad (Cucuta, Colombia). Material and methods: A correlational descriptive study was realized in hypertensive individuals and healthy controls selected through structured survey. Serum levels of IFN-γ and TNF-α were analyzed by ELISA and high-sensitivity C-reactive protein levels by turbidimetric immunoassays. Results: The 52.8% and 29.3% of hypertensive subjects had moderately high concentrations of IFN-γ and TNF-α, respectively. According to serum levels of high-sensitivity C-reactive protein, 81.2% of hypertensive stood at low cardiovascular risk, 6.2% on average, and 12.5% at high risk. Conclusions: Elevated levels of IFN-γ found in hypertensive patients respect to controls, suggest that this cytokine could be consider as a viable marker as a valuable tool in forecasting the development of cardiovascularcomplications. Although TNF-α not increased in hypertensive patients, could be used in those with difficult disease control or who have not initiated antihypertensive treatment. The high-sensitivity C-reactive protein can be reiterate as a marker useful in the stratification of the levels of risk in hypertensivepatients, ranging from low to high risk of cardiovascular involvement.
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Humans , C-Reactive Protein , Cardiovascular Diseases , Hypertension , Interferon-gamma , Tumor Necrosis Factor-alphaABSTRACT
Objective To systematically evaluate the effectiveness and safety of renal sympathetic denervation (RSD) for treatment of patients with resistant hypertension.Methods English and Chinese literatures of controlled clinical trials on RSD in treatment of resistant hypertension were searched from the Cochrane Library,PubMed,Web of Science,Wanfang Database and CNKI up to February 2013.Metaanalysis was performed with the selected studies by using software Rev.Man 5.0.Results Seven studies involving 354 cases with RSD and 146 controls were included for analysis.Compared with control group,RSD significantly lower both systolic and diastolic blood pressure in patients with resistant hypertension (systolic,1 month:MD =-18.04,95％ CI:-19.94--16.14,P ＜0.01; 3 months:MD =0.01,95％CI:-28.10--17.98,P＜0.01; 6 months:MD=-25.59,95％CI:-34.08--17.11,P＜0.01; diastolic,1 month:MD=-7.53,95％ CI:-8.60--6.45,P＜0.01; 3 months:MD =0.01,95％CI:-12.5--4.47,P ＜ 0.01; 6 months:MD =-10.54,95％ CI:-16.44--4.63,P =0.000 5).In addition,there was no significant difference in adverse reactions between RSD treatment group and control group (OR =1.13,95 ％ CI:0.34-3.76,P =0.84).Conclusions Renal sympathetic denervation can effectively reduce blood pressure in patients with resistant hypertension 1-6 months postoperatively,without increase of adverse reactions.The long-term efficacy and safety need to be further observed.
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Spontaneous intracerebral hemorrhage is one of the most devastating forms of cerebrovascular disease, and is most frequently caused by hypertension in the distribution of the perforating arteries. Generally, hypertensive intracerebral hemorrhage is usually a single lesion, and recurrent intracerebral hemorrhage due to hypertension is not a rare condition. But multiple simultaneous intracerebral hemorrhage caused by hypertension is very rare. The authors report 4 cases of multiple hypertensive intracerebral hemorrhage. This represents 0.77% of total 514 hypertensive intracerebral hemorrhages treated between January, 1994 and December, 1997 in our institution. All patients had chronic history of hypertension, and the locations of the hematomas were as follows: both basal ganglia in two cases, right basal ganglia and left thalamus in one case, cerebellum and left parietal lobe in one case. Two cases were treated by surgical evacuation of hematoma and remaining two were treated by conservative management. The results of treatment were poor in all patients.