Analysis of factors influencing treatment outcomes of halo nevus / 中华皮肤科杂志

Objective To investigate clinical characteristics of halo nevus,and to explore factors influencing its treatment outcome.Methods A prospective study was conducted in 250 patients with halo nevus from February 2016 to November 2016 to analyze the factors influencing treatment outcomes.Results There were a total of 293 lesions in the 250 patients,including 219 (87.6％) patients with solitary lesions and 31 (12.4％) with multiple lesions.Among these lesions,154 (52.6％) occurred on the trunk,and 127 (43.3％) occurred on the face and neck.The diameters of the lesions ranged from 5 mm to 20 mm.Not all the halo nevi spontaneously subsided in 248 (99.2％) of the 250 patients,and 122 (48.8％) of the patients were complicated by vitiligo.Univariate logistic regression analysis showed that age,number of lesions,complication by vitiligo and therapeutic methods were factors influencing the treatment outcome of halo nevus.Multivariate logistic regression analysis revealed that age ≤ 19 years or ≥ 40 years,disease duration ＞ 1 year,solitary lesions,absence of vitiligo and nevus removal were independent factors for effective treatment of halo nevus.Conclusions Most of halo nevi cannot subside spontaneously.CO2 laser or surgical excision combined with externally applied agents is effective for the treatment of halo nevus.For halo nevus patients without vitiligo,it's preferred to remove the halo nevi.For halo nevus patients with vitiligo,nevi should be removed in the stable stage of vitiligo.Relapse often occurs in patients with multiple halo nevi or large-area vitiligo,so close follow-up is needed.

A Case of Halo Phenomenon Induced by Molluscum Contagiosum / 대한피부과학회지

Halo nevi (HN), also known as Sutton's nevi or leukoderma acquisitum centrifugum, are nevomelanocytic nevi surrounded by a rim of depigmentation. A 9-year-old female presented with an asymptomatic solitary flesh-colored 0.75-cm-sized papule surrounded by depigmentation on the right cheek 1 month ago. The excisional biopsy demonstrated molluscum contagiosum and decreased basal layer pigmentation on Fontana-Masson stain. The halo phenomenon is often associated with an acquired nevus cell nevus, but has also been associated with a congenital nevus cell nevus, non-neuroectodermal lesions such as angiomas, seborrheic keratoses, lichen planus, sarcoid, psoriasis, involuting flat warts, and histiocytoma. Our patient had an unusual association of molluscum contagiosum with the halo phenomenon. We suppose that the halo phenomenon in this patient might have been provoked by the molluscum contagiosum virus. A halo nevus-like appearance suggests the possibility of disease other than nevus. In such cases, skin biopsy is required for confirmation.

Halo Nevi and Vitiligo in Turner's Syndrome / 대한피부과학회지

Turner's syndrome (TS) is a genetic disorder caused by numeric and/or structural abnormalities of the X chromosome. It is characterized by a short stature, gonadal dysgenesis, and frequently by webbed neck, cubitus valgus, lymphedema, broad chest with wide spaced nipples, micrognathia, and brachimetacarpalia. Several cutaneous manifestations are associated with TS, including melanocytic nevi, hypertrophic scarring, and vitiligo. Rarely reported findings include hemangiomas, angiokeratomas, and halo nevi. We present a case of halo nevi and vitiligo in a 13-year-old girl with TS. To the best of our knowledge, halo nevi and vitiligo in TS has not been reported in the Korean literature.

Poliosis of Eyelashes as an Unusual Sign of a Halo Nevus

A 39-year-old man with poliosis of his lower eyelid lashes visited our clinic. He reported that his symptoms began with a few central lashes and then spread along the adjacent lashes during the ensuing 2 weeks. A pigmented nevus, approximately 4 mm in diameter, was identified just above the white lashes without surrounding skin depigmentation. No specific findings were identified with regard to the patient's general health or serologic and radiologic testing. Excisional biopsy of the pigmented nevus was performed. On histopathologic examination, infiltration of the dermis by numerous lymphocytes and melanophages was observed. The poliosis was ultimately diagnosed as a presenting sign of the halo phenomenon in the regressive stage of a melanocytic nevus.

Development of Halo Nevus Around Nevus Spilus as a Central Nevus, and the Concurrent Vitiligo

Halo nevus is a benign melanocytic nevus that is surrounded by a hypopigmented zone. The most frequent association with halo nevus is vitiligo, and this also appears in nearby regions, as well as at other remote sites. Although the mechanism for developing the depigmentation around nevus spilus is uncertain an immunologic process may be responsible for the finding of inflammatory infiltrates of the upper dermis in the depigmented lesions. We report here on a 13-year-old boy who showed a depigmented zone around a nevus spilus on the right side of his neck with simultaneous vitiligo lesions on the face.

Poliosis Circumscripta Associated with Halo Nevus of the Scalp / 대한피부과학회지

Poliosis circumscripta describes a localized patch of white hair due to deficiency of melanin in the hair follicles. It is a feature of various conditions such as piebaldism, Vogt-Koyanagi-Harada syndrome, tuberous sclerosis, vitiligo, recent herpes zoster infection, or overlying a scalp neurofibroma. We report a rare case of poliosis circumscripta associated with halo nevus of the scalp. A 24-year-old woman presented with a 10 year history of an asymptomatic, pinkish nodule on the scalp which had overlying poliosis. On histopathological examination, dermal nevus cells were observed and the hair follicles of the depigmented patch were found to be devoid of pigment.