ABSTRACT
Objective To observe the effect of evidence-based nursing combined with targeted nursing on rehabilitation of children with hand, foot and mouth disease complicated with encephalitis. Methods One hundred and eight children with hand, foot and mouth disease and encephalitis who were treated in Xiaoyi People's Hospital from February 2015 to August 2017 were selected. The time node was May 2016, 58 children who were treated from February 2015 to April 2016 were selected as a single nursing group, and 50 children who were treated from May 2016 to August 2017 as a combined nursing group. The single nursing group adopted targeted nursing; while the combined nursing group adopted evidence-based nursing on the basis of the single nursing group. Flow cytometry was used to detect the level of white blood cell count (WBC) in cerebrospinal fluid (CSF); enzyme-linked immunosorbent assay (ELISA) was used to determine the content of CSF protein; high performance liquid chromatography (HPLC) was used to detect the content of CSF glucose (Glu); and the rehabilitation effect, complication rate, family satisfaction and hospitalization time of the two groups were observed. Results The levels of WBC, protein and Glu in CSF of the two groups were lower than those before treatment, and the above indexes in the combined nursing group were significantly lower than those in the single nursing group [WBC (×106/L): 16.98±5.76 vs. 32.53±10.74, protein content (g/L): 0.29±0.06 vs. 1.02±0.14, Glu (mmol/L): 3.26±0.28 vs. 4.69±0.51, all P < 0.05]. Compared with the single nursing group, the hospitalization time of the children in the combined nursing group was significantly shortened (days: 8.2±2.2 vs. 14.6±3.1), the total effective rate of rehabilitation and family satisfaction were significantly increased [total effective rate of rehabilitation:94.00% (47/50) vs. 75.86% (44/58), family satisfaction: 98.00% (49/50) vs. 91.38% (53/58), P < 0.05], and the incidence of complications was significantly reduced [6.00% (3/50) vs. 27.59% (10/58), P < 0.05]. Conclusion Evidence-based nursing combined with targeted nursing can improve the treatment efficiency of children with severe hand, foot and mouth combined with encephalitis, reduce the incidence of complications, speed up recovery and enhance the confidence of patients' families.