ABSTRACT
Background:Head and neck lesions are commonly encountered in patients across all age groups. This region encompass a multitude of congenital, inflammatory or neoplastic lesions.To study different Head and neck lesions, find out frequency of benign and malignant head and neck lesions, histopathological appearance, compare and correlate the various histopathological Head and Neck lesions in relations to age, gender, and site of distribution at P. D. U. Medical College & Hospital, Rajkot, Gujarat, India. Material And Methods:Received specimens were fixed in 10% formalin overnight, processed, blocks were made and sectioning was done and stained with Harris Haematoxylin and Eosin stain in histopathology laboratory. Result:Total 1531 cases were studied during the periodof 1stAugust 2019 to 31stJuly 2021. Out of 1531 cases 991 were males and 550 females respectively. The most affected age group was 41-60 years. Most common anatomical site affected was Nose and Paranasal sinuses. This study include Infectious diseases as a leading cause of Head and Neck lesions because it includes period of Covid Pandemic with most common infection was Mucormyosis. Conclusion:We concluded that site specific data is helpful in evaluating common and rare lesions of head and neck and it also give idea about which site affects more frequently. We also concluded that period during which study is conducted is having huge impact on result.
ABSTRACT
Introduction: Diagnostic cytology is the science of interpretation of cells that are exfoliated from the epithelial surfaces or removed from various tissues. The aim of this study was to assess the utility of cell block in increasing the cytodiagnosis of fine needle aspirates of head and neck lesions and to apply immunohistochemical markers on cell blocks. Material and methods: Total sample of 50 patients of head and neck lesions were received in the Department of Pathology, after approval from the Institutional Ethics Committee. Informed consent of the patient was taken. Relevant history of the patient was taken as per the written proforma. Patients of all age group presenting with head and neck lesions underwent FNAC and histopathological examination was included in the study. Results: Thus FNAC served better than cell block in determining the cellularity (kappa κ – statistic = -0.04, P 0.0002) while on morphological preservation grounds,superior nuclear and cytoplasmic characteristics were observed in cell block in comparision to FNAC (κ – statistic= -0.08).Overall Sensitivity and positive predictive value of cell block method with imunohistochemistry (96% and 100% respectively) proved to be better as compared to FNAC alone (88.8% and 95.65%). Conclusion: The diagnostic value of a Cell Block technique with immunohistochemistry is found to be superior to FNAC smears for the diagnosis of benign and malignat lesions of head and neck region. Taking into consideration the advantages of Cell Block method an excellent complementary tool for improving cytodiagnosis, we can recommend that cell blocks preprations should be routine practice so as to augment the information that is obtained solely from FNAC smear cytology.
ABSTRACT
Fine needle aspiration cytology (FNAC) is of particular relevance in head and neck lesions because of easy assessibility, excellent patient compliance, miminally invasive nature of procedure and helping to avoid surgery in non-neoplastic lesions, inflammatory conditions and also some tumors. The study was conducted on 160 patients presenting with non-thyroidal head and neck swellings. Swellings arising from lymphnodes formed largest group 110 (68.75%) cases, salivary gland origin leisions comprised of 15(9.3%) cases and miscellaneous lesions 35 (21.8%) patients. Aspiration was satisfactory in 153 (95.63%) and unsatisfactory in 7 (4.40%) patients. The cytodiagnostic yield was 147 (91.87%) cases in the study. In 46 patients surgical intervention and histopathological examination (HPE) of the specimen was undertaken. The sensitivity of FNAC compared with HPE where available in diagnosing lymphnode lesions was 83.33%, salivary gland lesions was 100% and miscellaneous swellings was 95.83%. The overall sensitivity in the study in diagnosing non-thyroidal head and neck lesion was 93.47%. No major complication was recorded.
ABSTRACT
BACKGROUND: Members of the genus Malassezia, lipophilic yeasts, are considered to be one of the exacerbating factors in atopic dermatitis. When the response of anti-inflammatory treatment of atopic dermatitis to adults was poor, antifungal treatment had a good response to atopic dermatitis. We compared Malassezia species detected in head and neck lesions of atopic dermatitis between children and adults. OBJECTIVE: To compare Malassezia species between children and adults in head and neck lesions of atopic dermatitis and to reveal the correlation levels of P. ovale specific IgE and clinical severity among these groups. METHODS: Malassezia species were incubated in Leeming and Notman media from skin lesions of 28 patients with head and neck lesions of atopic dermatitis (13 children, 15 adults). And ITS1 amplification and sequencing method was done for detection of Malassezia species. We also assayed P. ovale specific IgE and clinical severity grade of the patients. RESULTS: M. globosa was the predominant species in the children group. And M. furfur was the predominant species in the adults group respectively. The levels of P. ovale specific IgE increased more in the adults group than the children group. Clinical severity grade also more increased in the adults group. There was statistically significant correlation between P. ovale specific IgE and clinical severity grade (p<0.001). Conclusion: Malassezia species are aggravating factors in head and neck lesions of atopic dermatitis particularly in adults. We must keep in mind Malassezia species infection when resistance to antiinflammatory therapy in atopic dermatitis of adults.